cycle affected by glutamine?

[TallMan]

No, dude, it's someone else. He has been complaining on a dutch board that his ass is hurting. He's a real *****.
http://www.dutchbodybuilding.com/for...ad.php?t=47109

ooooom olliee ! ben ne fan van jou man, wanneer ga je weer eens rel schoppen op DBB ?

ontopic//hahaha Big,r gets owned

[Mesomorphyl]

word.

For the rest of you guys: Go **** meso's ass!!! (****ing assholes, y'all from the south or something??)

@ uncle ollie : kanker stuk vreten tyfuslyer, ga maar ergens anders de homo uithangen verrader

jezurd defending his boy friend... big'r jezurd & boerenkool

Hey jezurd & boerenkool... which one of you guys is on top and which one is on bottom?

[Pinnacle]

No, dude, it's someone else. He has been complaining on a dutch board that his ass is hurting. He's a real *****.
http://www.dutchbodybuilding.com/for...ad.php?t=47109

LMAO...Meso is a star in Holland!!!

[big'r]

ooooom olliee ! ben ne fan van jou man, wanneer ga je weer eens rel schoppen op DBB ?

ontopic//hahaha Big,r gets owned

Time to do some owning myself
Glutamine. The final verdict!!!!!

Glutamine production in muscle protein is 50% lower than assumed
-Results of tracer studies indicate that skeletal muscle contributes to approximately 70% of overall glutamine production in healthy adults; the contribution of de novo synthesis being estimated at approximately 60%. Direct and specific measurements of glutamine in intact muscle protein are 50% lower than assumed previously (G1).

Most amino acids are precursors for alanine and glutamine synthesis in skeletal muscle
-Cysteine, leucine, valine, methionine, isoleucine, tyrosine, lysine, and phenylalanine increase the rate of glutamine synthesis. The progressive decline in alanine and glutamine synthesis noted on prolonged incubation is prevented by the addition of amino acids to the incubation medium (G2)

90% of the glutamine you take orally never even makes it to your muscles. Glutamine supplementation decreases it's own synthesis and mostly turns itself into glucose.
-Systemic glutamine administration is ineffective in preventing muscle depletion, due to a relative inability of skeletal muscle to seize glutamine from the bloodstream. Transport from blood accounts for only 25% of the intramuscular glutamine pool turnover. In contrast, the intracellular pools of most essential amino acids, such as phenylalanine or leucine, derived largely from the extracellular space. Studies involving oral ingestion of stable isotope-labelled glutamine indicate that 50-70% of enterally administered glutamine is taken up during first pass by splanchnic organs (gut and liver). (G14).
-Glutamine orally is successful in elevating plasma glutamine at the peak concentration by 46%, which suggests that a substantial proportion of the oral load escaped utilization by the gut mucosal cells and uptake by the liver and kidneys. If the entire glutamine dose had been distributed within the blood (8% body wt) and extracellular fluid (20% lean body mass) compartments, then a 3-mM rise in blood glutamine concentration might have been expected, whereas plasma glutamine concentration was only observed to rise by 0.3 mM. This might suggest that only 10% of the oral dose reached the extracellular fluid compartments (G15).
-Infusion of glutamine increases plasma glutamine concentration and turnover only threefold, formation of glucose from glutamine increased sevenfold. Furthermore, glutamine infusion decreased its own de novo synthesis (4.55 +/- 0.22 vs. 2.81 +/- 0.62 micromol x kg(-1) x min(-1);P < 0.02) (G16).

Glutamine does not prevent exercise-induced immune impairment. Carbs do. And glutamine does not influence hormonal levels
-Consuming 30-60 g carbohydrate x h(-1) during sustained intensive exercise attenuates rises in stress hormones such as cortisol and appears to limit the degree of exercise-induced immune depression. Convincing evidence that so-called 'immune-boosting' supplements, including high doses of antioxidant vitamins, glutamine, zinc, probiotics and Echinacea, prevent exercise-induced immune impairment is currently lacking (G31).
-Intracellular glutamine concentration may not be compromised when plasma levels are decreased postexercise. In addition, a number of recent intervention studies with glutamine feeding demonstrate that, although the plasma concentration of glutamine is kept constant during and after acute, strenuous exercise, glutamine supplementation does not abolish the postexercise decrease in in vitro cellular immunity, including low lymphocyte number, impaired lymphocyte proliferation, impaired natural killer and lymphokine-activated killer cell activity, as well as low production rate and concentration of salivary IgA (G32).
-Glutamine supplementation abolished the postexercise decline in plasma glutamine concentration but had no effect on lymphocyte trafficking, NK and lymphokine-activated killer cell activities, T cell proliferation, catecholamines, growth hormone , insulin , or glucose (G33).
-Nutritional supplementation with glutamine abolishes the exercise-induced decline in plasma glutamine, but does not influence post-exercise immune impairment. However, carbohydrate loading diminishes most exercise effects of cytokines, lymphocyte and neutrophils (G34).

Glutamine does not increase protein synthesis
-Intravenous infusion of amino acids increases the fractional rate of mixed muscle protein synthesis, but addition of glutamine to the amino acid mixture does not further stimulate muscle protein synthesis rate in healthy young men and women (G6).
-Short intravenous infusion of glutamine does not acutely stimulate duodenal protein synthesis in well-nourished, growing dogs (G8).

Glutamine prevents protein degradation but not more effectively than carbs
-0,9 g/kg glutamine during resistance training has no significant effect on muscle performance, body composition or muscle protein degradation compared to 0,9 g/kg maltodextrin (G9).
-Glutamine preserves protein synthesis in Caco-2 cells submitted to "luminal fasting", but higher glutamine doses did not enhance protein synthesis beyond control fed values. And glucose supplementation restored FSR as effi-ciently as glutamine (G10).

Carbhohydrate or BCAA supplementation prevents decrease in glutamine levels during exercise
-Carbohydrate supplementation affects positively the immune response of cyclists by avoiding or minimizing changes in plasma glutamine concentration (G11).
-Following an exercise bout, a decrease in plasma glutamine concentration can be observed, which is completely abolished by BCAA supplementation (G12).
-BCAA supplementation during a triathlon completely prevents the decrease in plasma glutamine (G13).
-7 distance runners reduced muscle gycogen. A high carb meal (80% carbs) before 60 min. exercise increases plasma glutamine. A 14 h fast before exercise does not change plasma glutamine. Plasma BCAA did not change under either dietary condition (G17).

Fasting decreases glutamine transport. And supplementation during fasting does not prevent muscle loss
-During fasting, skeletal muscle exports increased amounts of glutamine (Gln) while increasing the production of this amino acid by glutamine synthetase (GS) in order to maintain the intramuscular Gln pool (G41).
-Background: One of the major activities of the enterocyte is amino acid transport, which is important not only for the organism but also for the integrity of the mucosa. Bowel rest during the postoperative period is marked by decreased calorie and protein intake with atrophy of the brush border mucosa.
Fasting for 72 hours decreases glutamine and arginine transport. Alanine MeAIB, and leucine transport were maintained (G42).
-0.35 g/kg glutamine/day does not prevent loss of lean muscle in athletes during a 12-day weight reduction program (G43).

Glutamine does not enhance performance
-6 resistance-trained men performed weightlifting exercises after ingesting 0.3 g/kg glutamine. This did not enhance performance (G22).



REFERENCES

(G1) http://www.ncbi.nlm.nih.gov/entrez/q...016&query_hl=1
(G2) http://www.ncbi.nlm.nih.gov/entrez/q...059&query_hl=1
(G6) http://www.ncbi.nlm.nih.gov/entrez/q...116&query_hl=1
(G7) http://www.ncbi.nlm.nih.gov/entrez/q...808&query_hl=1
(G8) http://www.ncbi.nlm.nih.gov/entrez/q...312&query_hl=1
(G9) http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
(G10) http://ajpgi.physiology.org/cgi/content/full/285/1/G128
(G11) http://www.ncbi.nlm.nih.gov/entrez/q...341&query_hl=1
(G12) http://www.ncbi.nlm.nih.gov/entrez/q...939&query_hl=1
(G13) http://www.ncbi.nlm.nih.gov/entrez/q...884&query_hl=1
(G14)http://www.ncbi.nlm.nih.gov/entrez/q...750&query_hl=5
Complete studie: http://forum.bodybuilding.com/showth...16#post7234016
(G15)http://jap.physiology.org/cgi/content/full/86/6/1770
(G16)http://ajpendo.physiology.org/cgi/co...act/272/3/E437
(G17)http://www.ncbi.nlm.nih.gov/entrez/q...952&query_hl=1
(G22)http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
(G31)http://www.ncbi.nlm.nih.gov/entrez/q...437&query_hl=1
(G32)http://www.ncbi.nlm.nih.gov/entrez/q...472&query_hl=1
(G33)http://www.ncbi.nlm.nih.gov/entrez/q...663&query_hl=1
(G34)http://www.ncbi.nlm.nih.gov/entrez/q...210&query_hl=1
(G41)http://www.ncbi.nlm.nih.gov/entrez/q...760&query_hl=1
(G42)http://www.ncbi.nlm.nih.gov/entrez/q...166&query_hl=1
(G43)http://www.jssm.org/vol2/n4/7/v2n4-7pdf.pdf

[Jnrmrplymouth]

This has to be the craziest thread I have ever seen on a bodybuilding forum before. Lets cut to the chase here. This is bodybuilding right. Anyone can put up studies saying 'glutamine doesnt work' and anyone can have all the brains in the world when it comes to bodybuilding but at the end of the day its how big you are that matters. So here we go............talk all you want big'r but why dont you tell us how big you are. Age, weight, height, years training, cycle experience etc etc. If your 250lbs well start to take you seriously but if your 160lbs then get out.

[stupidhippo]

that has nothing to do with anything... All in all lots of controversial evidence here. Havent looked at em in detail but all in all we can say that its not a clear cut issue. I for one aint that convinced to either direction.

[stupidhippo]

Im leaning towards adding glutamine once again to my supplelent list to try once more. Previous attempts I noticed nothing..

[Zelda]

Whahaha, you guys are so incredibly pathetic. The only answer you have is accusations of homosexuality and childish pics. How about posting references? big'r has fulfilled his part of the bargain, so doesn't that mean it's your turn now?

[IBdmfkr]

Do you have a identity disorder. How many superegos do you have. Your a strange guy.

[TallMan]

Do you have a identity disorder. How many superegos do you have. Your a strange guy.

Those are his silly friends LOL !

[mike132]

Do you have a identity disorder. How many superegos do you have. Your a strange guy.

that's bigr and his picklepuffin' posse
GD sausage sniffer looks like the skinny crackhead clown from the simpsons.
stats? i bet he's 140lbs soke and wet with his big 10lb dildo hangin from his ass!!!!!!!!!!

[oswaldosalcedo]

****ing crap for glutamine!
i cant believe !

[big'r]

If i cannot win a discussion as regards content, i'm gonna:

