Elite Fitness Newsletter on Clomid

Anybody read the latest Elite Fitness Newsletter on Clomid? Just wondering what everybody’s opinion was on it. If nobody gets the newsletter let me know and I'll post it. It's a pretty long article

please post or email me the article, i'd like to read it!
thanks

Like everyone else who has ever read a single book (or every book for that matter) on the proper use of anabolics, I usually included a course of Clomid after each cycle. It was the responsible thing to do. So they say. There was just one little problem with this procedure. It seemed to make the recovery and the return of libido, testicular size, sperm count, seminal volume and normal testosterone levels worse. How can this be? Maybe I was just a weird exception to the rule. One doctor suggested I might have some bizarre feedback loop that gave the drug its negative effects. Maybe I was crazy. Maybe not.

The simple truth of the matter is this: the thinking on Clomid is based on some very sketchy evidence which has been parroted endlessly among the bodybuilding community. In a way, I'm at fault myself. Allow me to explain.

A few years back, I co-wrote an article with Brock Strasser called "The Steroid Summit." In that piece, I mentioned Clomid and ejaculate volume. Where I was going with this was the fact that I noticed a definite decrease in ejaculate volume and this would indicate that Clomid wasn't doing what it was supposed to do. Brock replied "Oh yeah, Clomid will definitely increase ejaculate" and he went on to say how male porn stars are using it to enhance their "bursts of drama" so to speak. We were tackling a lot of topics and I didn't want to dispute his contention so I let it go. At any rate, wouldn't you know... the rumor about porn stars and Clomid ran rampant. I started hearing it everywhere, even in places unassociated with bodybuilding.

I knew I couldn't be the only person experiencing negative effects from Clomid so I did a little personal survey. It turns out I wasn't as weird as I thought. Out of over 100 bodybuilders I questioned, about 1 in 4 experienced in the use of steroids and aromatase blockers admitted that Clomid didn't have the effects they were hoping for. Many also claimed that Nolvadex, which has a very similar structure to Clomid, caused a loss in libido and a weak ejaculation. Even among those who felt it helped them, there were complaints about "emotional distress" and "weepiness", both of which suggest an increase in estrogen. So how can anyone be sure Clomid is actually beneficial?

Still, the rumors persist.

I was on a popular internet message board recently and someone was claiming that they weren't getting back their atrophied testicles even after using 50mgs of Clomid for two weeks. The resident "guru" suggested taking 100mgs for another two weeks. This line of thinking is straight from the middle ages when doctors prescribed leeches to cure a disease -- if the patient got sicker from the treatment the solution was; more leeches! Ridiculous? Of course. Some things never change.

There are several major problems associated with Clomid, as well as Arimidex, Nolvadex, Teslac or any other estrogen blocker. For one thing, all these compounds are indiscriminate in how much estrogen they block. So what's bad about that? Well, the whole point of using an anti-estrogen is to protect against the spillover of estrogen that comes with the excessive use of androgens. If the body can't metabolize all that testosterone, it aromatizes into estrogens. What the experts fail to address is the fact that the amount of aromatization varies greatly from individual to individual. If the steroid dosages are moderate, there might not be any aromatization of any consequence, and the anti-estrogens may lower levels below what they were normally! And keep one very important fact in mind. A little estrogen in men is necessary for a healthy libido. (It's also necessary for other things such as bone density, skin tone, etc., but I can't think of anything more important to most men than their dicks.)

More recently, it has even been suggested that estrogen may play a role in the proliferation of androgen receptors. This may explain why some experienced steroid users claim that they get decreased results when adding an anti-estrogen to their stack. It was once thought that anti-estrogens such as Nolvadex decreased IGF-1, but this has not been validated with any concrete evidence. Nevertheless, studies done on rats found that androgen receptor binding was dramatically increased after the administration of estradiol, increasing the anabolic potency of the androgenic steroid. If nothing else, this shows that estrogen is, on some level, directly or indirectly involved in the process of promoting muscle growth. There's also the added element of strength and size gains due to the water retention that estrogen inflicts. And just as a kicker, anti- estrogens may also increase sex hormone binding globulin which is the last thing you want when coming off a cycle.

