
Originally Posted by
hooker
Actually, it barely binds to the AR, THW....it's a very weak binder to the AR, in other words(1). So yeah, despite being an androgen, it's got a low(ish) androgenic rating, and it isn't going to be really hot for increasing libido, I think. It works for some, however...
Anyway...
In light of this weak receptor binding, Dianabol's actions have long been suspected to have alot to do with non-receptor mediated action (since it barely binds to the AR, yet has a pronounced anabolic effect). This may be explained by a study in rats who have had their pituitary glands removed, dianabol exhibited no anabolic activity(2), which tells us that Dbol probably exerts most of it's anabolic effects via GH-induced mechanisms. This is also why people (Drummerboy, HE-MAN, etc...) say that Dbol soothes their joints, I suspect. But GH doesn't do alot (anecdotally, at least) for libido in normal males.