01-10-2006, 06:15 PM #1
whats best to use comming off a test cycle
I'm running test E 500mg 12 weeks with 4 week kickstart of dbol and was pondering what the best substance to use comming off. At first I thought winni but I'll save that for a cutter and then I thought of Tbol but I dunno about 2 17aa's rough on the liver. I saw a thread earlier about running prop for the last 6 weeks or so but I'm not too sure. Any input?
01-10-2006, 07:07 PM #2
prop is good for the last weeks of your cycle, tends to harden them. as far as having two 17aa's its ok if u do d bol at the beginning and take a break and then do t bol at the end. some people actually reccomend to do some orals right before coming off....just make sure when taking 17aa's u give ur liver time to recooperate...
01-10-2006, 07:15 PM #3Originally Posted by Got Insulin?
01-10-2006, 07:17 PM #4
do that and ur set..try to keep at least 4 weeks in between ... other then that ur set
01-10-2006, 09:50 PM #5Originally Posted by Got Insulin?
01-10-2006, 09:57 PM #6supersteve Guest
It is interesting to note that some 17-aa orals increase glucocorticoid receptor density.
Probably not the best thing right before you start PCT when cortisone will be very high.
Would be best to run the test a week past a 17-aa oral.
Unfortunately tbol wasn't tested in the study. Possibly fair to assume it would cause the same problem though.
[3H]dexamethasone binding activity in liver microsomes is modulated differently by 17 alpha-alkylated androgens and testosterone in vivo.
Rat liver microsomes contain a single class of steroid binding sites, capable of binding various glucocorticoids and progesterone. In a previous article, we have described the in vitro interaction of several androgens with this binding site. Unlike natural androgens, the 17 alpha-alkyl derivatives stanozolol and danazol were capable of interacting with this binding site through a negative allosteric pattern. Now, the effects these steroids exert on the microsomal [3H]dexamethasone binding site have been studied in vivo. The administration of a single dose of stanozolol to rats provoked a significant reduction in the microsomal [3H]dexamethasone binding capacity. This effect was maximal two hr after stanozolol administration and persisted for six hr. The restoration of the [3H]dexamethasone binding level after stanozolol administration was dependent on protein synthesis, since it was blocked by the concomitant administration of cycloheximide. None of the other androgens tested (danazol, methyltestosterone , fluoxymesterone, and testosterone propionate ) was capable of provoking a similar effect when administered 2 or 24 hr prior to sacrifice. In rats treated for seven days with a daily dose of diverse androgens and sacrificed 24 hr after the last treatment, none of the 17 alpha-alkyl androgens assayed provoked significant changes in the microsomal [3H]dexamethasone binding level, although stanozolol, danazol, and methyltestosterone provoked a significant increase in glucocorticoid receptor concentration. In contrast, the administration of testosterone propionate provoked a 50% reduction in the [3H]dexamethasone binding level without causing changes in the glucocorticoid receptor concentration. These results provide new evidence on the existence of different effects on the liver of 17 alpha-alkyl androgens, compared to the effects produced by natural androgens.
Last edited by supersteve; 01-10-2006 at 10:03 PM.
01-10-2006, 10:10 PM #7Originally Posted by supersteve
01-10-2006, 10:28 PM #8
antone else I'm still pretty curious
01-10-2006, 10:38 PM #9
You could end with 2 weeks of prop then jump into PCT 3 days following
01-11-2006, 09:25 AM #10Originally Posted by chest6
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