In the case of Clomid, the effects may be even worse than other anti-estrogens since Clomid is a mild estrogen itself. The basic theory behind its use (which is sounding more and more stupid every day) is essentially that the Clomid will occupy the estrogen receptor sites thus disallowing the formation of more estrogen. Maybe. What's more likely in cases where estrogen levels are normal, the Clomid will simply add more estrogen. This may the reason for some people's apparent aversion to Clomid and its estrogen-like side effects.

Even if Clomid did lower estrogen, there's no evidence that lower estrogen will necessarily lead to increased testosterone, yet this is the premise which everyone follows. Clomid has also been known to produce a decrease in the LH response to LH releasing hormone. This is something that has been known for a while, (findings on this date as far back as 1978) yet curiously ignored. Naturally, studies aren't conducted to benefit the bodybuilder on steroids, so we must learn to read between the line sometimes. In doing so, conclusions can be drawn. All too often steroid gurus draw them incorrectly.

The notion of increased sperm count is also one of contention. Allow me to get technical for a moment and break my own rule about references for a second while I cite this quote from a study done on Clomid.

"Treatments with idiopathic oligospermia for six to nine months resulted in a significant increase in gonadotropin testosterone and estradiol levels. A significant increase in sperm density was observed only in subjects with low sperm count below normal basal FSH levels. In cases where sperm density increased, FSH levels decreased, suggesting an inhibitory effect."

What this suggests in plain English is that not everyone reacts to Clomid treatment in the same way and sperm levels must be abnormally suppressed for the drug to be of any benefit. And even in situations where that is the case, the side effect was lowered Follicle Stimulating Hormone, which as you may know, controls the amount of Leutinizing Hormone we release which in turn regulates how much testosterone we have. This is why so many bodybuilders claim to crash after coming off of the Clomid.

Judging from this information it's clear that Clomid, at best, is a crap shoot and its benefits, if any, are temporary. So why is everyone still taking it?

Next week, in part two of BottomLine Bodybuilding excerpt, Clomid The Big Lie, Nelson tells us why bodybuilders are still taking Clomid and making a big mistake! He also lets you in on some other drugs that really help you recover from a steroid cycle properly.

Great post...... I just wish he would have given a little more info on what he thinks is better for recovery.

Thanks BigD

Interesting, please keep us updated.

well.............that suck. my cycle ends in 2 weeks. talk about bringin a guy down. Hey BigD. would you mind posting the second part of this article next week?

thanks for the read bro! curious...please post next weeks if possible!

steve

BigD,

Thanks for posting this.

The author of the article writes:

Quote:

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Judging from this information it's clear that Clomid, at best, is a crap shoot and its benefits, if any, are temporary. So why is everyone still taking it?

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The author took a whole lot of words to say what he summed up in the above paragraph. I don't think that this article uncovers anything new. Anyone who has read this board or has compared his/her results with another's can easily conclude that steroids affect each person differently--that includes Clomid and the rest of the anti-e's.

The ONLY way a person will ever know how a steroid is going to affect him/her is to use it and note the changes. Yes, there are trends that a person can look at in order to get an idea of what to expect. For example, EQ will probably cause hunger pangs, increased vascularity and higher blood pressure. But, this trend does not mean that every person will experience the full force of these effects. Some people have terrible anxiety attacks on EQ; others have no side-effects. Bad results do not necessarily mean that you used a "bad" or "counterfeit" batch. Usually, unsatisfactory results are caused by the lack of proper nutrition. But, poor results and side-effects can also be attributed to one's body chemistry.

This is why I have always chosen to start with small amounts of something new before I use more. This way, I can find out how my body reacts before using more. Some people may not have the time, patience or money for this approach. To each his own.

Remember: just because you may not get adequate results from a product does not mean it is useless to everyone.

