Anabolics
Search More Than 6,000,000 Posts
Results 1 to 7 of 7
  1. #1
    LeanMeOut's Avatar
    LeanMeOut is offline Community Veteran
    Join Date
    Jan 2004
    Location
    One up on you
    Posts
    4,446

    Androgens, Estrogens, and The Immune Response

    Androgens, Estrogens, and The Immune Response
    Originally posted by Liftsiron @ PM


    Posted by Nandi12



    Androgens, Estrogens, and The Immune Response
    I posted this reply recently on another board to the question "Do androgens suppress or stimulate the immune system"

    It's really not quite correct to say androgens suppress or stimulate the immune system. It is a bit more complicated than that, not surprisingly.

    Here is Immunology 101 in a nutshell. The immune system has two "arms of attack": the cell mediated arm and the humoral arm. The cell mediated arm, or cellular immunity, responds to general assaults on the body by sending out immune cells to do things like attack invading organisms, or degrade necrotic tissue, in a non specific manner. By non specific it is meant that the immune cells do not recognize the invader as a specific target with which they are familiar. Inflammation is an example of a cell mediated response. When you get a sliver or strain a muscle the body sends immune cells there to wall off the site, increase blood flow, remove damaged tissue, etc.

    Humoral immunity involves B lymphocytes that secrete antibodies that bind to the target and allow immune cells to recognize the target immediately as an invader and launch an attack. When you are vaccinated for something, like smallpox, you are injected with a small inactive piece of the virus. This primes your body to make large numbers of B cell clones that, if ever challenged with smallpox for real, pump out antibodies that mark the virus for destruction by other cells. The big advantage of this system is that it is fast and efficient. The disadvantage is that it is very specific. The cellular response is not as efficient but it works against any invader, not just one for which there already exist primed clonal B cells.

    There is an emerging model of how the sex steroids regulate the two arms of the immune system. It is thought that testosterone stimulates the humoral arm and suppresses the cellular arm. This paradigm arose from the study of autoimmune diseases which overwhelmingly plague women more than men. The majority of autoimmune diseases involve a cellular immune system gone wild. Since in men testosterone suppresses cellular immunity, men are much less likely to suffer from these diseases, like rheumatoid arthritis.

    So when NFG123 mentioned that androgens are antiinflammatory, this is kind of what it means technically. Some steroids seem to have stronger effects than others. So when people say deca improves joints because it makes you hold water, that is nonsense. It is an antiinflmmatory because it suppresses cell mediated immunity, which controls inflammation. it has nothing to do with water.

    Why is deca's reputation as an antiinflammatory better than testosterone's for example? My guess is the minimal aromatization and its progestogenic activity. If you link to the article below and open the graphic, you will see a couple of interesting things.

    First, progesterone, like testosterone, stimulates humoral immunity (the TH2 mediated response in the graphic) and suppresses cellular immunity (TH1 response). So progesterone has antiinflammatory action.

    Second, estrogen exerts a biphasic effect. At low doses it is proinflammatory, stimulating the TH1 arm of the immune system (cellular immunity) and inflammation.

    Deca then works both as an androgen and a progestin to quell inflammation. Testosterone, by virtue of its aromatization to estrogen is an inferior antiinflammatory.

    If you want to learn more about sex hormones and immunity, this is a good article to start with


    http://www.sciencemag.org/cgi/conten...=JsdA5F3s0DHFo
    Last edited by LeanMeOut; 03-14-2005 at 05:01 PM.

  2. #2
    Britguy is offline Banned
    Join Date
    Jun 2003
    Posts
    352
    good find, informative

  3. #3
    Blown_SC is offline Retired Vet
    Join Date
    Feb 2004
    Location
    Canada
    Posts
    6,917
    Nice post holmes...

  4. #4
    jbol's Avatar
    jbol is offline Senior Member
    Join Date
    Dec 2003
    Location
    On the End of a Needle
    Posts
    1,814
    bump 4 a good post

  5. #5
    Join Date
    Apr 2002
    Posts
    2,393
    Quote Originally Posted by LeanMeOut
    Androgens, Estrogens, and The Immune Response

    Posted by Nandi12

    I'd urge everyone to read anything they can by Nandi12 (now just called Nandi, I believe). He does a bit of writing on SynergyMuscle (where he and I mod), and is, in my estimation, the best Mod on the 'Net.

    When I needed help on my Benadryl theory, he's the dude I turned to....

  6. #6
    Blown_SC is offline Retired Vet
    Join Date
    Feb 2004
    Location
    Canada
    Posts
    6,917
    Quote Originally Posted by hooker
    I'd urge everyone to read anything they can by Nandi12 (now just called Nandi, I believe). He does a bit of writing on SynergyMuscle (where he and I mod), and is, in my estimation, the best Mod on the 'Net.

    When I needed help on my Benadryl theory, he's the dude I turned to....
    Yes, I don't post much on the boards he mods, but he's made countless great threads/posts....

  7. #7
    Join Date
    Apr 2002
    Posts
    2,393
    He's a great scientific mind. The only downfall is the "readability" of his articles (i.e. his writing style is a bit dry)...

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •