Major Adverse Drug Reactions when using Testosterone Enanthate
Ok, well I see every so often, that a member posts a thread asking "Will taking Testosterone E or C interact with medication X that I take for condition Y." So, i will include in this thread the MAJOR drug interactions when taking Testosterone Enanthate or Cypionate. There are 235 Moderate reactions, but for now I will only post the severe/major ones.
Godfather
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The following drugs which are heart medications, have the following potential ADR with Testosterone treatment
Anisindione
Coumadin
Dicumarol
Jantoven
Miradon
Warfarin
MONITOR CLOSELY: Androgens and anabolic steroids may potentiate the hypoprothrombinemic response to oral anticoagulants and increase the risk of bleeding. The onset of interaction is generally observed within 2 to 3 days. The mechanism is unknown. There have been case reports of patients stabilized on oral anticoagulant therapy who developed bleeding complications following the addition of various androgenic agents including danazol, oxymetholone, testosterone, methyltestosterone, and stanozolol. In a clinical study (n=15), the concomitant administration of oxandrolone 10 to 20 mg per day increased the half-life of the more active S(-) enantiomer of warfarin from 26 to 48 hours and the systemic exposure (AUC) from 4.55 to 12.08 ng-hr/mL. R(-) warfarin half-life and AUC also increased. Microscopic hematuria and gingival bleeding were reported, and the warfarin dose had to be reduced by 80% to 85% to maintain the desired INR.
MANAGEMENT: During concomitant therapy, the INR and/or PT should be monitored closely and anticoagulant dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of the androgenic agent in patients who are stabilized on their anticoagulation regimen. Significant anticoagulant dose reductions may be required. Some experts recommend avoiding this combination altogether. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
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Drugs Listed as having a MODERATE interaction-
acetoHEXAMIDE, Agenerase, Amaryl, amprenavir, Apidra, Apidra OptiClik Cartridge, aprepitant, Arava, Armour Thyroid, Avonex, Avonex Prefilled Syringe, Betaseron, bosentan, Cardizem, Cardizem CD, Cardizem LA, Cardizem Monovial, Cardizem SR, Cartia XT, chlorproPAMIDE, clofarabine, Clolar, conivaptan, cycloSPORINE, Cytomel, dalfopristin, dasatinib, DiaBeta, Diabinese, D***ucan, Dilacor XR, Diltia XT, diltiazem, diltiazem 24 hour extended release, diltiazem extended release, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, Dymelor, echinacea, efavirenz, Eltroxin, Emend, Emend 3-Day, Euthyrox, Eutroxsig, Evotrox, EXUBERA, EXUBERA Combination Pack 12, EXUBERA Combination Pack 15, EXUBERA Kit, FK506, fluconazole, fluvoxamine, Folex PFS, Fortovase, fosamprenavir, Gengraf, Gleevec, glimepiride, glipiZIDE, glipiZIDE extended release, GlipiZIDE XL, Glucotrol, Glucotrol XL, glyBURIDE, glyBURIDE micronized, Glynase PresTab, grepafloxacin, Humalog, Humalog Pen, Humulin L, Humulin N, Humulin N Pen, Humulin R, Humulin R (Concentrated), Humulin U, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin Lente, Iletin NPH, Iletin Regular, imatinib, insulin, insulin analog, insulin aspart, insulin aspart protamine, insulin detemir, insulin glargine, insulin glulisine, insulin inhalation, rapid acting, insulin isophane, Insulin Lente Pork, insulin lispro, insulin lispro protamine, Insulin Purified NPH Pork, Insulin Purified Regular Pork, insulin regular, insulin zinc, insulin zinc extended, insulin, lente, insulin, NPH, insulin, ultralente, interferon beta-1a, interferon beta-1b, Invirase, itraconazole, Ketek, Ketek Pak, L THYROXINE ROCHE, l-thyroxine, Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen, lapatinib, leflunomide, Lente insulin, Levemir, Levemir FlexPen, Levemir InnoLet, Levemir PenFill, Levo-T, Levotabs, Levotec, Levothroid, LEVOTHYROX, levothyroxine, Levoxyl, Lexiva, liothyronine, liotrix, Luvox, methotrexate, mibefradil, Micronase, Mifeprex, mifepristone, naltrexone, nateglinide, Nature-Throid, nefazodone, nelfinavir, Neoral, Norvir, Norvir Soft Gelatin, Novolin L, Novolin N, Novolin N Innolet, Novolin N PenFill, Novolin R, Novolin R Innolet, Novolin R PenFill, NovoLog, NovoLog FlexPen, NovoLog PenFill, Noxafil, NPH insulin, Orinase, Oroxine, oxcarbazepine, posaconazole, Posicor, Prandin, Priftin, Prograf, protamine zinc insulin, Rapamune, Raxar, Rebif, regular insulin, repaglinide, ReVia, Rezulin, Rheumatrex Dose Pack, rifapentine, ritonavir, RU-486, Sandimmune, saquinavir, saquinavir mesylate, Serzone, sirolimus, Sporanox, Sprycel, Starlix, Sustiva, Synthroid, tacrolimus, Taztia XT, telithromycin, Telzir, thioguanine, thyroid desiccated, Thyrolar-1, Thyrolar-1/2, Thyrolar-1/4, Thyrolar-2, Thyrolar-3, Tiazac, Tirosint, Tol-Tab, TOLAZamide, TOLBUTamide, Tolinase, Tracleer, Trexall, Trileptal, Triostat, troglitazone, Tykerb, Ultralente insulin, Unithroid, Vaprisol, Velosulin BR, VFEND, Viracept, Vivitrol, voriconazole, Westhroid.
Major Adverse Drug Reaction from administration of Winstrol (Stanozolol)
The following drugs will have a major interaction with Stanozolol(Winstrol).