BASK8KACE - I hear what your saying but I think post cycle therapy is more important than the cycle itself. I want to know that what I'm taking for post cylce is working so I would rather gain 5lbs (not really) instead of 20lbs I just don't want to be shut down. I want my test levels back up and banging my girl like I was while I was on.

Quote:

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Originally posted by BASK8KACE
Remember: just because you may not get adequate results from a product does not mean it is useless to everyone.

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every new member should read this statement as it is 100% true and should be abided when someone criticizes a drug you want to use.

what was said in the clomid article makes sense, however i don't feel that it is good read for someone figuring out what to take post-cycle as it blows the drug out of the water.

other than the mood effects it has on me, it has always worked and served its purpose.

i'll stick with an anti-e post cycle and disregard one article from a source that makes sweeping generalizations and lacks citations for proof.

This may be a uneducated response, so please excuse my ignorance if I am wrong. I was under the impression that Clomid in itself was a weak, at best, anti-e. Rather, Clomid is used to "jump start" your testicles into regaining production of a normal test level, after having been shut down for a number of weeks from a cycle? Am I off the mark on Clomids' purpose?

Quote:

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Originally posted by JasonNew-b
This may be a uneducated response, so please excuse my ignorance if I am wrong. I was under the impression that Clomid in itself was a weak, at best, anti-e. Rather, Clomid is used to "jump start" your testicles into regaining production of a normal test level, after having been shut down for a number of weeks from a cycle? Am I off the mark on Clomids' purpose?

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You got it right. That's what most people use it for. :)

Quote:

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Originally posted by TheMudMan
BASK8KACE - I hear what your saying but I think post cycle therapy is more important than the cycle itself. I want to know that what I'm taking for post cylce is working so I would rather gain 5lbs (not really) instead of 20lbs I just don't want to be shut down. I want my test levels back up and banging my girl like I was while I was on.

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Mud, below is a post from William Llewellyn about post cycle recovery. This is the guide I follow when I come off (which is rare anymore these days:lol: ) I have found that even after year long cycles, HCG is the thing that gets me going again.

Understanding Post Cycle “T” Recovery
By William Llewellyn




O.K. You have been on an awesome 4-month cycle of Sustanon and Dianabol. You’ve gained a massive 20 lbs, and are extremely pleased with your results. You can’t stop looking in the mirror. But there is a problem now starting to eat away at you. You are going to run out of steroids very soon (you know you need a break anyway), and your testicles are the size of raisins. Your body is producing less testosterone than a 9-year-old girl, and you are scrambling to figure out what to do to avoid a nasty post-cycle crash that could potentially strip away some of your hard-earned muscle. The opinions on how to restore endogenous testosterone production post-cycle seem to be different everywhere you look. What option is best? Without an understanding of exactly what is going on in your body, and why certain compounds help to correct the situation, choosing the right post-cycle program can be quite confusing. In this article I would therefore like to discuss the role of anti-estrogens and HCG during this delicate window of time, while detailing an effective strategy for their use.



The Axis



The Hypothalamic-Pituitary-Testicular Axis, or HPTA for short, is the thermostat for your body’s natural production of testosterone. Too much testosterone and the furnace will shut off. Not enough, and the heat is turned up, to put it very simply. For the purposes of our discussion here we can look at this regulating process as having three levels. At the top is the hypothalamic region of the brain, which releases the hormone GnRH (Gonadotropin-Releasing Hormone) when it senses a need for more testosterone. GnRH sends a signal to the second level of the axis, the pituitary, which releases Luteinizing Hormone in response. LH for short, this hormone stimulates the testes (level three) to secrete testosterone. The same sex steroids (testosterone, estrogen) that are produced serve to counter-balance things, by providing negative feedback signals (primarily to the hypothalamus and pituitary) to lower the secretion of testosterone when too much of this hormone is sensed. Synthetic steroids, of course, suppress testosterone the same way. This quick background of the testosterone-regulating axis is necessary to furthering our discussion, as we need to first look at the underlying mechanisms involved before we can understand why natural recovery of the HPTA post-cycle is a slow process. Only then can we implement an ancillary drug program to effectively deal with it.



