Gyno Whiplash?

I finished my last cycle at the end of June which consisted of Prop 100mg's ED and Tren 75mg's ED. I ran PCT which included clomid, nolva, and B-6 as well as 10mg's of nolva throughout the cycle. About 2 weeks ago I noticed my left nipple was extreamly sensitive so I jumped back on some nolva and L-dex along with B-6, but it is still sensitive :frown: I'm wondering if it could be prolactin induced from the Tren :scratch: This is the first time after about 8 cycles that something like this has occured, but keep in mind I have ran Tren before this cycle. Anyone have any suggestions/input? :yellowcon

What dose of B6 are/or were you running?

run the nolva at 80mg/ed till symptons subside. also what wa your dose of b-6? if u arent on it anymore run it at 600mg/ed with the nolva till they leave

Quote:

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Originally Posted by bluestrm

What dose of B6 are/or were you running?

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during PCT 200mg's ED now 400mg's ED

Yeah, bump it up to 2 doses per day of 300mg.

Preventing and Alleviating Progesterone Induced Gyno

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Very good read.
Originally posted on AR by Pheedno.


The following are excerpted from OB/GYN class notes:
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Suppression of Lactation:

When the mother chooses not to breast feed or the baby is lost, suppression of lactation may be required. Initially the breasts get engorged, however in the absence of suckling further milk production stops on its own. Firm support to the breasts is helpful in reducing the discomfort. Manual expression is not very helpful as it promotes further milk secretion. Estrogens in high doses can suppress lactation, however there are side effects and the risk of venous thrombosis, hence these are not recommended. Bromocryptine, a dopamine agonist, given 2.5 mg twice a day for 14 days can suppress lactation by producing a fall in prolactin levels. This therapy is expensive, has side effects and there may be rebound lactation once the drug is stopped. FDA no longer approves it. Pyridoxine – Vitamin B6, given 200 mg three times a day for 5-7 days is quite effective in suppressing lactation and the drug has no side effects.
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Got Wood? note : adding Bromo to your cycle only adds to the potential anabolic cascade, and potentially negative drug interactions. In medicine B6 is supposed to be as effective as Bromo. Plus vitamin B6 has few side effects.
Here are a few of many studies supporting the use of Vitamin B6 in reducing prolactin:
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J Clin Endocrinol Metab 1976 Mar;42(3):603-6


Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway.

Delitala G, Masala A, Alagna S, Devilla L.

A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine.

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N Engl J Med 1982 Aug 12;307(7):444-5

Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise.

Moretti C, Fabbri A, Gnessi L, Bonifacio V, Fraioli F, Isidori A.

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Boll Soc Ital Biol Sper 1984 Feb 28;60(2):273-8

[Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects]

[Article in Italian]

Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C.

The influence of vitamin B6 in a dosage of 300 mg X 2 in 24 hrs, on circadian rhythm of plasmatic ACTH, cortisol, prolactin and somatotropin have been studied in 10 normal women. After vitamin B6 24 hrs pattern of ACTH and cortisol is unchanged; prolactin levels are slightly lower, in a statistically unsignificant proportion the night peak of growth hormone is higher in a statistically significant proportion (p. 0.05). The effect of vitamin B6 is likely to me mediated by dopaminergic receptors at hypothalamic level as previous studies by other Authors appear to prove

sounds good, anyone else?

is B6 a must run if you're only on test and dbol (first 4 weeks)?

nope. b-6 is for prolactin and progesterone gyno. nolva is though IMO

I needed to run 1000mg b6 for it to work