Anisindione
Coumadin
Dicumarol
Jantoven
Miradon
Warfarin
MONITOR CLOSELY: Androgens and anabolic steroids may potentiate the hypoprothrombinemic response to oral anticoagulants and increase the risk of bleeding. The onset of interaction is generally observed within 2 to 3 days. The mechanism is unknown. There have been case reports of patients stabilized on oral anticoagulant therapy who developed bleeding complications following the addition of various androgenic agents including danazol, oxymetholone, testosterone, methyltestosterone, and stanozolol. In a clinical study (n=15), the concomitant administration of oxandrolone 10 to 20 mg per day increased the half-life of the more active S(-) enantiomer of warfarin from 26 to 48 hours and the systemic exposure (AUC) from 4.55 to 12.08 ng-hr/mL. R(-) warfarin half-life and AUC also increased. Microscopic hematuria and gingival bleeding were reported, and the warfarin dose had to be reduced by 80% to 85% to maintain the desired INR.
MANAGEMENT: During concomitant therapy, the INR and/or PT should be monitored closely and anticoagulant dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of the androgenic agent in patients who are stabilized on their anticoagulation regimen. Significant anticoagulant dose reductions may be required. Some experts recommend avoiding this combination altogether. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
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The following drugs are listed as having a MODERATE reaction to Stanozolol
acetoHEXAMIDE, Amaryl, Apidra, Apidra OptiClik Cartridge, Arava, Armour Thyroid, Avonex, Avonex Prefilled Syringe, Betaseron, chlorproPAMIDE, clofarabine, Clolar, cycloSPORINE, Cytomel, DiaBeta, Diabinese, Dymelor, echinacea, Eltroxin, Euthyrox, Eutroxsig, Evotrox, EXUBERA, EXUBERA Combination Pack 12, EXUBERA Combination Pack 15, EXUBERA Kit, Folex PFS, Gengraf, glimepiride, glipiZIDE, glipiZIDE extended release, GlipiZIDE XL, Glucotrol, Glucotrol XL, glyBURIDE, glyBURIDE micronized, Glynase PresTab, Humalog, Humalog Pen, Humulin L, Humulin N, Humulin N Pen, Humulin R, Humulin R (Concentrated), Humulin U, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin Lente, Iletin NPH, Iletin Regular, insulin, insulin analog, insulin aspart, insulin aspart protamine, insulin detemir, insulin glargine, insulin glulisine, insulin inhalation, rapid acting, insulin isophane, Insulin Lente Pork, insulin lispro, insulin lispro protamine, Insulin Purified NPH Pork, Insulin Purified Regular Pork, insulin regular, insulin zinc, insulin zinc extended, insulin, lente, insulin, NPH, insulin, ultralente, interferon beta-1a, interferon beta-1b, L THYROXINE ROCHE, l-thyroxine, Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen, leflunomide, Lente insulin, Levemir, Levemir FlexPen, Levemir InnoLet, Levemir PenFill, Levo-T, Levotabs, Levotec, Levothroid, LEVOTHYROX, levothyroxine, Levoxyl, liothyronine, liotrix, methotrexate, Micronase, naltrexone, nateglinide, Nature-Throid, Neoral, Novolin L, Novolin N, Novolin N Innolet, Novolin N PenFill, Novolin R, Novolin R Innolet, Novolin R PenFill, NovoLog, NovoLog FlexPen, NovoLog PenFill, NPH insulin, Orinase, Oroxine, Prandin, protamine zinc insulin, Rebif, regular insulin, repaglinide, ReVia, Rheumatrex Dose Pack, Sandimmune, Starlix, Synthroid, thioguanine, thyroid desiccated, Thyrolar-1, Thyrolar-1/2, Thyrolar-1/4, Thyrolar-2, Thyrolar-3, Tirosint, Tol-Tab, TOLAZamide, TOLBUTamide, Tolinase, Trexall, Triostat, Ultralente insulin, Unithroid, Velosulin BR, Vivitrol, Westhroid,
Adverse Drug Reactions with the administration of INSULIN
There are the following adverse drug reactions when using INSULIN.
Gat***oxacin
Tequin
Tequin
Teqpaq
CONTRAINDICATED: Gat***oxacin may interfere with the therapeutic effects of oral antidiabetic agents and insulin. The use of various quinolones has been associated with disturbances in blood glucose homeostasis possibly stemming from effects on pancreatic beta cell ATP-sensitive potassium channels that regulate insulin secretion. However, hypoglycemia and hyperglycemia have been reported more frequently with gat***oxacin than with other quinolones. Gat***oxacin-induced hypoglycemic episodes have generally occurred within the first 3 days of therapy and sometimes even after the first dose, while hyperglycemia usually occurred 4 to 10 days after initiation of therapy. Death has been reported in severe cases. Coadministration of gat***oxacin with sulfonylureas (most often glyburide) and/or other oral hypoglycemic agents has resulted in severe, refractory hypoglycemia and hypoglycemic coma. Elderly patients and patients with reduced renal function are particularly susceptible.
MANAGEMENT: The use of gat***oxacin is contraindicated in patients with diabetes mellitus. Other quinolones may be safer alternatives in such patients, although all quinolones should be used with caution. Blood glucose should be monitored closely whenever quinolones are prescribed to patients receiving oral antidiabetic agents and/or insulin, especially if they are elderly or have renal impairment. Patients should be counseled to recognize symptoms of hypoglycemia such as headache, dizziness, drowsiness, nausea, tremor, weakness, hunger, excessive perspiration, and palpitations. If hypo- or hyperglycemia occur during quinolone therapy, patients should initiate appropriate remedial therapy immediately, discontinue the antibiotic, and contact their physician.
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MODERATE adverse drug reactions with the administration of Insulin.
