Nolvadex will help with progestin induced/prolactin gyno... (GOOD READ)

[D00fy]

I was doing searchs on "Deca " and i found a really old thread and i Bumped it for more studies,

Mister X from EF...... Has posted some good info



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Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin /insulin-like growth factor-I, serum, and estrogen.
Endocrinology 1990 Feb;126(2):891-8 (ISSN: 0013-7227)
Katzenellenbogen BS; Norman MJ [Find other articles with these Authors]
Department of Physiology and Biophysics, University of Illinois, Urbana 61801.
: Endocrinology 1990 Jan; 126(6):3217
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Hormones as cancer growth factors.
Lancet 1984 Oct 13;2(8407):843-4 (ISSN: 0140-6736)
Israel L; Band P [Find other articles with these Authors]
It is postulated that some hormones may regulate proliferation of cancer cells in the same way as growth factors produced by cellular oncogenes. The gene coding for the hormone's specific receptor would also act as a cellular oncogene. Normal adult breast cells show few if any oestrogen receptors. In the model put forward the oestrogen receptors in breast cancer cells should not be regarded as a marker of differentiation but as a survival advantage for the tumour when oestrogens are present. Prolactin and somatomedin may also behave as growth factors. In relation to the antitumour effects of hormone antagonists such as tamoxifen , it is postulated that cancer cells are immortalised and prevented from full differentiation by the presence of growth factors and their receptors. If receptor genes are re-expressed through the process of neoplastic transformation, their presence in cancers from unresponsive normal tissues should be regarded as a common event
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Insulin-like growth factor 1 receptors in human breast cancer and their relation to estradiol and progesterone receptors.
Cancer Res 1988 Nov 15;48(22):6429-33 (ISSN: 0008-5472)
Peyrat JP; Bonneterre J; Beuscart R; Djiane J; Demaille A [Find other articles with these Authors]
Centre Oscar Lambret, Lille, France.
Insulin-like growth factor 1 (IGF1) binding sites were characterized in breast cancer. We demonstrate the presence of one high affinity binding site. Chemical cross-linking of 125I-IGF1 to breast cancer membranes in reducing condition and sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed one band with an apparent molecular weight of 130,000. The specificity of the binding was studied. IGF2 was a good competitor whereas insulin competed with a potency lower than 1/100 that of IGF1. This IGF1 binding corresponded to the previously described type 1 IGF receptor (IGF1-R). IGF1-R was determined in 76 human breast cancer biopsies. Ninety-three % of the tumors were positive. The specific binding range was 0-16.4%; the geometric IGF1-R mean level was 3.9%. There was a relation (chi 2 test) between IGF1-R and progesterone receptor positivity rates (P = 0.002). The IGF1-R concentrations were correlated (Spearman test) with those of estradiol receptor (P = 0.0018) and progesterone receptor (P = 0.0011). A positive linear correlation existed between IGF1-R and estradiol receptor (P = 0.006) and between IGF1-R and progesterone receptor (P = 0.003). Our demonstration of the presence of IGF1-R in human breast cancer biopsies suggests that IGF1, acting either via the endocrine, paracrine, or autocrine pathways, could stimulate tumor growth.

If you appreciate the studies, thank 'Ivan Drago' from Anabolic Fitness, he looked up the research, not I.

Nolvadex lower IGF-1 level very effectively(by 24%)

[D00fy]

Winstrol will help with progestin receptor activity, but to what degree, that's the Q
Ellis AJ, Cawston TE, Mackie EJ.

Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK.

The anabolic steroid stanozolol stimulates the production of prostaglandin E2 (PGE2) and the matrix metalloproteinases collagenase and stromelysin in human skin fibroblasts but not in rheumatoid synovial fibroblasts. The basis for these differential responses was investigated at the levels of DNA synthesis and steroid receptor binding. Stanozolol inhibited fibroblast growth factor (FGF)-stimulated DNA synthesis in both the skin and synovial fibroblasts, showing that both cell types were capable of responding to the compound. Competitive binding assays indicated that stanozolol bound specifically to both the skin and synovial fibroblasts. Binding of stanozolol to both cell types could be partially displaced by progesterone, indicating that stanozolol binds to the progesterone receptor. Immunocytochemical studies confirmed the presence of progesterone receptors on skin and synovial fibroblasts. However, progesterone failed to elicit any response with respect to collagenase production in either cell type. Nortestosterone, dexamethasone and 17 beta-oestradiol had no effect on binding of stanozolol to either cell type. These results indicate that the inhibition of DNA synthesis by stanozolol is elicited through the progesterone receptor. The effects of stanozolol on collagenase and PGE2 production are mediated by a different receptor, present on skin but not synovial fibroblasts, and as yet unidentified.

[D00fy]

Here is the Link

http://boards.elitefitness.com/forum...34#post1292106


GIVE CREDIT TO THOSE WHO RESPONDED!!!!!!!!!!!!!!!!
thanx Mister X and the rest of yall

[iron4life79]

interesting..........i'd like to see some other bros take on this. dr evil, any thoughts?

peace bb79

[NightOp]

bump

[Dr.Evil]

href="http://www.steroid.com/Deca.php" target="_blank" class="gal">deca cycle because the steroid nandrolone

[Mike]

Flame me if you will but I firmly believe that the only two USED compounds to attack or prevent gyno from deca )


(btw Dr. E - I lost the post we were talking bout this in)

**BTW - for those wondering what ZK-89.299 is

Onapristone (ZK 89.299) is another progesterone antagonist. The only difference between these two progestrogen antagonists (ru-486 and zk-89.299), is the difference in antiglucocorticoid activities for the glucocorticoid receptor (GR). RU-486 provokes this action while Onapristone does not. RU-486 actually blocks corticoid action

[Dr.Evil]

yeah, i can't find it either.
deca

[D00fy]

- GAL -->

[PunkRawk]

i looked at those studies for like 2 secs and noted this....WE ARE NOT FUCKING WOMEN....i have never heard of a case of man coming down with breast cancer...these studies dealing with prgest and estrodial all have to do with women....and why would you want to lower igf-1??? igf cannot possibly have anything to do with gyno....otherwise we would all have it...

[vanjag]

PunkRawk...

There are cases of male breast cancer, so don't be so ultimative on this, since you are obviously not sufficiently informed. And the fact that you are not a fucking woman is just partially right, because both sexes have the same receptors, it just depends what kinds of hormones they are stimulated with.

......

[Dr.Evil]

Originally posted by D00fy

deca

[PunkRawk]

/>

Originally posted by vanjag
PunkRawk...

There are cases of male breast cancer, so don't be so ultimative on this, since you are obviously not sufficiently informed. And the fact that you are not a fucking woman is just partially right, because both sexes have the same receptors, it just depends what kinds of hormones they are stimulated with.

......

[D00fy]

thx good info for me

[vanjag]

PunkRawk...

What you are saying about IGF-1 is true, but note that it only helps tumor cell proliferation once there is a tumor, and does not act as a trigger mechanism to produce tumor cells. Of course, the study is done on women because to produce a sufficient statistical specimen of men with breast cancer, one would have to do a multicentrical clinical study, but the bottom line is that male breast cancer is histologically the same as female, it's only that it is much more common in females.

This being said, if I had to focus on one or two compounds which would pose danger for male bodybuilders to develop breast cancer, it wouldn't be IGF-1, but estrogen or progesterone, since this is the molecule that induces natural proliferation of lactiferous tubules that later have the ability to undergo anaplastic change and produce a tumor. These are what give you gyno, and then you have much better chances of growing a breast tumor, and in my opinion, this is when IGF-1 comes into play, once tumor is formed. My opinion is that IGF-1 shouldn't be looked upon with fear of developing a tumor.

V