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  1. #1
    AZGOLDSMEMBER86's Avatar
    AZGOLDSMEMBER86 is offline Senior Member
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    ok my tamox prescription ..

    have 3 10mg tbs left . my script wontbe in till Friday .. will i be ok?

  2. #2
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    AZGOLDSMEMBER86 is offline Senior Member
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    bump

  3. #3
    DanB is offline Banned
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    is it pct, trt, on cycle?

    what dose you currently on?

  4. #4
    AZGOLDSMEMBER86's Avatar
    AZGOLDSMEMBER86 is offline Senior Member
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    for gyno reversal from doc.

  5. #5
    Atomini's Avatar
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    You'll be fine. The half life of Nolvadex is actually 7-14 days, NOT 24 HOURS as so many would have you believe. If you've been taking it for a while, you're good.

  6. #6
    dec11's Avatar
    dec11 is offline 'everything louder than everything else'
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    Abstract
    We have shown previously that a reduction from the conventional dose of tamoxifen is associated with a comparable modulation of circulating biomarkers, including insulin -like growth factor-I and cholesterol. In the present study, we have correlated serum tamoxifen elimination with biomarker recovery in healthy subjects completing a 5-year intervention period. Tamoxifen, N-desmethyltamoxifen, and biomarker levels were measured at 0 (baseline), 2, 4, and 6 weeks after completion of treatment in 23 healthy postmenopausal women allocated to tamoxifen 20 mg/day and in 6 women allocated to placebo. Mean (+/-SD) serum tamoxifen and N-desmethyltamoxifen concentrations were, respectively, 141 +/- 50 and 226 +/- 77 ng/ml at baseline, 36 +/- 19 and 99 +/- 46 at 2 weeks, 20 +/- 15 and 61 +/- 37 at 4 weeks, and 12 +/- 9 and 36 +/- 26 at 6 weeks. Serum tamoxifen and N-desmethyltamoxifen half-lives were 9 and 13 days, respectively. Body mass index was associated positively with drug's serum half-life. Compared with baseline values, the percentage increase in total cholesterol, low-density lipoprotein cholesterol, and insulin-like growth factor-I 4 weeks after treatment completion was 5, 9, and 14%, respectively. No change during the 6-week period was observed in the placebo arm. Our findings indicate that the biomarker recovery is slower than serum tamoxifen elimination, suggesting that low tamoxifen concentrations may still exert a biological effect. In addition, the prolonged half-life of tamoxifen and metabolite provides the rationale for a weekly administration of the drug in a preventive context. However, the clinical implications of our findings remain to be defined.

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