Anabolics
Search More Than 6,000,000 Posts
Results 1 to 8 of 8
  1. #1
    sp9's Avatar
    sp9
    sp9 is offline MMA Competition Sentinel
    Join Date
    Feb 2002
    Location
    Land of milk and honey.
    Posts
    3,585

    CNN article - Pill to replace exercise possible

    http://www.cnn.com/2002/HEALTH/diet.....ap/index.html

    Researchers: Pill may someday replace exercise

    April 11, 2002 Posted: 3:41 AM EDT (0741 GMT)

    WASHINGTON (AP) -- Pop a pill, get in shape.

    That ultimate fantasy of the couch potato may become a reality some day, according to researchers who have found the chemical pathways that muscle cells use to build strength and endurance.

    With this basic knowledge in hand, it now may be possible to develop a pill that pumps up muscle cells without all that exercise, said Dr. R. Sanders Williams, dean of the Duke University of School of Medicine and senior author of a study appearing Friday in the journal Science.

    Does this mean sedentary people could build muscle by taking pills?

    "That may be one of the possibilities," said Williams, but the main target of the research is to promote the health of people with heart disease or other conditions that keep them from doing enough exercise.

    "This could lead to drugs that will let people get the health benefits of regular exercise, even if they cannot exercise," said Williams. This could help patients with heart or lung disease, or lower the risk of Type II diabetes, for instance.

    "It is possible it could become a drug of abuse because it would enhance the performance of athletes," he said.

    In the study, Williams and colleagues at the University of Texas Southwestern Medical Center in Dallas created a group of mice with genes that made a surplus of a protein called calmodulin-dependent protein kinase, or CaMK. When this protein is activated, it and another protein, calcineurin, trigger the physical changes that muscle cells undergo after intense exercise.

    Williams said mice with a high level of CaMK developed more mitochondria in muscle cells and saw an increase of a type of cell called the "slow twitch" muscle. These are muscle cells that power sustained activity, such as that required by marathon runners.

    For "fast twitch" muscles, which provide a burst of strength for a short period of time, there was an increase in the number of mitochondria.

    The researchers found that mice with high levels of CaMK developed the same healthy muscle cells as mice that did exercise.

    "The effect increases more of the slow twitch muscles, but it also increases the number of mitochondia in the fast twitch muscle cells," he said. "That is very similar to what happens in very intense training."

    Mitochondria are structures inside a cell that provide energy by metabolizing oxygen and nutrition. Cells with many mitochondria can produce more work over a longer time. Physical training increases the number of mitochondria in muscle cells.

    Williams said a drug that would trigger the CaMK muscle signaling pathway has not been found, but now that there is a specific target it should made the development easier.

    "Pharmaceutical companies are very good at that," he said.

    Dr. Keshav Singh of Johns Hopkins University School of Medicine said the paper by Williams and his group is an "important advancement in understanding the mechanism that creates more mitochondria in muscles."

    "Since levels of mitochondrial proteins decrease with normal aging, this study may also help develop therapies to increase the physical endurance in the aged," said Singh, who is a mitochondria researcher at Hopkins.

  2. #2
    arthurb999's Avatar
    arthurb999 is offline Anabolic Member
    Join Date
    Aug 2001
    Location
    USA
    Posts
    2,715
    When that pill comes out, I will include it in my stack

  3. #3
    NightOp is offline Member
    Join Date
    Jan 2002
    Location
    USA
    Posts
    896
    saw the same article on Fox News website (i like them the best)... very interesting.

  4. #4
    RON's Avatar
    RON
    RON is offline Anabolic Member
    Join Date
    Aug 2001
    Location
    So Cal
    Posts
    5,461
    That will ad an hour of time for me to be on AR ever day

  5. #5
    Commander_Bash's Avatar
    Commander_Bash is offline Junior Member
    Join Date
    Mar 2002
    Location
    Brooklyn N.Y
    Posts
    130
    Imagine having a pill like that you think if they were to make something like that people would get super huge?

    Peace
    Bash

  6. #6
    Zoolander's Avatar
    Zoolander is offline Junior Member
    Join Date
    Jan 2002
    Posts
    118
    I just hope that they make the pill available in my lifetime

  7. #7
    sp9's Avatar
    sp9
    sp9 is offline MMA Competition Sentinel
    Join Date
    Feb 2002
    Location
    Land of milk and honey.
    Posts
    3,585
    I think we are all going to see some freaky things in the coming years. Just heard a story on the news last night about deaf people who want to genetically alter their children to make it a 100% chance that their babies are deaf (this is possible now).

    In our life times you will be able to genetically engineer your children, the enitre gene sequence for humans is mapped, and it's only a matter of time before you will be able to get "gene therapy" to improve what you want. I don't necessarily think it is a good thing to mess around with the human race like that.

    But then again I believe there was a creator, and we didn't evolve from some gases floating around at the "big bang". Many will disagree......

  8. #8
    NightOp is offline Member
    Join Date
    Jan 2002
    Location
    USA
    Posts
    896
    Originally posted by scottp999
    ..........In our life times you will be able to genetically engineer your children, the enitre gene sequence for humans is mapped, and it's only a matter of time before you will be able to get "gene therapy" to improve what you want. I don't necessarily think it is a good thing to mess around with the human race like that.

    But then again I believe there was a creator, and we didn't evolve from some gases floating around at the "big bang". Many will disagree......
    i'm with ya there bro and certainly do not disagree.

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •