05-01-2002, 01:12 PM #1
Thought this would be of interest - effects of 17aa on the prostate
I was reading a threat the other day that asked for the diff between androgenic and anabolic sterioids, ill find a good article for that quickly but i found this when i was in the library the other day... what you guys think?
*this article is for the guy who asked about prostate cancer and gear
Intratesticular leiomyosarcoma in a young man after high dose doping with oral-turinabol : A case report.
AB: BACKGROUND: Androgenic anabolic steroids have been suspected of activity as carcinogens in the development of carcinoma and angiosarcoma of the liver and adenocarcinoma of the prostate. Although the proliferation of smooth muscle cells is stimulated by sexual steroids , to the authors' knowledge a possible relation between androgenic anabolic steroids and the development of leiomyosarcoma has not previously been reported in humans. METHODS: A 32-year-old man underwent right radical orchiectomy for a tumor of the upper pole of the right testicle. Routine histopathologic examination and immunohistochemical staining were performed. RESULTS: The tumor was identified as an intratesticular leiomyosarcoma based on its typical growth pattern and the characteristic immunohistochemical staining profile. The patient reported a 5-year history of systematic use of high dose Oral-Turinabol (4-chloro-1-dehydro-17alpha-methylteststerone) that began at age 18 years and stopped approximately 9 years before presentation. CONCLUSIONS: The rarity of intratesticular leiomyosarcoma, the experimental induction of similar tumors in animals by androgens and estrogens, and the unusually young age at presentation of the patient in the current study support the hypothesis that high dose doping with androgenic anabolic steroids could have played a cocarcinogenic role in the development of the tumor in this case.
05-01-2002, 01:20 PM #2
Here is another one...
Chronic anabolic -androgenic steroid treatment affects brain GABA-A receptor-gated chloride ion transport.
Previous research in this laboratory has shown that chronic treatment of adult male rats with an anabolic-androgenic steroid (AAS) produced anxiolytic behavior and increased the functional response of cortical gamma-aminobutyric acid-A (GABA-A) receptors. The experiments reported here were aimed at further characterizing the effect of chronic AAS exposure on cerebral cortical GABA-A receptors. Adult male rats were injected with dianabol (1,4-androstadien-17-alpha-methyl-17-beta-ol-3-one; 10 mg/kg/day, SC) for 4 weeks. A significant decrease in ventral prostate gland weight was found after 2 weeks of dianabol, and returned to control levels 3 and 10 days after steroid discontinuation. Testicular weights decreased throughout the treatment period but reached statistical significance only during the withdrawal period. Serum 3-alpha-androstanediol level was marginally increased after 2 weeks of dianabol injection, and was significantly decreased at 3 and 10 days after withdrawal. GABA-stimulated 36chloride (Cl-) influx in cortical synaptoneurosomes was increased in animals treated with dianabol for 2 and 4 weeks, and remained elevated 3 days after dianabol withdrawal, returning to control levels at withdrawal day 10. The increase in receptor efficacy was associated with a transient increase in receptor sensitivity (inverse of EC-50), apparent after 2 weeks of AAS treatment and at withdrawal day 3. In a follow-up experiment, metabolites of dianabol were tested for the in vitro efficacy in potentiating GABA-stimulated Cl- transport. Only 3-alpha-androstanediol and androsterone were found to have potent stimulatory effects. The 3-beta-reduced metabolites were inactive, as were metabolites that contained a methyl group at the 17-alpha position. These results point to significant facilitative effects of dianabol treatment on brain GABA-A receptors via the metabolic formation of neuroactive steroids .
05-01-2002, 01:21 PM #3Associate Member
- Join Date
- Oct 2001
Regular self examination of the testicles is important. This proves it.
05-01-2002, 01:51 PM #4
I recently checked out info on Oral-Turinabol ,and it suggested that prolonged use is OK. The kid was young and probably uneducated at the time and was munching on Oral-Turinabol non-stop, so his case looks pretty exceptional. This drug was very popular in Eastern Germany, and if it was a real threat, we would hear a lot more about it. Oral-Turinabol is supposed to be far less harmful than D-bol.
05-01-2002, 03:32 PM #5G-S Guest
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