Originally Posted by Pheedno
If the b6 needs to be raised to 300mg then I'll do so, but I've ran tren above test almost everytime without problems
As for progesterone, its not really a concern once steady state is reached
The PR has two isoforms; the A and B. PR-B mediates stimulatory effects of progestins; the PR-A which is bound with progestins or anti-progestins inhibits PR-B, and PR-A is dominant. The response to progesterone is determined by the relative expression of the two isoforms.
Now, their is a direct relationship between the PR isoforms and steroid concentrations. The direct relationship suggests high progesterone concentrations, but this will induce the expression of PR-A, which represses transcription of PR-B, which in turn supresses PR function and progestin effect
With initial administration, I could see an expression of PR-B but a rapid rise in PR-A will ultimately supress the function of the PR. I would suggest that you'd need a high ratio of the two before concerns, and this is a bit more of a possiblity with the begining of administration.