A-Hydrocort, A-Methapred, Abilify, Abilify Discmelt, Accuneb, Accupril, acebutolol, Aceon, acetaZOLAMIDE, acetaZOLAMIDE extended release, Acetocot, Acetylsalicylic Acid, ACTH, ACTH Gel, ACTH-40 HP, ACTH-80, Acthar, Acthar Gel, H.P., Acthrel, Actos, Acuprin 81, Acutrim 16 Hour, Acutrim II, Maximum Strength, Acutrim Late Day, Adbeon, Adgan, Adgyn Estro, Adlone-40, Adlone-80, Adoxa, Adrenalin, Adrenocot, Adrenocot L.A., Aerodiol, Afrinol, Agenerase, Ah-Chew D, Airet, Akbeta, Ala-Tet, alatrofloxacin, albuterol, albuterol extended release, alcohol, alcohol, ethyl, Alodox, aloe vera, Alora, Altace, Alupent, Amen, Amigesic, amprenavir, Ana-Guard, Anabolin LA, Anadrol-50, Anaflex, Andro LA 200, Andro-Cyp 100, Andro-Cyp 200, Androderm, AndroGel, AndroGel 1.25 g/actuation, AndroGel 2.5 g/packet, AndroGel 5 g/packet, Android, Android-10, Android-25, Androlone-D, Andryl 200, Anergan 50, Antara, Antinaus 50, Aptivus, Aquacot, Aquatensen, Aquazide H, Aquest, Aramine, arformoterol, Argesic-SA, aripiprazole, Aristocort, Aristocort For Injection, Aristocort Forte, Aristopak, Aristospan Injection, Armour Thyroid, Arthritis Pain, Arthropan, ASA, Ascriptin Enteric, asparaginase, Aspergum Cherry, Aspergum Orginal, Aspir-Low, aspirin, aspirin extended release, Aspirin Lite Coat, Aspirin Litecoat, Aspirin Low Strength, Aspirtab, Asthmahaler, Asthmanefrin, Atapryl, atazanavir, atenolol, Atromid-S, Avandia, Avelox, Avelox I.V., Aygestin, Azilect, Azmacort, Azulfidine, Azulfidine EN-tabs, B-3-50, B3-500-Gr, Bayer Aspirin, Bayer Aspirin Regimen, Bayer Aspirin with Calcium, Bayer Childrens Aspirin, Bayer Low Strength, Bayer Plus, Bayer Select Backache Pain Formula, Bedol, benazepril, bendroflumethiazide, benzthiazide, Beta-Phos/AC, Betagan, Betagan C-Cap, betamethasone, betamethasone acet-betamethasone na phosphate, betamethasone sodium phosphate, Betapace, Betapace AF, Betapace AF(obsolete), betaxolol, betaxolol ophthalmic, Betimol, Betoptic, Betoptic S, Bismarex, Bismatrol, bismuth subsalicylate, bisoprolol, Blocadren, Brethaire, Brethine, Brevibloc, Bricanyl, Brodspec, Bronchial Mist with Pump, Bronitin, Bronkaid Mist, Brovana, Bubbli-Pred, Buffered Aspirin, Bufferin, Bufferin Arthritis Strength, Bufferin Extra Strength, Buffex, bumetanide, Bumex, Camila, Capoten, captopril, Carbex, Cardioquin, Carozide, carteolol, carteolol ophthalmic, Cartrol, carvedilol, carvedilol extended release, Catapres, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3, Celestone, Celestone Phosphate, Celestone Soluspan, Celexa, Cell-U-Jec, Cenafed, Cenestin, Cerebyx, Childrens Kaopectate, Chlor Trimeton Nasal Decongestant, chlorothiazide, chlorotrianisene, chlorproMAZINE, chlorproMAZINE extended release, chlorthalidone, choline salicylate, Chroma-Pak, chromic chloride, chromic chloride hexahydrate, Chromium GTF, chromium picolinate, Cinobac, cinoxacin, Cipro, Cipro Cystitis Pack, Cipro I.V., Cipro XR, ciprofloxacin, ciprofloxacin extended release, citalopram, Climara, Climaval, Climodien, Clinacort, Clinagen LA 40, Clinalog, clofibrate, clonidine, clonidine topical, Clopine, clozapine, Clozapine Synthon, Clozaril, Colocort, Compazine, Compazine Spansule, Compro, conjugated estrogens, conjugated estrogens synthetic A, conjugated estrogens synthetic B, conjugated estrogens topical, Contac 12-Hour, Contac Cold, Control, Coreg, Coreg CR, Corgard, Cort-K, Cortastat, Cortastat 10, Cortastat LA, Cortef, Cortenema, corticorelin, corticotropin, Cortifoam, cortisone, Cortone Acetate, Cortrosyn, cosyntropin, Cotolone, Cr-GTF, Crinone, Crixivan, CRM, Curretab, Cyclogest, Cycrin, Cytomel, Dalalone, Dalalone D.P., Dalalone L.A., danazol, Danocrine, Daranide, darunavir, Darvon, Darvon-N, De-Sone LA, Deca-Durabolin, Decadron, Decadron 5-12 Pak, Decadron Phosphate, Injectable, Decadron-LA, Decaject, Decaject L.A., Declomycin, Decofed, Decofed Liquid, Dehydrated Alcohol, Delatest, Delatestryl, Delestrogen, DELIDOSE, Delta-Lutin, Deltasone, Demadex, Demadex I.V., demeclocycline, Denzapine, Dep Gynogen, Dep Medalone 80, Depandro 100, Depmedalone, Depo-Estradiol, Depo-Medrol, Depo-Predate (obsolete), Depo-Provera, Depo-Provera Contraceptive, depo-subQ provera 104, Depo-Testosterone, Depogen, Depoject-80, Depopred, Depotest, Dermestril, Dermestril - Septem, DERMESTRIL SEPTEM, deserpidine, desogestrel, Despec-SF, Dexacen-4, Dexacort Phosphate in Respihaler, Dexacort-LA, Dexacorten, dexamethasone, dexamethasone