Testicular Desensitization


Although steroids suppress testosterone production primarily by lowering the level of gonadotropic hormones discussed above, the big roadblock to a restored HPTA after we come off the drugs is surprisingly not the level of LH itself. This problem is made clearly evident in a study published in Acta Endocrinologica back in 1975(1). Here blood parameters, including testosterone and LH levels, were monitored in male subjects whom were given testosterone enanthate injections of 250mg weekly for 21 weeks. Subjects remained under investigation for an additional 18 weeks after the drug was discontinued. At the start of the study, LH levels became suppressed in direct relation to the rise in testosterone, which is to be expected. Things looked very different, however, once the steroids had been withdrawn (see Figure I). LH levels went on the rise quickly (by the 3rd week), while testosterone barely budged for quite some time. In fact, on average it was more than 10 weeks before any noticeable movement started. This lack of correlation makes clear that the problem in getting androgen levels restored is not the level of LH, but in fact testicular atrophy and desensitization to this hormone. After a period of inactivation the testes have apparently lost mass (atrophied), making them unable to perform the workload required by heightened levels of LH.


Post-Cycle LH Levels


Post Cycle Testosterone Levels



Figure I. LH and Testosterone measurements starting 1 week after the last injection of 250mg of testosterone enanthate (pretreated measures were 5 mU/ml and 4.5 ng/ml respectively). Note that between weeks 1 and 5, as testosterone levels are declining due to the cessation of exogenous androgen administration, LH levels are already rebounding. From weeks 5 to 10 testosterone levels are at or very near baseline, to spite the substantial LH levels by this point. No significant increase in testosterone is noted until after the 10-week mark.



The Role of Anti-estrogens


It is important to understand that anti-estrogens alone do not do much to restore endogenous testosterone release after a cycle. Normally they only foster LH by blocking the negative feedback of estrogens, and we now see that LH rebounds quickly without help anyway. Plus, post cycle there is not an elevated level of estrogen for anti-estrogens to block, as testosterone (now suppressed) is a major substrate used for the synthesis of estrogens in men. Serum estrogen levels will actually be lower here as a result, not higher. Any estrogen rebound that occurs post-cycle likewise happens concurrently with a rebound in testosterone levels, not prior to it (note there is an imbalance in the ratio post cycle, but this is another topic altogether). We are seeing no mechanism in which anti-estrogenic drugs can really help here. We can see why this fact would not be difficult to overlook, however. The medical literature is filled with references showing anti-estrogenic drugs like Clomid and Nolvadex to increase LH and testosterone levels, and in normal situations these drugs do indeed increase endogenous androgen production by blocking the negative feedback of estrogens. Combine this with the fact that just as many studies can be found to show that steroid use lowers LH levels when suppressing testosterone, and we can see how easy it would be to jump to the conclusion that post-cycle we need to focus on restoring LH. We would miss the true problem of testicular desensitization unless we were really looking into the actual recovery rates of the hormones involved. When we do, we immediately see little value in using anti-estrogenic drugs.



HCG


So we now see, contrary to the dominating opinion of the times, that anti-estrogens alone will do little to raise testosterone levels in the early weeks of the post-cycle window. This leaves us to focus on a very different level of the HPTA in order to hasten recovery: the testes. For this we will need the injectable drug HCG. If you are not familiar with it, HCG, or Human Chorionic Gonadotropin, is a prescription fertility agent that mimics the bodies own natural LH. Although the testes are equally desensitized to this drug as LH (they both work through the same mechanism), we are administering it as a measured drug and are therefore not constrained by the limits of our own LH production. We similarly can use HCG to provide a bolus dose of LH (of our choosing), which works only to augment the recovering LH levels we already have in the body. In essence we are looking to shock them with an overwhelmingly high level of LH activity, coming from both endogenous and exogenous sources. We want it to reach a level far above what our body, even when supported by anti-estrogens, could possibly do on its own. The result can be a rapid restoration of original testicular mass and functioning, which would allow normal levels of testosterone to be output much sooner than without such an ancillary program. What we are looking at now is HCG actually being the pivotal post-cycle drug, while anti-estrogens are relegated to a supportive role at best.



Finalizing the Program


An ideal post-cycle recovery program will focus on two things really. The first is hitting the testes hard with HCG. It is important, however, not to overuse this drug. Taken for too long, or at too high a dosage, the LH receptor will actually become desensitized to LH(2) , which may further exacerbate our post-cycle problem instead of helping it (this is why I am not in favor of regular HCG use on-cycle). My experience with HCG has led me to feel comfortable using it for a course of three weeks, at a dosage of maybe 5000-7500IU weekly. Often the last week I limit the dose to 2,500IU, unless the cycle has been particularly long or potent. This is timed so at least half of the total administered drug dosage will be given when there is still exogenous steroid in the body. On our graph above this would be at about the 3-week mark after the last injection of testosterone. This will give the testes some time to get back into shape before the baseline is actually hit with T levels. Secondly, Anti-estrogens are used to play a supportive role at the same time, so 20mg of Nolvadex or 50-100mg of Clomid would typically be added ( my last article for Mind and Muscle discusses the comparative differences with these two agents). This is to combat the suppressive effects of estrogen as testosterone levels start to go back up, as well as potential side effects (HCG has been shown to increase testicular aromatase activity as well (3)). Although in the first couple of weeks the anti-estrogen does little, it may indeed be helpful when testosterone levels actually start to get back up near normal. To further stimulate the HPTA, and support continuingly high LH levels, the anti-estrogen remains to be used for 2 to 3 weeks after the HCG therapy has been stopped. A sample program, as it would be instituted in our sample post-cycle window, is provided below.



Sample Post-cycle Plan:


Week 3: 5000IU HCG total + 20mg Nolvadex daily
Week 4: 5000IU HCG total + 20mg Nolvadex daily
Week 5: 2500IU HCG total + 20mg Nolvadex daily
Week 6: 20mg Nolvadex daily
Week 7: 20mg Nolvadex daily
Week 8: 20mg Nolvadex daily



In Closing


I hope this article provided a well-needed new look at the mechanisms involved in post-cycle testosterone recovery. Indeed I believe it should debunk a commonly held belief these days, as we seen now that those advocating the sole use of Clomid post cycle are sorely missing the mark. The problem goes much deeper than just getting LH levels back. In fact, we see that LH doesn’t even need much help kicking back into gear, and a drug like Clomid will do very little to help this anyway in the absence of significant estrogen levels anyway. HCG is a drug with undeniable usefulness during the post-cycle window, and many bodybuilders have been much too quick to abandon it. It is truly fundamental to an effective recovery program, and would not consider any dose or combination of anti-estrogens or aromatase inhibitors capable of doing the job without it.


References:

1. Effect of long-term testosterone oenanthate administration on male reproductive function: Clinical evaluation, serum FSH, LH, Testosterone and seminal fluid analysis in normal men. J. Mauss, G. Borsch et al. Acta Endocrinol 78 (1975) 373-84

2. Desensitization to gonadotropins in cultured Leydig tumor cells involves loss of gonadotropin receptors and decreased capacity for steroidogenesis. Freeman DA, Ascoli M Proc Natl Acad Sci U S A 1981 Oct;78(10):6309-13

3. Acute stimulation of aromatization in Leydig Cells by Human Chorionic Gonadotropin In-vitro. Proc Natl Acad Sci USA 76:4460-3,1079

Thanks Butcher very interesting.....

This will most likely be the way I go for my post therapy in a few weeks. I will need to do a little more reading on this but it looks like a good plan. I would see posts on HCG for PCT and the responses were that it wasn't needed and clomid would do the trick.

Thanks

Great post! I'd love to see some of our Vets and Mods chime in with their thoughts.

Yeah I'd like to see what their thoughts are too. I'd also like to know if any of the mods I know are still around.

What's funny is if you look up the HCG thread in the Educational forum you'll notice right away that it is NOT recommended to be used during clomid, and especially not if you are prone to gyno/acne.

