09-05-2004, 11:56 AM #1Junior Member
- Join Date
- Jul 2004
this goes out to those who know a thing about chemistry
Ive been reading alot of posts about steriods affecting serotonin and dopmine levels, some steriods raise them and some steriods lower them. I no that testosterone raises dopamine.
But my question is who can tell me which drugs raise them and which drugs lower them, could somone give me a list, it would be greatttllyyy appreaciated.
09-05-2004, 02:24 PM #2Junior Member
- Join Date
- Jul 2004
1. The effects of treating groups of rats with four different anabolic androgenic steroids (AAS) (testosterone , nandrolone , methandrostenolone , and oxymetholone) on 5-hydroxytryptamine (5-HT) and dopamine (DA) neurones in different brain regions were examined. The AAS was injected six times with 1 week's interval and the rats were sacrificed 2 days after the final injection. 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. The effect on DA and 5-HT synthesis rate was analysed as the accumulation of 3,4-dihydroxyphenyl-alanine (DOPA) and 5-hydroxytryptophan (5-HTP), respectively, after inhibition of the amino acid decarboxylase with NSD-1015 (3-hydroxy-benzylhydrazine dihydrochloride). Additionally, the monoamine oxidase (MAO) activity was analysed in the hypothalamus. 2. The DOPAC + HVA/DA ratio was increased in the striatum in all treatment groups. However, the synthesis rate of DA was significantly increased only in the methandrostenolone treated group. 3. The 5-HIAA/5-HT ratio was increased in all treatment groups in the hippocampus, in the frontal cortex in the methandrostenolone-treated animals and in the hypothalamus in the testosterone- and oxymetholone-treated rats, while the 5-HT synthesis rate was not affected by the AAS-treatments. 4. The MAO-A activity was increased in the oxymetholone-treated rats while the other treatment groups were unaffected. The MAO-B activity was not changed. 5. The results indicate that relatively high doses of AAS increase dopaminergic and 5-hydroxytryptaminergic metabolism in male rat brain, probably due to enhanced turnover in these monaminergic systems
I FOUND THIS, BUT I DONT UNDERSTAND IT LOL
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