acetate, Dexamethasone Intensol, dexamethasone sodium phosphate, Dexasone, Dexasone LA, Dexatrim, Dexatrim Caffeine Free, Dexone, Dexone LA, Dexpak Jr. Taperpak, Dexpak Taperpak, Di-Phen, Diamox, Diamox Sequels, Diaqua, Diaqua-2, diazoxide, dichlorphenamide, dienestrol topical, diethylstilbestrol, d***unisal, Dilantin, Dilantin Infatabs, Dilantin Kapseals, Dilantin-125, Dimetapp 12-Hour Non-Drowsy Extentabs, Dimetapp Children's Cold & Allergy, Dimetapp Cold Drops, Dimetapp Decongestant, Dimetapp Infant Drops, Dioval 40, Dioval XX, Disalcid, disopyramide, disopyramide extended release, Diucardin, Diurese, Diuril, Diuril Sodium, Divigel 0.25 mg/packet, Divigel 0.5 mg/packet, Divigel 1 mg/packet, Doans Pills, Doans Pills Extra Strength, DOBUTamine, Dobutrex, Dolobid, Dom-Fenofibrate, DOPamine, Doryx, Doxy Lemmon, Doxy-Caps, Doxy-D, doxycycline, doxycycline hyclate, doxycycline monohydrate, Drixoral Decongestant Non-Drowsy, Drixoral Non-Drowsy, drospirenone, Dura-Estrin, Durabolin, Durabolin 50, Duraclon, Duragen, Duralone, Duralutin, Duratest, Durathate 200, Dynacin, Easprin, Ecotrin, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Edecrin, Edecrin Sodium, Efidac, Eldepryl, Elestrin, Elixsure Decongestant, Elleste Solo, Elspar, Eltroxin, Emcyt, Empirin, Empro, Emsam, Emtet-500, enalapril, enalaprilat, Endometrin, Enduron, Enjuvia, enoxacin, Entaprin, Entercote, ephedra, ephedrine, Epi EZ Pen, epinephrine, EpiPen 2-Pak, EpiPen Auto-Injector, EpiPen JR 2-Pak, EpiPen JR Auto-Injector, Errin, escitalopram, Esclim, Esidrix, Eskalith, Eskalith-CR, esmolol, esterified estrogens, Estinyl, Estra-C, Estra-V 40, Estrace, Estrace Vaginal Cream, Estraderm, Estraderm MX, Estraderm TTS, estradiol, estradiol acetate, estradiol benzoate, estradiol cypionate, ESTRADIOL G GAM, Estradiol Patch, estradiol topical, estradiol valerate, Estradot, Estradot 100, Estradot 37.5, Estradot 50, Estradot 75, Estragyn 5, Estragyn LA 5, estramustine, ESTRAPATCH, Estrasorb, ESTREVA, Estring, Estro-A, Estro-Cyp, Estro-L.A., Estro-Span 40, Estrofem, Estrogel, estrone, Estrone AQ, estropipate, estropipate topical, ethacrynic acid, ethanol, ethinyl estradiol, Ethyl Alcohol, ethynodiol, etonogestrel, Euthyrox, Eutroxsig, Everone, Evorel, Evotrox, Exna, Extra Strength Bayer, Ezide, Factive, FazaClo, Fematrix, Fempatch, Femring, FEMSEPT, FemSeven, FemSeven Sequi Phase I, FemTab, Femtrace, Femtran, fenfluramine, fenofibrate, First Progesterone MC10, First Progesterone MC5, First Testosterone, FIRST-Progesterone VGS 100, FIRST-Progesterone VGS 200, FIRST-Progesterone VGS 25, FIRST-Progesterone VGS 400, FIRST-Progesterone VGS 50, FIRST-Testosterone, FIRST-Testosterone MC, Florinef Acetate, Floxin, Floxin I.V., fludeoxyglucose F18, fludrocortisone, fluoxetine, fluoxetine extended release, fluoxymesterone, fluphenazine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine hydrochloride, fluvoxamine, Fortamet, Fortovase, fosamprenavir, fosinopril, fosphenytoin, furosemide, Gantanol, Gantrisin, Gantrisin Pediatric, gemfibrozil, gem***oxacin, Genacote, Genaphed, Gennin-FC, Genotropin, Genotropin Miniquick, Genprin, Geodon, Gestone, Glauctabs, Glucophage, Glucophage XR, Glumetza, grepafloxacin, guanadrel, guanethidine, Gynodiol, Gynogen LA 20, Halfprin, Halotestin, Harmonyl, HCTZ, Hexadrol, Hexadrol Phosphate, Histerone, Humatrope, Hybolin Decanoate, Hybolin-Improved, Hydeltra-T.B.A., Hydeltrasol, Hydro Par, hydrochlorothiazide, hydrocortisone, hydrocortisone acetate, hydrocortisone cypionate, hydrocortisone hemisuccinate, hydrocortisone sodium phosphate, Hydrocortisone Sodium Succinate, Hydrocortone, Hydrocortone Phosphate, HydroDIURIL, hydroflumethiazide, hydroxyprogesterone, Hygroton, Hylorel, Hylutin, Hyperstat, Hyprogesterone, Implanon, Increlex, indapamide, Inderal, Inderal LA, indinavir, INH, InnoPran XL, Intropin, Invega, Invirase, iPlex, Ismelin, isocarboxazid, isoniazid, isoproterenol, Istalol, Isuprel HCl, Isuprel Mistometer, Jolivette, Jumex, K-Pek, Kao-Tin Bismuth Subsalicylate Formula, Kaopectate, Kaopectate Anti-Diarrheal Upset Stomach Reliever, Kaopectate Extra Strength, Kapectolin (New Formula), Ken-Jec 40, Kenaject-40, Kenalog-10, Kenalog-40, Kerlone, Kestrone 5, Key-Pred, Key-Pred SP, Kid Kare Drops, L THYROXINE ROCHE, l-thyroxine, labetalol, Largon, Lasix, Levaquin, Levaquin Leva-Pak, Levatol, Levo-T, levobetaxolol ophthalmic, Levobunolol, levobunolol ophthalmic, levofloxacin, levonorgestrel, Levophed Bitartrate, Levoprome, Levotabs, Levotec, Levothroid, LEVOTHYROX, levothyroxine, Levoxyl, Lexapro, Lexiva, liothyronine, liotrix, Lipidil EZ, Lipidil Micro, Lipidil Supra, Lipofen, Liquid Pred, lisinopril, Litecoat Aspirin, lithium, lithium carbonate, lithium carbonate extended release, lithium citrate, Lithobid, Lithonate, Lithotabs, Lo-Aqua, Lofibra, lomefloxacin, Lopid, lopinavir, Lopressor, Loqua, Lotensin, Low Dose ASA, Lozol, Lusonal, Luvox, M-Prednisolone, ma huang, Maalox Total Stomach Relief, Magan, magnesium salicylate, Marplan, Marthritic, Mavik, Maxaquin, Maximum Strength Stress, mecasermin, mecasermin rinfabate, Med-Jec-40, Medicort, Medidex, Medidex LA, Medidiol 10, Medihaler-Epi, Medihaler-Iso, Medipred, Meditest, Medralone, Medralone 40, Medralone 80, Medrol, Medrol Dosepak, medroxyPROGESTERone, Mega-Trim, Megace, Megace ES, megestrol, Mellaril, Mellaril-S, Menaval-20, Menest, MENOREST, Menorest Patch, Menostar, mephentermine, ****ridazine, mestranol, Meta Trace FDG, Metahydrin, Metaprel, metaproterenol, metaraminol, metformin, metformin extended release, Methacort 40, Methacort 80, methazolamide, methdilazine, Methitest, methotrimeprazine, methoxamine, methyclothiazide, Methylcotol, Methylcotolone, Methylpred DP, methylPREDNISolone, methylPREDNISolone acetate, MethylPREDNISolone Dose Pack, methylPREDNISolone sodium succinate, methylTESTOSTERone, Meticorten, metipranolol ophthalmic, metolazone, metoprolol, metoprolol extended release, metoprolol succinate, metoprolol tartrate, Micronefrin, Microzide, Minitabs, Minocin, Minocin PAC, minocycline, minocycline extended release, Mirena, Mobidin, moexipril, Mono-Gesic, Monodox, Monopril, mox***oxacin, MST, Myfedrine, Mykrox, Myrac, MZM, nadolol, nalidixic acid, nandrolone, nandrolone decanoate, nandrolone phenpropionate, Naqua, Nardil, Nasop, Nasop12, Nature-Throid, Naturetin-10, Naturetin-5, Nebupent, Neggram, nelfinavir, Neo-Synephrine, Nephron, Neptazane, niacin, niacin extended release, Niacin SR, Niacinamide, Niacor, Niacor B3, Niaspan ER, Niaspan ER Starter Pack, Nico-400, Nicobid Tempules, Nicolar, nicotinamide, Nicotinex, Nicotinic Acid, Nor-QD, Nora-Be, Norditropin, Norditropin Cartridge, Norditropin Nord***ex Pen, norepinephrine, norethindrone, norethindrone acetate, norethindrone topical, norfloxacin, norgestimate, norgestrel, Normodyne, Noroxin, Norpace, Norpace CR, Norplant System, Norvir, Norvir Soft Gelatin, Norwich Aspirin, Nuprin Backache Caplet, Nutropin, Nutropin AQ, Nutropin Depot, Nuvelle TS Phase I, Nydrazid, octreotide, Ocupress, Oesclim, Oestradiol, Oestradiol Implants, OESTRODOSE, OESTROGEL, Oestrogel Pump-Pack, ofloxacin, Ogen 0.625, Ogen 1.25, Ogen 2.5, Ogen Vaginal Cream, olanzapine, Omnitrope, Oncaspar, OptiPranolol, Oracea, Orapred, Orapred ODT, Orasone, Oretic, Oreton Methyl, Organon Oestradiol, Orion Progesterone, Ormazine, OROMONE, Oroxine, Ortho Dienestrol, Ortho Micronor, Ortho-Est, Ovrette, Oxandrin, oxandrolone, oxymetholone, oxytetracycline, paliperidone, Panmycin, Parnate, paroxetine, paroxetine extended release, paroxetine mesylate, Paxil, Paxil CR, Pediacare Drops, Pediapred, pegaspargase, pegvisomant, penbutolol, Penetrex, Pentam 300, pentamidine, Pentazine, Peptic Relief, Pepto-Bismol, Pepto-Bismol Maximum Strength, perindopril, Periostat, Permitil, perphenazine, Pexeva, Phenadoz, Phenazine 50, phenelzine, Phenergan, Phenergan Fortis, Phenoject-50, phenyl salicylate, Phenyldrine, phenylephrine, phenylephrine extended release, phenylpropanolamine, Phenytek, phenytoin, phenytoin extended release, Phenytoin Sodium, Prompt, pindolol, Pink Bismuth, pioglitazone, Plan B, polythiazide, Pondimin, PP-Cap, Pred-Ject-50, Predacort 50, Predacorten, Predaject-50, Predalone 50, Predate-50, Predcor, Predicort RP, Predicort-50, Prednicen-M, Prednicot, prednisoLONE, prednisoLONE acetate, prednisoLONE sodium phosphate, prednisoLONE tebutate, predniSONE, Prelone, Premarin, Premarin Intravenous, Premarin Vaginal, Prezista, Pri-Cortin 50, Primatene Mist Inhaler, Primatene Mist Suspension, Primethasone, Primogyn Depot, Prinivil, Pro-Med, ProAir HFA, Prochieve, prochlorperazine, prochlorperazine extended release, Procot, Prodrox, Progest, Progestasert System, progesterone, progesterone topical, Proglycem, Progynova, Progynova TS, Prolixin, Prolixin Decanoate, Prolixin