Thread: when to shoot hcg
08-08-2005, 11:46 AM #1Junior Member
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- Apr 2004
08-08-2005, 11:48 AM #2Associate Member
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- Aug 2005
two weeks should be good start with 2500 iu's then 1500 iu's every5 days for two weeks.
08-08-2005, 11:48 AM #3
many opinions on this...im going to try 400iu ED for 10 days leading up to a few days before starting clomid
08-08-2005, 11:49 AM #4
The very next day. I would hit 1000iu for 10 days strait with some nolva and hit clomid when the last ester clears your system(look at 18-21 days).
08-08-2005, 07:47 PM #5
08-08-2005, 08:07 PM #6
Bros using it during the cycle is best, but if you're going to use before pct, don't go over 300-400 ed for 10 day. Here's a study showing low doese are better then one high dose, so can you imagine what would happen with more then one high dose?
Posted by hhajdo at S’ology
Differential effect of single high dose and divided small dose administration of human chorionic gonadotropin on Leydig cell steroidogenic desensitization.
Smals AG, Pieters GF, Boers GH, Raemakers JM, Hermus AR, Benraad TJ, Kloppenborg PW.
This study compared the effect of a single high dose of hCG (1500 IU) with that of the same dose administered in multiple small doses (300 IU, once daily for 5 days) on Leydig cell steroidogenesis. Administration of a single high dose of hCG to seven healthy men raised the mean plasma testosterone (T) level to peak levels 2.1 +/- 0.2 (SEM) X the baseline value at 48 h. Thereafter plasma T decreased to below normal (0.7 +/- 0.1 X baseline) 7 days after the injection. The mean 17-hydroxyprogesterone (17-OHP) level peaked at 24 h (2.5 +/- 0.2 X baseline) and then also fell to a nadir value of 0.6 +/- 0.2 X baseline on day 7. Reflecting the early accumulation of 17-OHP over T, the 17 OHP/T ratio reached its maximum (1.6 +/- 0.1 X baseline) at 24 h at the same time when plasma estradiol [(E2) 4.4 +/- 0.6 X baseline] and the ratio E2/T (2.7 +/- 0.3 X baseline) achieved their maximal values. Administration of 1500 IU hCG in five divided doses of 300 IU daily increased the mean plasma T levels to peak value of 2.1 +/- 0.2 X baseline at 5 days and the levels remained elevated thereafter. The response of T as reflected by the area under the curve was almost twice as great as in the single dose study (2844 +/- 360 vs. 1647 +/- 214). In contrast to the single high dose experiment, mean plasma 17-OHP levels in the divided dose protocol did not peak at 24 h but only gradually increased. As the increase of T exceeded the 17-OHP increase at almost all time intervals, no accumulation of 17-OHP over T occurred as in the single dose experiment. Instead the 17-OHP/T ratio fell to a nadir value of 0.6 +/- 0.1 X baseline on day 7. The initial E2 peak was absent in the divided dose protocol and the E2/T ratio only marginally increased. Considering both experiments together a close relation was found between the hCG-induced increases in E2 and 17-OHP (r = +0.88, P less than 0.001), as well as the ratio 17 OHP/T (r = +0.64, P less than 0.02).
08-08-2005, 08:32 PM #7Associate Member
Originally Posted by 01dragonslayer
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08-09-2005, 06:30 PM #8
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