Quote:
Originally posted by Mr. Fina
Transfer of hydrogen, in the form of either a proton or a hydride ion, from one atom to another in the same molecule, is the most common chemical reaction in biology, and is also perhaps the simplest. Yet it is not always an easy reaction to carry out rapidly. When the donor and acceptor atoms are unreactive carbons or oxygens, the uncatalyzed reactions are usually very slow, because the -C-H and -O-H groups are not very acidic (both typically have pKa values near 20) You could end up changing the conformation of the molecule and what it does chemically in your body.
replace the -O-H group with a fluoride, as in halotestin. this reaction happens very fast. yes, it drastically changes the physiological response your body gets from halo compared to dhea, but might point was that ionizing steroids can make them water soluble to a certaind degree.