Enanthate, Promacot, promazine, promethazine, Promethegan, Prometrium, Propagest, Propan, propiomazine, propoxyphene, propoxyphene hydrochloride, propoxyphene napsylate, propranolol, propranolol extended release, Proquin XR, Prorex, Protropin, PROVAMES, Proventil, Proventil HFA, Proventil Repetabs, Provera, Prozac, Prozac Weekly, pseudoephedrine, pseudoephedrine extended release, QM-260, Qualaquin, quetiapine, quetiapine extended release, Quin-G, Quin-Release, Quinaglute Dura-Tabs, quinapril, quinestrol, Quinidex Extentabs, quinidine, quinidine extended release, quinine, Quinora, racepinephrine, ramipril, Rap***ux, rasagiline, Rauwolfemms, Rauwolfia 1X, rauwolfia serpentina, Raxar, Renese, reserpine, Respirol, Rexolate, Reyataz, Rezulin, Rhindecon, Ridafed, Riomet, Risperdal, Risperdal Consta, Risperdal M-Tab, risperidone, ritodrine, ritonavir, Robitet 500, rosiglitazone, S2 Inhalant, Saizen, Salflex, salicylamide, salsalate, Salsitab, Saluron, Sandostatin, Sandostatin LAR Depot, Sandrena, saquinavir, saquinavir mesylate, Sarafem, Sectral, selegiline, Selestoject, Selgene, Serentil, Seroquel, Seroquel XR, Serostim, sertraline, Seudotabs, Slo-Niacin, Sloprin, sodium salicylate, sodium thiosalicylate, Solodyn, Solu-Cortef, Solu-Medrol, Solurex, Solurex LA, somatrem, somatropin, Somavert, Sorine, sotalol, Sotalol Hydrochloride AF, Sotalol Hydrochloride AF(obsolete), sparfloxacin, Sparine, St. Joseph Aspirin, St. Joseph Aspirin Adult Chewable, St. Joseph Aspirin Adult EC, Stanback Analgesic, stanozolol, Stelazine, Sterapred, Sterapred DS, Stilphostrol, Stress Maximum Strength, Striant, Sudafed, Sudafed 12-Hour, Sudafed 24-Hour, Sudafed Child Nasal Decongestant, Sudafed PE, Sudafed PE Extra Strength, Sudafed PE Quick Dissolve, Sudodrin, SudoGest, SudoGest 12 Hour, Sudogest PE, Sudrine, sulfADIAZINE, sulfADIAZINE sodium, sulfadoxine, sulfamethizole, sulfamethoxazole, sulfasalazine, Sulfazine, sulfiSOXAZOLE, Sumycin, Superfed, Suphedrin, Sus-Phrine Injection, Synthroid, SYSTEN, TAC 3, Tacaryl, Tace, Telzir, Temaril, temsirolimus, Tenormin, terbutaline, Terramycin, Testamone-100, Testim, Testim 5 g/packet, Testoderm, Testolin, Testopel, testosterone, Testosterone Cypionate, Testosterone Enanthate, testosterone propionate, testosterone topical, Testred, Testro, Testro AQ, Testro-L.A., Tetracap, Tetracon, tetracycline, Tev-tropin, THAIS, THAISSEPT, Thalitone, Therapy Bayer, thiethylperazine, thioridazine, Thiosulfil Forte, Thorazine, Thyrogen, thyroid desiccated, Thyrolar-1, Thyrolar-1/2, Thyrolar-1/4, Thyrolar-2, Thyrolar-3, thyrotropin alpha, timolol, timolol hemihydrate ophthalmic, timolol ophthalmic, timolol ophthalmic long-acting, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE, tipranavir, Tirosint, Toprol-XL, Torecan, Torisel, torsemide, Tramacort-D, Trandate, trandolapril, tranylcypromine, Tri-Buffered Aspirin, Triam-A, Triam-Forte, triamcinolone, triamcinolone acetonide, triamcinolone diacetate, triamcinolone hexacetonide, Triamcot, Triaminic A.M., Triaminic Infant Drops, Triaminic Softchews Allergy Congestion, Triaminic Thin Strips Cold, Triaminic Thin Strips Infant Decongestant, Triaminic Thin Strips Nasal Congestion, Triaminic Toddler Congestion Thin Strips, Triamonide 40, trichlormethiazide, TriCor, tr***uoperazine, tr***upromazine, Triglide, Trilafon, Trilog, Trilone, trimeprazine, Triostat, Tristoject, troglitazone, trovafloxacin, Trovan, Truxazole, Tusal, Twinject Auto-Injector, Twinject Auto-Injector Two Pack, Tylenol Simply Stuffy, U-Tri-Lone, Unifed, Unithroid, Univasc, V-Gan-25, V-Gan-50, Vagifem, Valergen, Vasotec, Vasoxyl, Vectrin, Ventolin, Ventolin HFA, Ventolin Nebules, Ventolin Rotacaps, Vibra-Tabs, Vibramycin, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin Monohydrate, Viracept, Virilon, Virilon IM, Visken, vitamin B3, Vivelle, Vivelle-Dot, VIVELLEDOT, Volmax, vorinostat, VoSpire ER, Westhroid, Westrim, Westrim LA, Winstrol, Wyamine Sulfate Injection, YSP Aspirin, Yutopar, Zagam, Zagam Respipac, Zaponex, Zaroxolyn, Zebeta, Zelapar, Zero-Order Release, Zestril, ziprasidone, Zolinza, Zoloft, Zorbtive, Zorprin, Zumenon, Zyprexa, Zyprexa Zydis,
Major Adverse Drug reactions from administration of Nolvadex(Tamoxifen Citrate)
MAJOR INTERACTIONS
