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Originally posted by tenn0titan
Wanted to post this to get some discussion going on this new drug being used in BB. Have you taken it? Do you think you might? Lets hear your side of its use. As for me I do plan on taking it. Got to give it a try.
Peace
TT
Read and tell us want you think:
Lutalyse is a veterinary drug that's coming into vogue with serious hardcore bodybuilders who'll stop at nothing to gain an "advantage" (even if it's not a real advantage). utalyse is made by Upjohn and is a prostaglandin (PGF2Aa).
PGF2a possibly mediates the endogenous insulin levels and is also a de facto thermogenic, as body temperature is increased after the administration of exogenous PGF2a. Unlike other fat burners, which only decrease the size of fat cells, PGF2a actually destroys them. Fat cells die when exposed to PGF2a.
Side effects associated with PGF2a use are an elevation in body temperature, vomiting, labored breathing and severe abdominal pain/cramping. As PGF2a vasoconstricts the blood vessels in the lungs, the user will feel a tightening in the chest. If you're an asthmatic, use of PGFa could very well put you into full respiratory arrest followed by death. Because PGF2a increases insulinogenic effects, hypoglycemia is a potential side effect.
PGF2a has a very short half-life in the body (only minutes) and most of it is metabolized in the lungs, thus making frequent injections necessary. PGF2a will almost always cause a very strong contraction of the intestine and bladder, emptying the stomach and intestines of all its contents. That's a nice way of saying you'll have explosive diarrhea.
Rumor has it that PGF2a will make training near impossible because of the pump that is created from this drug alone. One of the logistical drawbacks of PGF2a is the difficulty of administration. As it has such a short half-life, injections will be needed quite frequently. Lutalyse comes in a 5 ml (5 mg/ml) multi-dose vial. A single aspirin can render the effects of Lutalyse nonexistent, so most people who use this drug avoid aspirin and aspirin analogs.
Legit use of Lutalyse is by cattle farmers and ranchers. Farmers and ranchers will use this drug to induce abortions in barnyard animals. One-hundred percent of the idiots, uh, I mean, users, I spoke with told me that Lutalyse made them feel terrible. In short, this stuff could kill you, a lot faster that steroids ever could. I wouldn't suggest anyone try this stuff.
Is PGF2A for me?
Is PGF2A for everyone? Clearly not! Will it work? Yes! In this information, I will try to cover as much as possible about this drug. What I have put together here is based much upon personal experiences…. I feel no report can accurately prepare you for everything…. PGF2A is no exception!
PGF2A and Anabolism
Many studies have demonstrated an anabolic effect of PGF2A in skeletal muscles of both humans and animals. Paradoxically, PGF2A usage is still reserved to a bodybuilding elite and no one is willing to divulge the precious secret edge. One of the most remarkable effects of PGF2A is that it mediates the major part of the anabolic effects of insulin. By using PGF2A, you can use far less insulin and get a far stronger muscle building effect.
Is PGF2A safe?
The answer is clearly no, but neither is the use of steroids, insulin, clenbuterol, etc. By the way, PGF2A is invisible at any drug test. What kind of side effects to expect? The first ones -- if we except the elevation of temperature -- are that it will empty your guts of whatever they contain. So make sure you have unrestricted use of a bathroom. This is going to last around 20 minutes. What you do not want is to inject PGF2A into a vein! Learn to do the aspiration test. PGF2A is to be injected intramuscularly with an insulin needle if you are lean enough. This is going to hurt like hell and for a very long time (up to an hour) if you inject into a vein. You also may feel as if you had some kind of cold in your throat. It is due to the vasoconstriction effect PGF2A has in your lungs. Vomiting is a reported side effect but I have never heard of it in men.
PGF2A is not to be confused with steroids
You've probably realized by now that PGF2A produces growth in a radically different way from steroids -- although I do not exclude that part of the anabolic actions of androgens are mediated by a local release of PGF2A. The way PGF2A should be used is therefore radically different from that of androgens. Steroid use is rather comfortable. You inject or swallow them occasionally and wait for the growth to occur. This is not the case with PGF2A. Their main drawback is precisely their difficulty of administration. Steroids once injected survive several days in your body. PGF2A will last only several minutes though their stimulatory actions on anabolism will be far longer lasting (hours). It means that frequent injections are compulsory. Ideally, this would be five times per day, 30 minutes after meals.
You will also notice that once you have injected PGF2A, the muscle, which received it, gets sore almost immediately. If the muscle was already sore from training, that painful sensation may become very intense. You definitely do not want to repeat injections at the very same location, hence the necessity for rotation. Similarly, you will notice that you cannot inject in a muscle and then train this muscle. PGF2A is algesic (a pain mediator). Therefore, the timing of injections is key. You should wait for at least 2 to 3 days after you have trained a muscle to inject it. Then you will have to wait for 24 hours before training this muscle. If your muscle is already sore, I advise against using it as a site of injection as long as it hurts.
