Search More Than 6,000,000 Posts
Results 1 to 2 of 2
  1. #1
    supplementsavvy is offline Junior Member
    Join Date
    Mar 2005

    Thyroid myths? A must read for those who use T3,T4 and Triac

    Over at Avant Labs I read a very interesting article on thyroid function written by Karl Hoffman. He covers the basics of thyroid function but goes on to state something that most bbers would scoff at: long-term use of thyroid preparations is not nearly as suppressive as long-term use of anabolic steroids . In fact, even after years of exogenous thyroid hormone administration, the thyroid's function will return within a month after discontinuing meds. These statements are backed up with solid references as well. What do you guys think of this?

    Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy.

    Vagenakis AG, Braverman LE, Azizi F, Portinay GI, Ingbar SH.

    The pattern of thyrotropin secretion was analyzed in seven euthyroid women, before and after withdrawal of long-term thyroid hormone, by serial measurements of thyroid 131l uptake, serum thyroxine, tri-iodothyronine, and thyrotropin concentrations, and the response to thyrotropin-releasing hormone. During exogenous hormone administration, 131l uptake was suppressed, and serum thyrotropin concentrations before and after administration of thyrotropin-releasing hormone were undetectable. After withdrawal of exogenous hormone, thyrotropin secretory function was transiently impaired, as indicated by undetectable basal thyrotropin concentrations together with absence of response to thyrotropin-releasing hormone, and subsequently by normal values of basal thyrotropin concentration and normal responses to releasing hormone while serum thyroxine and tri-iodothyronine concentrations were subnormal. Decreased thyrotropin reserve persisted for two to five weeks. Detectable values of serum thyrotropin (less than 1.2 muU per milliliter) and a normal 131l uptake usually occurred concurrently in two to three weeks. Serum thyroxine concentration returned to normal at least four weeks after hormone withdrawal.

    PMID: 808728 [PubMed - indexed for MEDLINE]

    "In 1951, Greer reported the pattern of recovery of thyroid function after stopping suppressive treatment with thyroid hormone in euthyroid [normal] subjects based on sequential measurements of their thyroidal uptake of radioiodine. He observed that after withdrawal of exogenous thyroid therapy, thyroid function, in terms of radioiodine uptake, returned to normal in most subjects within two weeks. He further observed that thyroid function returned as rapidly in those subjects whose glands had been depressed by several years of thyroid medication as it did in those whose gland had been depressed for only a few days"

  2. #2
    Jerzey's Avatar
    Jerzey is offline Registered User
    Join Date
    Jun 2005
    Good read, thanks!

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts