Accutane question again...
Okay ... what I'm wondering is... if you were to do Accutane before a cycle, would the atrophy of the sebaceous glands REDUCE the potential for acne? I guess the most qualified person to answer this is a person who ...
Ran a cycle, had acne ...
THEN ...
Did Accutane for a while...
THEN ...
Did another cycle ...
I'm looking to see if the AAS induced acne can be minimized by having ran accutane inbetween them.
thanks
I posted this elsewhere...
Quote:
Originally Posted by Defconx3
Great post GoldenFloyd, there is not an abundance of information about accutane related to BBers and gear, so your input is very helpful.
The post below was in response to an inquiry about using accutane while on cycle. See the original thread here: http://67.18.108.244//showthread.php?t=179219
Note how my cholesterol has shot up recently due to other factors - diet and alcohol in my opinion. Also, I was going overkill on the fish oil - 30g a day or so. My statistically-irrelevant "experiment" was to see if over-dosing on omega-3 fatty acids while on cycle and accutane would be beneficial for the blood lipid profile. My conclusion is that it is "not enough" - at least when having BBQ and beer. The take away is to always be careful and always monitor your lipid profile and liver values when using Accutane.
-------------
Accutane is not an anti-biotic bro. Yes, my acne is all gone. It helps to know the basics of what makes your skin break-out.
Why You Get ACNE
1) Excess Oil Production: My understanding is that your body's pores produce sebum (the slick grease that comes out of your pores). The more sebum you produce, the more likely you are to get clogged pores and develop an any one of several types of "infections" - acne, whitehead, blackhead, cystic acne, etc.
2) p. acnes bacteria: This infection is caused by bacteria getting in the pore and, with the sebum, clogging the shit out of it. Sebum has the effect of trapping outside dirt and bacteria in the pore - if it sits in the pore too long it will develop the aforementioned infection.
3) clogged skin pores: 3 = 1 + 2, from above.
4) Inflammation: inflammation causes the buildup of under-the-skin puss that results in a whitehead with a red ring around it. This is to be compared with a blackhead where it is just an open pore packed with dirt and other shit (basically not infected or inflamed).
ACNE while Cycling
Now, your body produces more sebum (everyone is different) with increased hormone levels (testosterone) and the time you are "most susceptible" is when your body is fluctuating in it hormones - beginning of the cycle when you ramp up (like going through puberty) and the end of the cycle while you are doing PCT to come down and try to maintain a steady level of hormones in your system. People who run accutane through their cycle and not through their PCT will oftentimes see a recurrence of the acne as a result of their still fluctuating hormone levels. Knowing this and knowing that a doctor prescribed regimen on accutane lasts 4-6 months, people with acne problems plan their cycles accordingly.
Most Common Types of Prescribed Medicines
Antibiotics - the "cyclines" family of drugs - monocycline, doxcycline (effective against inflammatory acne), tetracycline (the others are considered derivatives of tetracycline). are antibiotics and fight against the bacterial infection of the pore.
Accutane, isotretinoin, is not an anti-biotic: it is a massive dose of concentrated synthetic Vitamin A and belongs to the retinoid family of acne remedies. It actually attacks all four of the causes of acne above - reducing sebum production, unclogging pores, reducing inflammation, and fighting the p. acnes bacteria. This is the reason that you get really really dry on accutane and not on antibiotics - two seperate mechanisms for fighting acne.
Topical Anti-microbials: topical solutions that are like antibiotics, attacking the proliferation of P. Acnes. You may have seen names like Clindamycin, Benzoyl Peroxide (no need for prescription in US), Azelaic acid, Erythromycin, or sodium sulfacetamide.
Topical Retinoids: think of these like topical accutane, but much much less effective in treating severe acne. To the best of my knowledge these fight to unclog pores, attack P. acnes, and prevent inflammation, but not the production of sebum, which requires an internal remedy like Accutane. Still, these seem to work for a lot of people, but not as handy as popping 1 or 2 pills a day. You may have seen brand names like Adapalene, Tazarotene, or Tretinoin.
A Homebrew Method
Incidentally, you will read people saying that putting dishwashing fluid on the acne seems to "dry it out" - well, it is kind of funny but logical when you think about it - "dawn cuts the grease" and "antibacterial" are a double-pronged attack against clogged pores. My theory is that the "cutting grease" agent used in those dishwashing soaps polarizes the grease and push it out of your pores while the antibacterial property of the soap works to kill the bacteria that would result in an infection if it clogged the open pores. Most people I have read about find success with this on their body - back and chest - but I have never tried it. It might be a nice homebrew method without the liver or other accutane risks though and worth investigating if you have the time.
Personal Opinions
Anyway, to answer, accutane absolutely works against acne. You have to be ready to deal with the sides of a lot of dryness, possible reduced vision during nighttime, possible depression (very very debateable - how much of "depression" attributed to Accutane is psychosomatic and how much is real? My own opinion is that if you have no depression, I wouldn't worry about it on accutane. But there are a lot of angry parents out there who sleep better a night knowing that their kids committed suicide because of Accutane and not inattention to early signs of problems - see some of their stories here: http://www.state.nj.us/lps/ca/bme/accutane.htm and for some heavy subcommittee reading here: http://energycommerce.house.gov/107/action/107-143.pdf ), possible muscle aches, and.... oh yea, NO ACNE.
If you have any more concerns about accutane or fighting acne in general, ask away, I consider myself a veteran of keeping the skin clean.
Also, do research on www.acne.org. I've never tried ProActiv (I think they may be a sponsor of that site), but the information posted there is real and informative. Another good site is: http://www.skincarephysicians.com/acnenet/index.html
Dude, this will not make or break your cycle in my opinion. If you have a skin problem that is getting out of hand and not responding to doctor prescribed remedies, get on the accutane and keep pumpin and shooting. When faced with a cycle impacting conundrum, it is always useful to remember that a vast majority of your gains are made at the dining table, in bed, and with your intensity in the gym - all elements that remain 100% under your control. GOOD LUCK.
--------------------
ps, I am on an ORAL AAS (among other things AAS and non-AAS) and on ACCUTANE and my liver values are within normal range:
06/12/05 ALT: 28 -< 36 (PERFECT-O)
05/13/05 ALT: 38 -< 36 (SLIGHTLY ELEVATED)
04/15/05 ALT: 37 -< 36 (SLIGHTLY ELEVATED)
People with liver disease get 3 digit numbers for ALT. My dermo joked that he and his med buddies would work hard on trying to get their ALT as high as possible (binge drinking). Not to make light of the situation because everyone reacts differently to these things (who knows, maybe you have liver problems in your family)... but accutane isn't necessarily the death knell for a cycle. That said, you should always cycle ONLY when you have everything together (anti-es, PCT, etc) so if something unforeseen like this comes up, you can deal with it accordingly. This is your health, after all.