However, the thread just kinda ends without much info.

I'd be interesting in anything which covers the effects of HCG/clomid therapy at the same time, why would this NOT be recommended in the AR educational section?

CLOMID -- THE BIG LIE -- Part 2

Judging from the information it's clear that Clomid, at best, is a crap shoot and its benefits, if any, are temporary. So why is everyone still taking it?

Of course, this is hypothesis on my part and a lot of the pedants and pundits will refuse to acknowledge it. After all, all the pros use Clomid. Why should anyone listen to me? They don't have to, but they should.

I was speaking with Jerry Brainum on this very subject. I should mention, Jerry, unlike some of the self-appointed experts that abound on the internet and the world of underground newsletters, is one of the most knowledgeable people in the business on the subject of nutrition and pharmacology. He's been writing on the subject before most of these pseudo whiz kids were born. He knows everybody who is anybody in the world of bodybuilding. When I mentioned my theories about Clomid he said to me;

"You're not alone. I don't know a single pro who still uses Clomid."

This in itself speaks volumes. Of course, it may not be the best validation for my argument since there are plenty of pro bodybuilders who are complete jackasses when it comes to knowledge and application of anabolics. He or she usually hires someone who knows something, or more likely, can get something. The protocol is then to load the syringe to the top and keep shooting until the stash is gone. Nevertheless, the fact that Clomid has lost its allure among the higher echelon on the bodybuilding ranks is a sure sign it isn't working well. If it did, they'd all use it, even if they stayed on 365 days a year. Who wouldn't want to maintain testicular size and increase natural production while keeping estrogen low? If Clomid was effective in doing so, there'd be no reason to stop. They know what works and what doesn't. And they know that Clomid sucks. (Of course, there's always some lunkhead who doesn't catch on right away.)

One last thing to keep in mind: Back in the 60's and early 70's no one used anti-estrogens. Look at the pictures of the stars of that time and you'd be hard pressed to find a case of gyno anywhere. Food for thought.

The bottom line: If dosages are kept sane, Clomid wouldn't be needed -- even if it worked well, which it doesn't. Forget Clomid. For more effective methods of keeping excess estrogen in check, read on.

When it comes to anti-estrogens, the best bet may be not in occupying the receptor sites, as does Clomid, but to compete with the testosterone/estrogen balance. At one time, Proviron was deemed a valid choice as an anti-estrogen agent until some of the sophomoric steroid students argued that it didn't have any direct anti-estrogenic properties. True, but it still looks as if it's the best choice if you feel the need to guard against estrogen build up. It does so because DHT acts as a gyno antagonist. (Yet another thing that has been oddly overlooked.) Even when DHT is applied topically it's been shown to reduce gyno in cases where the gyno hadn't been a chronic condition.

Beyond the direct effect of DHT, Proviron has distinct benefits, the first being that as a derivative of DHT it isn't capable of forming estrogen, yet it has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than does testosterone. That means administering it with another aromatizable compound will prevent estrogen build up due to the fact that DHT binds to the aromatase enzyme so strongly. There's also been some suggestion that Proviron may downgrade the actual estrogen receptor, thereby making it twice as effective at reducing circulating estrogen levels. And because DHT has such a high affinity for SHBG it leaves more free testosterone to impart its anabolic effects.

It makes sense that the use of Proviron is a more practical and rational method of dealing with the possibility of excess estrogen than the aforementioned method of attempting to add a weaker estrogen in the hopes that it will prevent aromatization.

William Llewellyn touches upon this in Anabolics 2000. He says...

"(Proviron) is in contrast to Nolvadex which only blocks estrogen's ability to bind and activate receptors in certain tissues." (such as breast tissue)

In other words, the World Anabolic Reference was right when it stated; "Proviron cures the problem of aromatization at the root while Nolvadex simply cures the symptoms."

Proviron in moderate doses has been shown to be remarkably safe and free of side effects in most men. If you must use an anti-estrogen, Proviron is the way go.