04-12-2002, 11:26 AM #1
Want to minimize aromatase activity? (GOOD READ)
Want to minimize aromatase activity? Stay lean!
For those of you who want to either reduce your anti-E dosage or those of you who don't use any anti-E while cycling, this may be of interest.
Basically, adipose tissue is a major site of extra-gonadal aromatase activity in humans. Logical reasoning then follows that the fatter you are, the more aromatase activity you will likely exhibit. From this rationale, the conclusion can be made: stay lean, especially while on right? Yea, but wait. You don't want to stay too lean or you'll sacrifice gains, so you have to decide how to optimally approach this situation. I believe the best approach would be to do a cutting diet before your cycle to reduce bodyfat levels. This would allow you more of a "get fat" window while on without dramatically increasing aromatase activity. Now one could argue that because we are flooding our body with exogenous androgens, conversion to estrogen may be somewhat adipose-tissue independent. This may be true in that other aromatase synthesis sites may compensate for a decreased aromatase activity in fat, but even so, by losing adipose tissue you have still reduced the capacity of aromatase to a certain extent.
Check out the following abstract relating fat to aromatase. (and we're not even talking about effects on insulin and leptin)
Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. Cohen PG.
Med Hypotheses 2001 56(6): 702-8
In males, aging, health and disease are processes that occur over physiologic time and involve a cascade of hormonal, biochemical and physiological changes that accompany the down-regulation of the hypothalamic-anterior pituitary-testicular axis. As aging progresses there are relative increases of body fat and decreases in muscle mass. The increased adipose tissue mass is associated with the production of a number of newly generated factors. These include aromatase, leptin, PAI-1, insulin resistance, and the dyslipidemias, all of which can lead to tissue damage. Fatty tissue becomes the focal point for study as it represents the intersection between energy storage and mobilization. The increase in adipose tissue is associated with an increase in the enzyme aromatase that converts testosterone to estradiol and leads to diminished testosterone levels that favor the preferential deposition of visceral fat. As the total body fat mass increases, hormone resistance develops for leptin and insulin. Increasing leptin fails to prevent weight gain and the hypogonadal-obesity cycle ensues causing further visceral obesity and insulin resistance. The progressive insulin resistance leads to a high triglyceride-low HDL pattern of dyslipidemia and increased cardiovascular risk. All of these factors eventually contribute to the CHAOS Complex: coronary disease, hypertension, adult-onset diabetes mellitus, obesity and/or stroke as permanent changes unfold. Other consequences of the chronic hypogonadal state include osteopenia, extreme fatigue, depression, insomnia, loss of aggressiveness and erectile dysfunction all of which develop over variable periods of time.
---REFERENCE DR X-----
04-12-2002, 07:10 PM #2
which leads me to the next issue.. the advantage of fat people in the transexual community
04-12-2002, 07:12 PM #3
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