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02-21-2005, 03:51 PM #1
Letrozole research proves it will reverse gyno
Hooker found this additional information:
J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):27-34. Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology.
Mandava U, Kirma N, Tekmal RR.
Department of Gynecology and Obstetrics, Emory University, 4217 Woodruff Memorial Building, 1639 Pierce Drive, Atlanta, GA 30322-4710, USA.
Our recent studies have shown thatoverexpression of aromatase results in increased tissue estrogenic activity and induction of hyperplastic and dysplastic lesions in female mammary glands and gynecomastia and testicular cancer in male aromatase transgenic mice. Both aromatase mRNA and protein are overexpressed in transgenic mammary glands and its expression is not limited to epithelial cells. However, it is more in epithelial than in stromal cells.Our results also indicate aromatase overexpression-induced changes in mammary glands can be abrogated [destroyed] with very low concentrations of the aromatase inhibitor, letrozole. Low concentration of letrozole had no effect on normal physiology as indicated by no significant change in the circulating levels of estradiol and follicle stimulating hormone as well as no change in estrogen responsive genes such as the progesterone receptor and lactoferrin in the uterine tissue. These observations indicate that the expression of aromatase in both epithelial and stromal cells can influence the complex interactions of biochemical pathways leading to mammary carcinogenesis and that the aromatase inhibitor, letrozole can be used as chemopreventive agents without affecting normal physiology.Last edited by RUI-Products; 02-21-2005 at 04:00 PM.
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02-21-2005, 03:53 PM #2
great post. i know there has been contraversy about this...
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02-21-2005, 03:59 PM #3
nice post
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02-21-2005, 04:08 PM #4
the test subjects were mice, here's one on humans (men)
Prevention and management of bicalutamide-induced gynecomastia and breast pain: randomized endocrinologic and clinical studies with tamoxifen and anastrozole.
Saltzstein D, Sieber P, Morris T, Gallo J.
1Urology San Antonio Research PA, Pasteur Medical Plaza, San Antonio, Texas, USA.
A randomized, double-blind, placebo-controlled multicenter trial involving 107 men receiving bicalutamide ('Casodex') 150 mg/day therapy following radical therapy for prostate cancer assessed tamoxifen ('Nolvadex ') 20 mg/day and anastrozole ('Arimidex ') 1 mg/day for the prophylaxis and treatment of gynecomastia/breast pain. Tamoxifen, but not anastrozole, significantly reduced the incidence of gynecomastia/breast pain when used prophylactically and therapeutically. Serum testosterone levels increased with tamoxifen relative to placebo but prostate-specific antigen levels declined in all treatment groups. Further studies are needed to define the optimum tamoxifen dose and to assess any impact on cancer control. The use of tamoxifen in this setting remains to be investigated.Prostate Cancer and Prostatic Diseases advance online publication, 1 February 2005; doi:10.1038/sj.pcan.4500782.
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02-21-2005, 04:09 PM #5Writer
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This is a study (the same one?) by those same people, in another Journal, which might be worded better to show that Letro actually stops/destroys the changes in breast tissue caused by aromatase.
Endocr Relat Cancer. 1999 Jun;6(2):307-14.
Aromatase overexpression and breast hyperplasia, an in vivo model--continued overexpression of aromatase is sufficient to maintain hyperplasia without circulating estrogens, and aromatase inhibitors abrogate these preneoplastic changes in mammary glands.
Tekmal RR, Kirma N, Gill K, Fowler K.
Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322-4710, USA.
To test directly the role of breast-tissue estrogen in initiation of breast cancer, we have developed the aromatase-transgenic mouse model and demonstrated for the first time that increased mammary estrogens resulting from the overexpression of aromatase in mammary glands lead to the induction of various preneoplastic and neoplastic changes that are similar to early breast cancer. Continued overexpression of aromatase that leads to increased breast-tissue estrogen contributes to a number of epigenetic changes in mammary tissue such as alteration in the regulation of genes involved in apoptosis, activation of genes involved in cell cycle and cell proliferation, and activation of a number of growth factors. Our current studies show aromatase overexpression is sufficient to induce and maintain early preneoplastic and neoplastic changes in female mice without circulating ovarian estrogen. Preneoplastic and neoplastic changes induced in mammary glands as a result of aromatase overexpression can be completely abrogated [destroyed] with the administration of the aromatase inhibitor, letrozole. Consistent with complete reduction in hyperplasia, we have also seen downregulation of estrogen receptor and a decrease in cell proliferation markers, suggesting aromatase-induced hyperplasia can be treated with aromatase inhibitors. Our studies demonstrate that aromatase overexpression alone, without circulating estrogen, is responsible for the induction of breast hyperplasia and these changes can be abrogated using aromatase inhibitors.[/QUOTE]
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02-21-2005, 04:16 PM #6Writer
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Originally Posted by dirtdawg
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02-21-2005, 04:20 PM #7Originally Posted by hooker
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02-21-2005, 04:25 PM #8Writer
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OH....well, anyhoo....
Yeah, I found those Letro Studies...I know they aren't perfect, but I feel that the abundance of evidence we have available to us supports Lion's claim that Letro will reverse (abrogate/destroy) gyno.
