Lets put an end to the Prami hating ...

[jimmyinkedup]

So I personally love prami. I use it alot but so often I see people bashing it and touting caber. Now I have used Caber and I didnt like its effect nearly as much as I like prami for several reasons. Lets take a look at the compounds. See where they are similar, see where they are different, and see why in my opinion Prami is a clear choice when it comes to a dopamine agonist for our purposes.

So both compounds are dopamine agonists. The agonize activity at the dopamine receptor which causes increases in the levels of dopamine. Dopamine and Prolactin have an inverse relationship. In other words if one is high the other is low. So by increasing dopamine we can effectively reduce prolactin. Caber has a longer half life, prami a shorter one. So what the difference? Well they impact different dopamine receptors. There are 4 dopamine receptors and they are responsible for different functions. Caber acts primarily on d2 receptors which has an effect on reducing prolactin. Sounds great. Well Prami acts significantly on d 2,3,and 4 receptors. The functions of these receptors are as follows d2-treats hyperprolactemia. d3 is crucial for male sexual function. d4 is essential in the area of neuroprotectivity and anti oxidant properties. As you can see Prami offers the same benefits of caber but in addition several more. Particularly of note is the effect prami has on gh - increasing it substantially, the effect on sexual function, and the neuroprotective benefits.

Sides. This drives me crazy. All I hear is I hate prami it makes me sick . All you need to do is start low and slowly increase dosage. Problem solved. Now lets take a look at Caber and its side effects. Well first of it bears mentioning that 79% of people who take Caber have adverse side effects. Its also bears mentioning that a primary side of caber is severely impaired liver function and choleostasis. Another is it causes Vavular Heart Disease! Not with Prami! While Prami has sides they are minor compared to the above in frequency and severity.

Somehow along the way things get twisted and info misconstrued. The fact is Prami has less dangerous and less frequent sides, impacts more beneficial areas than caber, has a shorter half life so can be taken "as needed" doesn't have to steadily be taken like caber.

See Sometimes i use something and it works really well for me but i hear so much contradictory info that I have to look into it. This was exactly the case here. All in all man, in my opinion, Prami is the clear cut choice hands down - for me anyway. If you haven't tried it rather than parrot misinformation give it a go..its a pretty damn impressive fun compound. Sexual benefits are insanely amazing, sense of well being , deep sleep , reduces prolactin quickly, easily and readily available.

Next 19 nor cycle have prami an hand and give it a go...if its your first time or if its been a while. Do so with an open mind and I think you will be very pleased.

Refs:
*a b c d Kvernmo T, Härtter S, Burger E (August 2006). "A review of the receptor-binding and pharmacokinetic properties of dopamine agonists". Clinical Therapeutics 28 (8): 1065–78. doi:10.1016/j.clinthera.2006.08.004. PMID 16982285.

* a b Newman-Tancredi A, Cussac D, Audinot V, et al. (November 2002). "Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor". The Journal of Pharmacology and Experimental Therapeutics 303 (2): 805–14. doi:10.1124/jpet.102.039875. PMID 12388667.

* "MedlinePlus Drug Information: Pramipexole (Systemic)". United States National Library of Medicine. Archived from the original on 2006-09-26. Retrieved 2006-09-27

*Schade, Rene; Andersohn, Frank; Suissa, Samy; Haverkamp, Wilhelm; Garbe, Edeltraut (2007-01-04). "Dopamine Agonists and the Risk of Cardiac-Valve Regurgitation". New England Journal of Medicine 356 (1): 29–38. doi:10.1056/NEJMoa062222. PMID 17202453

* Zanettini, Renzo; Antonini, Angelo; Gatto, Gemma; Gentile, Rosa; Tesei, Silvana; Pezzoli, Gianna (2007-01-04). "Valvular Heart Disease and the Use of Dopamine Agonists for Parkinson's Disease". New England Journal of Medicine 356 (1): 39–46. doi:10.1056/NEJMoa054830. PMID 17202454


Discuss?

[sirupate]

Thank you. Very interesting. How does one go about establishing a dose/dosing schedule for their research subjects? Is this an injectible sub-q thing, or an oral?

[jimmyinkedup]

It is oral liquid. I start at .25mg for several days (like 5 -7) then up to .5mg ed. I have used .75mg/day but usually end up taking .5mg ed at night right before bed.

[FONZY007]

I've never used prami or caber but again want to when I use deca ..

Controlling prolactin help control Estrogen correct so in turn will control acne?

[AnabolicDoc]

That's exactly how it's dosed medically for RLS. Great post/thread Jimmy!

[Juced_porkchop]

That's exactly how it's dosed medically for RLS. Great post/thread Jimmy!

Agreed! awesome post!

[Juced_porkchop]

I've never used prami or caber but again want to when I use deca ..

Controlling prolactin help control Estrogen correct so in turn will control acne?

you should control estrogen AND prolactin , not just one.
an AI and prami is a good idea.
for me O ALWAYS have prami on hand even though I haven't needed to use it with low doses of deca ( 300mg ew) I have it just in case or if i decide to bump of deca dose. but still used an AI because I was also on 500mg teste ew.

[FONZY007]

you should control estrogen AND prolactin , not just one.
an AI and prami is a good idea.
for me O ALWAYS have prami on hand even though I haven't needed to use it with low doses of deca ( 300mg ew) I have it just in case or if i decide to bump of deca dose. but still used an AI because I was also on 500mg teste ew.

Ok sounds good

[clarky.]

thanks for sharing your knowledge on this jimmy I have never used any of them but I was just looking them up the other day for my next cycle to keep to hand I was going to go with prami anyway because of the heart thing

what do you think of bromo and do you run your prami the full lenth of your cycle

[jimmyinkedup]

thanks for sharing your knowledge on this jimmy I have never used any of them but I was just looking them up the other day for my next cycle to keep to hand I was going to go with prami anyway because of the heart thing

what do you think of bromo and do you run your prami the full lenth of your cycle

Im not a bromo fan. I think its the worst option actually.
I dont run it all the time. I run it when i run test, low dose deca , and tren together. With just test and say low dose deca I dont need it.

[clarky.]

Im not a bromo fan. I think its the worst option actually.
I dont run it all the time. I run it when i run test, low dose deca, and tren together. With just test and say low dose deca I dont need it.

ok i'll not bother reading about bromo then thanks

i'll do some reading up on prami thanks mate

[jimmyinkedup]

ok i'll not bother reading about bromo then thanks

i'll do some reading up on prami thanks mate

no worries buddy!

[evander87]

Thank you Jimmy. I'm running caber right now on my first ever tren cycle and I can't sleep. I'm planning on taking prami next cycle. This confirms my thoughts. Thanks again.

[jimmyinkedup]

Thank you Jimmy. I'm running caber right now on my first ever tren cycle and I can't sleep. I'm planning on taking prami next cycle. This confirms my thoughts. Thanks again.

no prob. let us know how it goes when you do use it!

[REBORN52]

Jimmy is dead on. The ONLY slight side ive had with Prami is minor nausea the first couple of wks and that goes away after a couple weeks. I sleep like a baby on it...

[auswest]

I've been using it on this tren cycle I started a little high at .25 and it hit me for six, if you do not build up slowly you are in for a hell of a time with fatigue and nausea.. over the last 14 days I have slowly tapered up to .5 which is the dose I will continue, I also usually suffer from rls over the evening when I'm tired and this has not been an issue since using prami, so far no bad sides, unable to speak of positive sides as there are many other things that may be contributing to increased sex drive ect, I have been dosing before bed as it really makes me tired.

[austinite]

Great post and excellent timing, Jimmy. Thank you.

[gymfu]

Hum.....I was unaware I needed to tapper up so slowly. I tried Parami a couple years back on my first deca cycle and I'm sorry but the sides were unbearable, and I can put up with a lot in the name of bodybuilding. Couldn't sleep at night made me VERY groggy durring the day.

But, I guess I should try again after reading this. Since I seem to be so sensitive to it I will report my findings.

[AnabolicDoc]

That's exactly how it's dosed medically for RLS. Great post/thread Jimmy!