amiodarone, anisindione, Anzemet, arsenic trioxide, Avelox, Avelox I.V., bepridil, Betapace, Betapace AF, Betapace AF(obsolete), Cardioquin, cisapride, Cordarone, Cordarone I.V., Corvert, Coumadin, dalfopristin, dicumarol, Diskets, disopyramide, disopyramide extended release, dofetilide, dolasetron, Dolophine, droperidol, gat***oxacin, Geodon, grepafloxacin, Halfan, halofantrine, ibutilide, Inapsine, Jantoven, levomethadyl acetate, Mellaril, Mellaril-S, ****ridazine, methadone, Methadose, Miradon, mitomycin, mox***oxacin, Mutamycin, Norpace, Norpace CR, Orap, Orlaam, Pacerone, pimozide, procainamide, procainamide 12 hour extended release, procainamide extended release, Procan SR, Procanbid, Pronestyl, Pronestyl-SR, Propulsid, Quadramet, Quin-G, Quin-Release, Quinaglute Dura-Tabs, Quinidex Extentabs, quinidine, quinidine extended release, Quinora, Ranexa, ranolazine, Raxar, samarium sm 153 lexidronam, Serentil, Sorine, sotalol, Sotalol Hydrochloride AF, Sotalol Hydrochloride AF(obsolete), sparfloxacin, Tequin, Tequin Teqpaq, thalidomide, Thalomid, thioridazine, Tikosyn, Trisenox, Vascor, warfarin, Zagam, Zagam Respipac, ziprasidone,
tamoxifen and mox***oxacin (Major Drug-Drug)
MONITOR CLOSELY: Certain quinolones, including gat***oxacin and mox***oxacin, may cause dose-related prolongation of the QT interval in some patients. Coadministration with other agents that can prolong the QT interval may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential related to their effects on cardiac conduction. During postmarketing surveillance, rare cases of torsade de pointes have been reported in patients taking gat***oxacin. These cases primarily involved patients with underlying medical conditions for which they were receiving concomitant medications known to prolong the QTc interval. Rare cases of tachycardia have been reported with mox***oxacin. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).
MANAGEMENT: Caution is recommended when gat***oxacin or mox***oxacin is administered concomitantly with drugs that prolong the QT interval, especially to patients with underlying risk factors. Since the magnitude of QTc prolongation increases with increasing plasma concentrations of the quinolone, recommended dosages and intravenous infusion rates should not be exceeded. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitations, or syncope.
MODERATE DRUG INTERACTIONS
abarelix, Adapin, Adeno-jec, Adenocard, Adenoscan, adenosine, adenosine monophosphate, adenosine triphosphate, Adgan, Adrenocot, Adrenocot L.A., Adriamycin, Adriamycin RDF, Alfenta, alfentanil, alfuzosin, alfuzosin extended release, Aloxi, aminoglutethimide, amitriptyline, amobarbital, amoxapine, Amytal Sodium, Anafranil, anastrozole, Anergan 50, Antinaus 50, Anturane, APO-Go, APO-Go Pen, Apokyn, apomorphine, aprepitant, Aralen Hydrochloride, Aralen Phosphate, Arava, Arimidex, armodafinil, Asendin, astemizole, Aventyl HCl, Avonex, Avonex Prefilled Syringe, azithromycin, Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, azithromycin extended release, Betaseron, bexarotene, Biaxin, Biaxin XL, Biaxin XL-Pak, bosentan, Brethaire, Brethine, Bricanyl, Busodium, butabarbital, butalbital, Butisol Sodium, carbamazepine, carbamazepine extended release, Carbatrol, Cardizem, Cardizem CD, Cardizem LA, Cardizem Monovial, Cardizem SR, Cartia XT, Celebrex, celecoxib, Cerebyx, Cerubidine, chloroquine, chloroquine hydrochloride, chloroquine phosphate, chlorproMAZINE, chlorproMAZINE extended release, cinacalcet, Cipro, Cipro Cystitis Pack, Cipro I.V., Cipro XR, ciprofloxacin, ciprofloxacin extended release, clarithromycin, clarithromycin extended release, clofarabine, Clolar, clomiPRAMINE, Compazine, Compazine Spansule, Compro, conivaptan, Cortastat, Cortastat 10, Cortastat LA, Cytadren, Dalalone, Dalalone D.P., Dalalone L.A., dasatinib, DAUNOrubicin, DAUNOrubicin liposomal, Daunoxome, De-Sone LA, Decadron, Decadron 5-12 Pak, Decadron Phosphate, Injectable, Decadron-LA, Decaject, Decaject L.A., desipramine, Dexacen-4, Dexacort Phosphate in Respihaler, Dexacort-LA, Dexacorten, dexamethasone, dexamethasone acetate, Dexamethasone Intensol, dexamethasone sodium phosphate, Dexasone, Dexasone LA, Dexone, Dexone LA, Dexpak Jr. Taperpak, Dexpak Taperpak, Di-Phen, Dilacor XR, Dilantin, Dilantin Infatabs, Dilantin Kapseals, Dilantin-125, Diltia XT, diltiazem, diltiazem 24 hour extended release, diltiazem extended release, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, doxepin, Doxil, DOXOrubicin, DOXOrubicin liposomal, E-Mycin, E.E.S. Granules, E.E.S.