You will also learn that it is more comfortable to hit the outer part of the muscle than the inner part. For example, it is less painful to hit the outer head of the triceps than the inner head that touches your lats. Some bodyparts such as the biceps, the back, etc. are especially sensitive to the pain sensation PGF2A will induce.
PGF2A and Weak Bodyparts
The cardinal rule of PGF2A is to inject as far away as possible from the Intestine. You see, PGF2A induces a very strong contraction of the Intestine and the bladder (both smooth muscles). The major candidate as a site of injection was the front shoulder. But by repeating injections in the shoulders, bodybuilders soon ended up with grossly overdeveloped
Front delt's. They looked like walking monkeys. The rest of their body was growing too, but not as fast as the muscles closest to the sites of injections.
What this means is that if you want to develop a weak muscle, just inject PGF2A locally and watch! The muscle grows. We are talking about a real muscle growth and not an artificial swelling like Synthol or Esiclene would induce. Calves are a muscle of choice. In fact, even if your calves failed To grow no matter how much training you administered, PGF2A will
solve your problem. After a single cycle of PGF2A, unresponsive calves start to respond, even if they never did before!
The localized growth induced by PGF2A may appear magical, but there is a simple explanation. The life cycle of the injected PGF2A is terribly short (minutes). Most of it will .Be destroyed in your lungs. If you hit your right calf for example, this muscle will be exposed to a maximal concentration of PGF2A. As the prostaglandin rapidly leaks out of the calf and passes into the blood, it will quickly reach the lungs where most of it will be destroyed. What is left of the PGF2A will be dispatched evenly though you're whole body. It means that the other muscles will be exposed to far less of the anabolic effects of PGF2A. So unless you want to make a weak point grow, you should rotate the sites of injections frequently which is not a problem.
The way I would, or rather AM gonna run it is to start with .25ml (basically 1.25mg) injected twice daily, 5 days a week post workout. We'll see how tha works out as far as sides go. From there, id increase FREQUENCY before increasing DOSE. So id work up to taking this stuff 4-5 times a day @ 1.25mg per dose. Then and only then would I dare try to increase the dosage of this stuff.
From what I hear doing any more than 1ml (5mg) at a time is going to give you some serious problems (****s, vomiting, etc).
PGF2a would go well in a stack with Slin or IGF-1.
PGF2a + IGF-1: The ultimate cocktail for localized muscle growth?!
Say good by to lagging body parts forever. It is a special time to be a bodybuilder. With the advent of PGF2a as a localized anabolic agent along with the newly available rhIGF-1 which has also been shown to build muscle where you want it, the future for genetically challenged bodybuilders looks bright indeed. A brief refresher course on locally injected IGF-1. Non-exercised muscle, when injection with 0.9 - 1.9 micrograms/kg/day of rhIGF-1 was shown to mimic the effects of physically loading the muscle. Much the same effect PGF2a but by different mechanisms. With local IGF-1 injections there is an increase in protein content, cross sectional area and DNA content. The increase in muscle DNA is presumed to be a result of increased proliferation and differentiation of satellite cells which donate their nuclei upon fusion with damaged or hypertrophying muscle cells. Take note that the quantities of IGF-1 needed are extremely small, much smaller than studies that have shown relatively poor results from administering IGF-1 systemically which range from 1.0 to 6.9 milligrams/kg/day.
Now add PGF2a to the mix and whalla! You can virtually mimic the mechanical stimulus of training without even picking up a weight. You have PGF2a to accelerate short term protein synthesis by activating ribosomes and/or eIFs and thereby translation, as well as IGF-1 to activate satellite cells to bind and donate additional nuclei to boost the amount of mRNA to be used by the ribosomes. Because the mechanism of action is different, the two compounds should compliment each other delivering results beyond what either one alone could produce.
Say what?
PGF2a usually comes in a 5mg/ml concentration.
Its best to start off with a dose of 2.5mg (or less!) done twice a day, 5 days a week. Thats 1/2cc at a time, or 50IUs on a slin pin
From there Id suggest you begin with increasing frequency rather than dose, heres why:
1) PGF2a has a terribly short half life. Youd be better off shooting several small doses than shooting few, but big doses.
2) PGF2a'a sides are totally dose dependent. The higher the dose, the more of the sides your going to experiance. Again, PGF2as half life is very short, so the sides you experiance will subside about an hour or two after you shoot. Basically what Im saying is more frequent use is not very likely to cause an increase in the severity of sides, however an increased dose will.
By the time you reach 4-5 doses a day, then you may consider tinkering with doses. Most people achive great results with just shooting 2.5mg to 3.75mg at a time. At a full 5mg a dose the sides will likely be severe and not longer worth the effort.
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