I just double checked, for RLS the recommended dosing is;

restless legs syndrome, mod-severe primary
[0.125-0.5 mg PO qpm]
Start: 0.125 mg PO qpm, may incr. by 0.125 mg/day q4-7 days; Max: 0.5 mg/day; Info: give 2-3h before bedtime; taper dose gradually to D/C

(cut and pasted from Epocrates)

[austinite]

Hum.....I was unaware I needed to tapper up so slowly. I tried Parami a couple years back on my first deca cycle and I'm sorry but the sides were unbearable, and I can put up with a lot in the name of bodybuilding. Couldn't sleep at night made me VERY groggy durring the day.

But, I guess I should try again after reading this. Since I seem to be so sensitive to it I will report my findings.

Oh yeah. I tried starting at .5 once. Keyword.... "Once". But after ramping up from .25 it wasn't so bad. Especially since I started taking it right before I pass out.

[C3RB3RUS]

Thank you Jimmy. I'm running caber right now on my first ever tren cycle and I can't sleep. I'm planning on taking prami next cycle. This confirms my thoughts. Thanks again.

you might have a hard time sleeping on it the first two, or three nights. The batch i'm taking gives me eyelid hallucinations; the sleep is okay. of course my cycle is weak i think, so insomnia hasn't really been a huge issue, just gas!

[sirupate]

It is oral liquid. I start at .25mg for several days (like 5 -7) then up to .5mg ed. I have used .75mg/day but usually end up taking .5mg ed at night right before bed.

I've got prami on the way and will give it a try. Did some other reading on prami and think I will start out at about half what you recommended as an initial dose. I don't need the nausea and sleep cycle disturbance some have reported, however, they may have been taking a higher dose. Really trying this for hgh booste, better sleep and libido boost.

I'll report back if I find anything interesting about prami. Thanks,

Jeff

[JohnnnyBlazzze]

I've used prami in the past and using it here in a few weeks .

Pay close attention to the tapering, the nausea is not a good time if you start your dose to high ;(

[youngtali]

i was wondering if i should run prami with ghrp 6 and cjc 1293

[WMSuperSport]

Been on. 25mg for 3 days and I've noticed being super tired lately. I've also been busy with work and a million other things so it could be that instead. No nausea but ill taper up

[Juced_porkchop]

i was wondering if i should run prami with ghrp 6 and cjc 1293

Although there may be a slight rise in prog as I have seen noted, I have never needed to use prami on this peptide cycle myself.
I dont think it would be needed imo, and if anything i would stop if i had issue , but on cycle it is what it is.
Maybe have it on hand? I cant say much since I havent used it on peps or found much on its use on peptide cycles.

I would rec sermorelin in place of the cjc, but both are good.

[ghettoboyd]

another kick ass post jimmy...I had no intentions to ever use parami due to the bro science/experiences that was being parroted and the fact that I have access to caber(which as you know isn't cheap)and the awesome sexual side effects it creates...I didn't think it (parami) could be any better but as usual I am enlightened by your research/experiences...I am now going to give it a go...thanks buddy...

[Live for the PUMP]

Great information Jimmy. Where do you get all this knowledge!

So I just ordered liquid Prami (this post makes me feel real good about that ). I am doing a Test P and NPP cycle. Never used Prami. Should I just start day 1 with taking Prami at .25? Or should I use "as needed"? If I should use as needed please tell me how I will know I need it.

Thanks
LFTP

[Sfla80]

Great information Jimmy. Where do you get all this knowledge!

So I just ordered liquid Prami (this post makes me feel real good about that ). I am doing a Test P and NPP cycle. Never used Prami. Should I just start day 1 with taking Prami at .25? Or should I use "as needed"? If I should use as needed please tell me how I will know I need it.

Thanks
LFTP

Gonna bump tis question too.

[bigspin]

its also so much cheaper than caber

[jimmyinkedup]

If you manage estrogen well on cycle you may not need a dopamine agonist at all. Signs you do would be sexual side effects and lactation. Always have prami on hand when running a 19 nor steroid (deca ,NPP,tren ) Hope that helps!

[Live for the PUMP]

If you manage estrogen well on cycle you may not need a dopamine agonist at all. Signs you do would be sexual side effects and lactation. Always have prami on hand when running a 19 nor steroid (deca,NPP,tren) Hope that helps!

Helps a lot. Thanks Jimmy.