-200, E.E.S.-400, E.E.S.-400 Filmtab, echinacea, efavirenz, Elavil, Ellence, Emend, Emend 3-Day, Endep, epirubicin, Epitol, Equetro, Ery-Tab, Eryc, EryPed, EryPed 200, EryPed 400, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, Erythrocot, erythromycin, erythromycin base, erythromycin estolate, erythromycin ethylsuccinate, erythromycin lactobionate, erythromycin stearate, Factive, felbamate, Felbatol, FK506, flecainide, Floxin, Floxin I.V., Fluothane, fluphenazine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine hydrochloride, fluvoxamine, Folex PFS, Foradil Aerolizer, formoterol, Fortovase, fosphenytoin, Fulvicin P/G, Fulvicin U/F, gadobenate dimeglumine, gem***oxacin, Genotropin, Genotropin Miniquick, Gleevec, Grifulvin V, Gris-PEG, Grisactin 250, Grisactin 500, Grisactin Ultra, Griseofulicin, Griseofulvic, griseofulvin, griseofulvin microsize, griseofulvin ultramicrosize, Haldol, Haldol Decanoate, haloperidol, haloperidol decanoate, halothane, Hexadrol, Hexadrol Phosphate, Hismanal, Humatrope, hypericum perforatum, Idamycin PFS, idarubicin, Ilosone, Ilotycin Gluceptate, imatinib, imipramine, imipramine pamoate, interferon beta-1a, interferon beta-1b, Invega, Invirase, itraconazole, Ketek, Ketek Pak, Lamisil, lapatinib, Largon, Lariam, leflunomide, Levaquin, Levaquin Leva-Pak, Levitra, levofloxacin, Levoprome, Lorelco, Ludiomil, Luminal, Luvox, maprotiline, maraviroc, Mebaral, Medidex, Medidex LA, mefloquine, mephobarbital, methdilazine, methotrexate, methotrimeprazine, mibefradil, Mifeprex, mifepristone, modafinil, Multihance, MY-E, My-O-Den, Mycobutin, Mysoline, naltrexone, nateglinide, Nebupent, nefazodone, nelfinavir, Nembutal, Nembutal Sodium, nevirapine, Norditropin, Norditropin Cartridge, Norditropin Nord***ex Pen, norfloxacin, Noroxin, Norpramin, nortriptyline, Norvir, Norvir Soft Gelatin, Noxafil, Nutropin, Nutropin AQ, Nutropin Depot, Nuvigil, ofloxacin, Omnitrope, ondansetron, Ormazine, oxcarbazepine, paliperidone, palonosetron, Pamelor, PCE Dispertab, Pentam 300, pentamidine, Pentazine, pentobarbital, Perforomist, Permitil, perphenazine, Pharmorubicin PFS, Pharmorubicin RDF, Phenadoz, Phenazine 50, Phenergan, Phenergan Fortis, phenobarbital, Phenoject-50, phenylbutazone, Phenytek, phenytoin, phenytoin extended release, Phenytoin Sodium, Prompt, Pitressin, Plenaxis, posaconazole, Posicor, Priftin, Primethasone, primidone, Pro-Med, probucol, prochlorperazine, prochlorperazine extended release, Procot, Prograf, Prolixin, Prolixin Decanoate, Prolixin Enanthate, Promacot, promazine, promethazine, Promethegan, propafenone, propafenone extended release, propiomazine, Proquin XR, Prorex, protriptyline, Protropin, Provigil, QM-260, Qualaquin, quetiapine, quetiapine extended release, quinine, Rapamune, Rebif, ReVia, Rezulin, Rheumatrex Dose Pack, rifabutin, Rifadin, Rifadin IV, rifampin, rifapentine, Rimactane, Risperdal, Risperdal Consta, Risperdal M-Tab, risperidone, ritonavir, Robimycin, RU-486, Rythmol, Rythmol SR, Saizen, saquinavir, saquinavir mesylate, secobarbital, Seconal Sodium, Selzentry, Sensipar, Seroquel, Seroquel XR, Serostim, Serzone, Sinequan, sirolimus, Solfoton, Solurex, Solurex LA, somatrem, somatropin, Sparine, Sporanox, Sprycel, St. John's wort, Starlix, Stelazine, sulfinpyrazone, Surmontil, Sustiva, Tacaryl, tacrolimus, Tambocor, Targretin, Taztia XT, Tegretol, Tegretol XR, telithromycin, Temaril, terbinafine, terbutaline, terfenadine, Tev-tropin, thiethylperazine, thioguanine, Thorazine, Tiazac, tizanidine, Tofranil, Tofranil-PM, Torecan, Tracleer, Trexall, tr***uoperazine, tr***upromazine, Trilafon, Trileptal, trimeprazine, trimipramine, troglitazone, Tykerb, Uprima, Uroxatral, V-Gan-25, V-Gan-50, Vanatrip, Vaprisol, vardenafil, vasopressin, VFEND, Viracept, Viramune, Vivactil, Vivitrol, voriconazole, Z-Pak, Zanaflex, Zithromax, Zithromax IV, Zithromax TRI-PAK, Zithromax Z-Pak, Zmax, Zofran, Zofran ODT, Zorbtive,
Moderate DRUG-FOOD INTERACTION
MONITOR: Grapefruit juice may increase the plasma concentrations of some orally administered drugs that are substrates of the CYP450 3A4 isoenzyme. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.
MANAGEMENT: Patients who regularly consume grapefruits and grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that are metabolized by CYP450 3A4. Grapefruits and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact with these drugs.
