NOLVADEX actually INCREASING ESTROGEN LEVELS????
This quote is from Anabolic Review's steriod description of Nolvadex....???
"A very rare but all the more serious problem of Nolvadex is that in some cases it does not lower the estrogen level but can increase it."
What do ya think? I've experienced worsening bitch tit symptoms with Nolvadex before....
Anyone ever hear of "AROMASTIN 25mg"..... My connection says these are the BEST anti-estrogens, but they are $300 for 20 tabs!!!! :eek:
Re: NOLVADEX actually INCREASING ESTROGEN LEVELS????
Quote:
Originally posted by Magnum357
This quote is from Anabolic Review's steriod description of Nolvadex....???
"A very rare but all the more serious problem of Nolvadex is that in some cases it does not lower the estrogen level but can increase it."
What do ya think? I've experienced worsening bitch tit symptoms with Nolvadex before....
Anyone ever hear of "AROMASTIN 25mg"..... My connection says these are the BEST anti-estrogens, but they are $300 for 20 tabs!!!! :eek:
food for thought:
Kiang DT; Kollander RE; Thomas T; Kennedy BJ. Up-regulation of estrogen
receptors by nonsteroidal antiestrogens in human breast cancer. Cancer Res 1989
Oct 1;49(19):5312-6.
Development of resistance to hormonal therapy in breast cancer is frequently
associated with a decline or loss of cellular estrogen receptors. Agents which
up-regulate the receptor may reduce the incidence of hormonal resistance.
Antiestrogens at concentrations ranging from 0.1 to 1 microM produced a 2- to
4-fold increase of estrogen receptors in MCF-7 and T-47D breast cancer cells.
This increase, which occurred as early as 3 h and was sustained throughout the
4 days of continuous exposure to tamoxifen, was primarily due to an enhancement
in receptor synthesis.
Re: Re: NOLVADEX actually INCREASING ESTROGEN LEVELS????
BUMP
Quote:
Originally posted by jbrand
food for thought:
Kiang DT; Kollander RE; Thomas T; Kennedy BJ. Up-regulation of estrogen
receptors by nonsteroidal antiestrogens in human breast cancer. Cancer Res 1989
Oct 1;49(19):5312-6.
Development of resistance to hormonal therapy in breast cancer is frequently
associated with a decline or loss of cellular estrogen receptors. Agents which
up-regulate the receptor may reduce the incidence of hormonal resistance.
Antiestrogens at concentrations ranging from 0.1 to 1 microM produced a 2- to
4-fold increase of estrogen receptors in MCF-7 and T-47D breast cancer cells.
This increase, which occurred as early as 3 h and was sustained throughout the
4 days of continuous exposure to tamoxifen, was primarily due to an enhancement
in receptor synthesis.