-Claim science sucks. It's personal experience that counts, science is theory. Hereby i'm gonna completely ignore the fact that scientific studies are actually looking at personal experience in individuals (only science looks at total groups/populations and eliminates all variables except for the substance tested, which fact i als completely ignore by stating the substance made me feel good, and i gained muchos lbs. I'm sure it was this substance cause..... Eh well, i know for sure anyway.)
-Totally ignore the studies which have been posted. I will not read them cause i allready know for sure the substance works for me, so why should i open my eyes? Damned i instructed people for 20 years, so i must be right. Here i completely ignore the fact that i may have instructed people falsly in the first place. Cause i read these adds 20 years ago and based my advice on these.
-I'm going to claim lot's of phd's, fitness instructors say the substance will benefit me, completely forgetting to read the references (if there are any at all) and check for myself if the instructor could in any way conclude his writing from these references. Why should i be critical, i can be dumb, the instructor thinks for me. I have never checked pubmed for anything and never will!
-And when i'm really feel like i'm loosing the discussion i'm going to ask for your stats. Flaming you for not being big enough, and therefore people should listen to me... Damned.
-In the case of glutamine i'm going to post studies proving it helps after surgery. I do absolutely not understand surgery differs from exercise, and state exercise is almost as catabolic as surgery.... When someone then posts studies showing glutamine does not work under normal stress, i completely overrule him by going offtopic again and claiming any of the previous points.

[IBdmfkr]

You still haven't answered the most important question of all. WHO is that in your avatar?

[Mesomorphyl]

Those are his silly friends LOL !

Can they bury their noses any further up his ass? I mean come on...

Yeah, show 'em big'r!

Big' r nice posts!!!

[big'r]

You still haven't answered the most important question of all. WHO is that in your avatar?

Ok then, i will tell you.
I'm from a european bb-board and this is the picture of a guy we owned on another forum. At some point of time there were 5 members with his avatar on our board.

Tallman is from my forum too. Everybody is ashamed of his gay-reactions on this board though. The name alone shows he's got to compensate for something

The superego boys are no clones of mine. They're board members. (Thanx to my brothers for the support)

[testosterona]

ooohhh your boyfriend? haha, fvck it dude, just drop it. meso and pinn are veterans on this board, your not gonna win anyways. haha

[Mesomorphyl]

Tallman is from my forum too. Everybody is ashamed of his gay-reactions on this board though.

The superego boys are no clones of mine. They're board members. (Thanx to my brothers for the support)

So because uncle olie and tallman did not support you, did not agree with you, or simply wanted you to finally post your source for the first post - MEMBERS OF YOUR BOARD THINK BAD OF THEM???

You are a sad peice of shiit. Your brothers you "thank" were only here as they are followers, they never contributed just kissed your ass.

[Pinnacle]

Don't sweat it Meso..we ruined any chance of him having credibilty on this board.
You need to change your location to "pissing on little'r"

~Pinnacle~

[big'r]

So because uncle olie and tallman did not support you, did not agree with you, or simply wanted you to finally post your source for the first post - MEMBERS OF YOUR BOARD THINK BAD OF THEM???

You are a sad peice of shiit. Your brothers you "thank" were only here as they are followers, they never contributed just kissed your ass.

Goddamned don't you guys have any ****ing sence of humor. I know everybody at my board laughs about this thread.

Tallman makes a joke about me, i joke about him. NOBODY AT MY BOARD THINKS BAD ABOUT ME, TALLMAN OR THE OTHER MEMBERS.

The other members just supported me as a joke on my board. Lighten up and don't take things so seriously.

FURTHERMORE: WHAT'S THE LACK OF RESPECT ON THIS BOARD?
WTF IS EVERYBODY FLAMING SOMEONE WHO CHALLENGES ANYBODY?

There is not 1 single board where people act so childish as here. Even when i explain my points and take up my part of the challenge.

[oswaldosalcedo]

men, we have to lower the rage.
peace

[Pinnacle]

FURTHERMORE: WHAT'S THE LACK OF RESPECT ON THIS BOARD?
WTF IS EVERYBODY FLAMING SOMEONE WHO CHALLENGES ANYBODY?

We are cocky,arrogant AMERICANS.We're hated by the world,so why should we disappoint?

GOD BLESS AMERICA


~Pinnacle~

[big'r]

men, we have to lower the rage.
peace

Glad someone can see things in perspective.

Respect!

