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  1. #1
    PunkRawk is offline Member
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    estrogen and igf-1

    estrogen plays an important role in the body from what i read...it has something to do with the release of igf-1.....the question is how much estro should be blocked on a mass cycle of over 1 or 2 g's of test...blocking estro with arimidex or proviron seems block the release of igf-1.....so i am wondering if using clomid as a mild anti-e and then arimidex ever 5 days or so would be smart....there has to be a ratio to figure out how much estro we need in our bodies??

  2. #2
    Dr.Evil's Avatar
    Dr.Evil is offline Retired Moderator
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    that´s a good question, but i don´t know if there´s ever been a documented study to answer your question.

  3. #3
    PunkRawk is offline Member
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    well i figured you might know this....lets look it from this angle maybe the two of us and can up with some sort of hypthosis....supposedly nolvadex can kill igf-1 production by up to 24% in people.....nolvadex is a pretty weak anti-e compared to arimidex ....arimidex stops the conversion completely right?? nolva just binds to the receptors....so my train of thought is that arimidex might kill igf-1 completely....and if it does then how are people growing off large mass cycles?? or are they not?? clomid is a synthetic e that has no estrogen like values....it binds to the receptors so that "real" estro can't....i dunno...this is all so confusing...i want the best mass i can get without hindering things due to water retention...seems like 25mg's proviron ed or eod and clomid eod during a cycle might be good and if signs of gyno pop up then hit it hard with arimidex or nolva....

    PUNKRAWK

  4. #4
    Dr.Evil's Avatar
    Dr.Evil is offline Retired Moderator
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    but if less estrogen means less igf-1 then women should have much more igf-1 than men. the mechanism may not be estrogen mediated or estrogen receptor mediated.

  5. #5
    PunkRawk is offline Member
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    wait i think i read this somewhere....progesterone and igf-1 work together in the female body....i need to go dig up some info...

  6. #6
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    TxLonghorn is offline Junior Member
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    Well, I may have this mis-remembered, but arimidex won't lower igf-1 as much as nolva. In fact, I seem to recall reading that nolva could lower igf-1 levels by ~58%, clomid ~31%, and arimidex ~18%.

    Letrozole , which is the next generation anti-e will actually increase igf-1 levels.

    What I would like to know is the whole fina/gyno issue. Is it prolactin, igf-1, WHAT?

  7. #7
    D00fy's Avatar
    D00fy is offline Anabolic Member
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