15mg of Anavar

I've been researching anavar and found a couple of interesting ones.

Short-term oxandrolone administration stimulates net muscle protein synthesis in young men.

Sheffield-Moore M, Urban RJ, Wolf SE, Jiang J, Catlin DH, Herndon DN, Wolfe RR, Ferrando AA.

Department of Surgery, University of Texas Medical Branch, and Shriners Burn Hospital for Children, Galveston 77550, USA. [email protected]

Short term administration of testosterone stimulates net protein synthesis in healthy men. We investigated whether oxandrolone [Oxandrin (OX)], a synthetic analog of testosterone, would improve net muscle protein synthesis and transport of amino acids across the leg. Six healthy men [22+/-1 (+/-SE) yr] were studied in the postabsorptive state before and after 5 days of oral OX (15 mg/day). Muscle protein synthesis and breakdown were determined by a three-compartment model using stable isotopic data obtained from femoral arterio-venous sampling and muscle biopsy. The precursor-product method was used to determine muscle protein fractional synthetic rates. Fractional breakdown rates were also directly calculated. Total messenger ribonucleic acid (mRNA) concentrations of skeletal muscle insulin-like growth factor I and androgen receptor (AR) were determined using RT-PCR. Model-derived muscle protein synthesis increased from 53.5+/-3 to 68.3+/-5 (mean+/-SE) nmol/min.100 mL/leg (P < 0.05), whereas protein breakdown was unchanged. Inward transport of amino acids remained unchanged with OX, whereas outward transport decreased (P < 0.05). The fractional synthetic rate increased 44% (P < 0.05) after OX administration, with no change in fractional breakdown rate. Therefore, the net balance between synthesis and breakdown became more positive with both methodologies (P < 0.05) and was not different from zero. Further, RT-PCR showed that OX administration significantly increased mRNA concentrations of skeletal muscle AR without changing insulin-like growth factor I mRNA concentrations. We conclude that short term OX administration stimulated an increase in skeletal muscle protein synthesis and improved intracellular reutilization of amino acids. The mechanism for this stimulation may be related to an OX-induced increase in AR expression in skeletal muscle.

JohnnyB

That hyper word, just means high protien, if you didn't all ready know:D

Combined effects of hyperaminoacidemia and oxandrolone on skeletal muscle protein synthesis.

Sheffield-Moore M, Wolfe RR, Gore DC, Wolf SE, Ferrer DM, Ferrando AA.

Department of Surgery, University of Texas Medical Branch, Galveston 77550, USA. [email protected]

We investigated whether the normal anabolic effects of acute hyperaminoacidemia were maintained after 5 days of oxandrolone (Oxandrin, Ox)-induced anabolism. Five healthy men [22 +/- 3 (SD) yr] were studied before and after 5 days of oral Ox (15 mg/day). In each study, a 5-h basal period was followed by a 3-h primed-continuous infusion of a commercial amino acid mixture (10% Travasol). Stable isotopic data from blood and muscle sampling were analyzed using a three-compartment model to calculate muscle protein synthesis and breakdown. Model-derived muscle protein synthesis increased after amino acid infusion in both the control [basal control (BC) vs. control + amino acids (C+AA); P < 0.001] and Ox study [basal Ox (BOx) vs. Ox + amino acids (Ox+AA); P < 0.01], whereas protein breakdown was unchanged. Fractional synthetic rates of muscle protein increased 94% (BC vs. C+AA; P = 0.01) and 53% (BOx vs. Ox+AA; P < 0.01), respectively. We conclude that the normal anabolic effects of acute hyperaminoacidemia are maintained in skeletal muscle undergoing oxandrolone-induced anabolism.

JohnnyB

Interesting. I wonder how bridging with running just short cycles of Anavar would work.

Pain

It would defiantly help keep muscle and maybe add some, as a bridge. With an anavar bridge I'd add some creatine they are synergistic together, with some glutamine.

JohnnyB

Almost all AAS increase protein synthesis while inhibiting breakdown. Showing that it continued 5 days after administration stopped doesn't say much to me. I don't like anavar as a bridge because of its longer halflife. I think this study shows what most of us already know. AAS work. Still always good to see the medical community conducting studies. They seem to do a lot at the University of Texas.

I think it also show that the high the doses people are using, don't need to be used to get protein synthesis working in your favor. If we look at the BBs of the 60s and 70s they(most, if not all) did lower dose cycles, then first timers do now. They didn't have all the sides that are around now. Sergio Oliva, Arnold and other didn't show any signs of gyno. They relied on training and nutrition rather then AAS to build their physiques. AAS is supposed to help with building your body not do all the work.

I've heard Bros say my gains have stopped should I up my dose. No. Up your calories. If you've gained 5-10lbs in the first part of your cycle and then plateau. You've reached the limit of your calorie intake. It's not because the AAS isn't working.

I think it show that we have gone overboard on some of the cycle people are using today.

I've been doing some research on anavar and read a thread at a board (can't remember where) where a Bro said he used 20mg of anavar for a bridge and made some gains. He was told that 20mg wouldn't do anything, that he needed at least 40mg, but more like 50mg to see gains with anavar.

More is not better, unless it's protein:sot:

JohnnyB