[Mesomorphyl]

There is not 1 single board where people act so childish as here. Even when i explain my points and take up my part of the challenge.

First, we just asked for your source of information then you started acting childish... Half the reason you are not respected is you posted information and said you would back it up right away. Then only after we posted something... Did you need time?

The other board found it funny at your expense... oh, and my avatar

[big'r]

First, we just asked for your source of information then you started acting childish...

If you think a question of me backing up your claim glutamine works is childish, i'm glad to be a child!

Half the reason you are not respected is you posted information and said you would back it up right away. Then only after we posted something... Did you need time?

Right........ Quote me where i said that!!!!!!!

So when are you going to post the proof? I promise i will react by posting all studie backing up my claims.....
So bring it on. Or are you now going to state you actually can't find any positive study?

[Mesomorphyl]

If you think a question of me not backing up my claim glutamine doesn't do sh*t is childish, i'm glad to be a child!

Are you saying when I asked to see YOUR claims and you said "I will. Dont worry!!!" then not posting for 3 pages of banter is not childish? If you actually had the information you would have posted it. Yes you are a child and at least you are glad about it.

[TallMan]

Tallman is from my forum too. Everybody is ashamed of his gay-reactions on this board though. The name alone shows he's got to compensate for something

I'm just a tall man, 6,6ft to be exactly
and come on mister BIGr, the pot calls the kettle black !

again !

[RussianVodka]

FURTHERMORE: WHAT'S THE LACK OF RESPECT ON THIS BOARD?
WTF IS EVERYBODY FLAMING SOMEONE WHO CHALLENGES ANYBODY?

There is not 1 single board where people act so childish as here. Even when i explain my points and take up my part of the challenge.

Dude, your word means nothing for me and other people. You have seen a lot of studies about glutamine posted by respectable board members, but you are still posting some BS.

[topvega]

jesus christ... i haven't checked in on this thread since yesterday and all hell broke loose... i just spent 20 minutes of my life reading posts... and all of this was over fuking glutamine??? i would hate to see u talk religion or politics with pinn or messo...

[Mesomorphyl]

jesus christ... i haven't checked in on this thread since yesterday and all hell broke loose... i just spent 20 minutes of my life reading posts... and all of this was over fuking glutamine??? i would hate to see u talk religion or politics with pinn or messo...

HAHA

Stop by the political forum, lol.

Listen, it was not all about glutamine... It was this guy said it don't do sh*t... Alot of people must be wrong. This guy big'r also claims that you should use(as he does) dextrose prior to working out including cardio... How can anyone take him seriously? I will not. Even with all his studies.

[big'r]

I'm just a tall man, 6,6ft to be exactly
and come on mister BIGr, the pot calls the kettle black !

again !

Heb ik je naam toch verkeerd geinterpreteerd,
Maakt nie uit hoor kerel. Dit stelletje zut is te triest voor woorden.

Ownen is gewoon grappig!!

De smilies kunnen er hier wel mee door, niet?

[big'r]

HAHA

Stop by the political forum, lol.

Listen, it was not all about glutamine... It was this guy said it don't do sh*t... Alot of people must be wrong. This guy big'r also claims that you should use(as he does) dextrose prior to working out including cardio... How can anyone take him seriously? I will not. Even with all his studies.

NO WAY.... This must be bullshit right. Big'r could not be smarter than me, could he?


Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise
Kevin D. Tipton1,2, Blake B. Rasmussen1,2, Sharon L. Miller1,2, Steven E. Wolf1, Sharla K. Owens-Stovall1, Bart E. Petrini1, and Robert R. Wolfe1,2

1 Department of Surgery, University of Texas Medical Branch, and 2 Metabolism Unit, Shriners Hospitals for Children, Galveston, Texas 77550

The present study was designed to determine whether consumption of an oral essential amino acid-carbohydrate supplement (EAC) before exercise results in a greater anabolic response than supplementation after resistance exercise. Six healthy human subjects participated in two trials in random order, PRE (EAC consumed immediately before exercise), and POST (EAC consumed immediately after exercise). A primed, continuous infusion of L-[ring-2H5]phenylalanine, femoral arteriovenous catheterization, and muscle biopsies from the vastus lateralis were used to determine phenylalanine concentrations, enrichments, and net uptake across the leg. Blood and muscle phenylalanine concentrations were increased by ~130% after drink consumption in both trials. Amino acid delivery to the leg was increased during exercise and remained elevated for the 2 h after exercise in both trials. Delivery of amino acids (amino acid concentration times blood flow) was significantly greater in PRE than in POST during the exercise bout and in the 1st h after exercise (P < 0.05). Total net phenylalanine uptake across the leg was greater (P = 0.0002) during PRE (209 ± 42 mg) than during POST (81 ± 19). Phenylalanine disappearance rate, an indicator of muscle protein synthesis from blood amino acids, increased after EAC consumption in both trials. These results indicate that the response of net muscle protein synthesis to consumption of an EAC solution immediately before resistance exercise is greater than that when the solution is consumed after exercise, primarily because of an increase in muscle protein synthesis as a result of increased delivery of amino acids to the leg.

[bigbouncinballs]

We are cocky,arrogant AMERICANS.We're hated by the world,so why should we disappoint?

GOD BLESS AMERICA


~Pinnacle~

werd!

[IBdmfkr]

And who the f uck ar u? some ectomorph? or are u meso and pinn's lapdog, sucking their dicks every night u go to bed?

Why are you and your gay gang even here? It's not to contribute anything obviously. Take Sideshow and go back to forum you came from. Or post up the link to your forum so we can all come talk shit and waste space on your board.

[Pinnacle]

YEAHHHHAAAAA howdy, im a bloody yankee from the south balablablabladieblabaldiebla

lol this cracks me up, ur so funny

I know..I saw it posted on your board!!!


I have more respect than that.I could easily sign up to your board,along with MANY others,and shit all over the board.

http://www.dutchbodybuilding.com/fo...ead.php?t=47109


Us Americans might be hated world wide,But we aren't PUNKS like YOU and YOUR ass buddies.

See ya round little fellow!!!

[IBdmfkr]

whooeoeoeoheoheoehoehoeheoehoe what ar u saying I can't understand U?

That does not suprise me. I wouldn't think you would be intelligent enough to respond with a better excuse than that.

[Pinnacle]

RElax thake a chill pill dude, what u mean by punks?? and what's up with the asses of my buddies? (hmm normally i would flame about ur sexual preferences,but ey im in a good mood)

Your AMERICAN and don't understand AMERICAN slang?


You don't know what the word PUNK means either?



Flame a slang?


Like I said previously see ya round PUNK!!!!!!!

[Mesomorphyl]

lol sure i know what punk means dipshit !!(this word just suited the situation)
flame like in ...

You are lashing out... yet you are still senseless. You did not understand the word punk and it is obvious. Then you say flame like in... And still did not explain yourself. Your posts all have been nothing but a heaping pile of cow dung licking the testicles of your gay lover big'r.

[IBdmfkr]

Jezurd
Why do you type like your mentally handicapped a few threads up and then you type like your from the streets in america in the next thread down. Is Big'r sitting on your lap and helping you type your posts? You two fags discust me.

Did you understand that you PUNK?

[TallMan]

Heb ik je naam toch verkeerd geinterpreteerd,
Maakt nie uit hoor kerel. Dit stelletje zut is te triest voor woorden.

Ownen is gewoon grappig!!

De smilies kunnen er hier wel mee door, niet?

idd ik zit trouwens maar beetje te fokken...

Je had het wat anders moeten aanpakken, wat zachter moeten brengen
inplaats van zo uitdagend.
Maar hun hadden ook niet zo geflipt hoeven reageren natuurlijk.

And now go on with the flame-wars