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02-21-2005, 04:29 PM #9Originally Posted by hooker
i havent resesarched letro that much, so both were good reads,my point is that if bro's cant get letro, there are other options,here's another, not on letro, but l dex
Safety and efficacy of anastrozole for the treatment of pubertal gynecomastia : a randomized, double-blind, placebo-controlled trial.
Plourde PV, Reiter EO, Jou HC, Desrochers PE, Rubin SD, Bercu BB, Diamond FB Jr, Backeljauw PF.
AstraZeneca Pharmaceuticals LP, Chesapeake 2B-126, 1800 Concord Pike, P.O. Box 15437, Wilmington, Delaware 19850-5437, USA. [email protected]
Pubertal gynecomastia is thought to result from transient imbalances between estrogen and androgen concentrations. Anastrozole (ARIMIDEX ), a potent and selective aromatase inhibitor, decreases estrogen and increases testosterone concentrations in pubertal boys. The safety and efficacy of anastrozole for the treatment of pubertal gynecomastia were evaluated. In a randomized, double-blind, placebo-controlled study of 80 boys, aged 11-18 yr, with pubertal gynecomastia that had not reduced over a 3-month interval, subjects received either anastrozole (1 mg) or placebo once daily for 6 months. A response was defined as a 50% or greater reduction in the calculated volume of both breasts combined using ultrasonography measurements. A comparison of response rates was performed using logistic regression analysis. Secondary end points included changes in serum hormone concentrations. The percentage of patients with a response was 38.5% for the anastrozole group and 31.4% for the placebo group (odds ratio, 1.513; 95% confidence interval, 0.496-4.844; P = 0.47). At 6 months, the median percent change in the testosterone/estradiol ratio was 166% for the anastrozole group and 39% for the placebo group. Anastrozole treatment was well tolerated. In patients with pubertal gynecomastia, no significant difference in the percentage of patients with a 50% or greater reduction in total breast volume, as calculated from ultrasonography measurements, was demonstrated between the anastrozole and placebo groups.
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02-21-2005, 04:37 PM #10Writer
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02-21-2005, 04:40 PM #11Originally Posted by hooker
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02-21-2005, 04:41 PM #12Writer
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Try letro...1-2 squirts/day is all you need....it's alot cheaper than the other compounds available, when you look at it like that.
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02-21-2005, 04:45 PM #13Originally Posted by hooker
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02-21-2005, 08:35 PM #14
running 1.25mg EOD hopefully it will reverse whatever i have while i am on
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02-21-2005, 08:47 PM #15Originally Posted by peaker
Bump
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02-21-2005, 08:49 PM #16Originally Posted by fitnessguy
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02-21-2005, 08:59 PM #17AR-Elite Hall of Famer
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I had a run in with a lump induced by some NPP in the nip i hadnt had surgery on...and i believe i can attest to letrozole helping to reverse and keep away the gyno. My body can handle an hrt dose through 1g of testosterone no problem, but when i started to play with nandrolone , got the feeling of no good. So, Npp was dropped asap and 1.25mg of lions letro, 200mg of b6, and 40-60mg of nolvadex ED went into place that next week and a half to two weeks. gyno hadnt shown up since. just a brief overview of one success story, and why having the proper ancillaries on hand can save you. plan ahead of time, every time.
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02-21-2005, 09:09 PM #18
those studies do not say that it abbrogates gyno tissue, only that it abbrogates the symptoms of the genetic defect, so that's a bit of a misreading. The studies (with the exception of the one in pubescent boys that does not have a statistically significant variation from placebo) all relate to PREVENTION and not treatment of gyno.
We need to be careful not to make a blanket statement on this, but there definitely (vette, hooker, and others) have been anecdotal reports of AI's helping to reduce gyno.
I guess all i'm saying is that while it may work, and seems to have worked on some, don't be too disappointed if it doesn't work on you.
I sincerely hope that everyone that buys an AI for the purpose of reducing gyno has the best of luck, and the utmost success.
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02-21-2005, 09:29 PM #19AR-Elite Hall of Famer
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Originally Posted by Dude-Man
I take studies done on various lab rats, placebo groups, schools in third world countries, etc with a grain of salt more or less. Personal and trusted feedback is key. You are right on, though. Dont be dissappointed if something worked for someone, then not on you. Goes back to understanding exactly what your body chemistry/homeostasis/etc is going through. Bottom line is being prepared and having a gameplan for a worse case senario should do no harm. Have your arsenal close by and know how to use it when and if the time should come.
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02-21-2005, 09:34 PM #20
prevention beats the hell out of correction.
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02-21-2005, 09:37 PM #21Originally Posted by 956Vette
i just ran 1 g of test ew and used nolva 10 mgs ed and .25 mgs of l dex ed, and had no signs of gyno
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02-21-2005, 09:42 PM #22AR-Elite Hall of Famer
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Originally Posted by Dude-Man
Originally Posted by dirtdawg
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02-21-2005, 09:44 PM #23Originally Posted by 956Vette
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02-21-2005, 09:49 PM #24AR-Elite Hall of Famer
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Originally Posted by dirtdawg
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02-21-2005, 10:00 PM #25Originally Posted by 956Vette
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