Nolva and Clomid on my cycle

**OverDrive** · 06-21-2003, 05:48 PM

hey guys .. I know there are a tons of threads on this but for my particular cycle and stats what is recommended for Nolva and Clomid.

Keep Nolva on hand just in case or take it with my cycle?

Clomid I pretty much know to take 3 weeks after my last shot.

32 y.o 188lbs. bf 18-19% ??

**chevy44** · 06-21-2003, 06:08 PM

it wont hurt u to run it through ur cycle, so i would (and am) run it at 10mg/day just in case.

**OverDrive** · 06-22-2003, 04:59 PM

a little help here?

I've read sooooo many various opinions on NOT running Nolvadex unless you need it ... running it DURING the cycle ... running it AFTER the cycle WITH clomid .....

Help a brotha out

**chevy44** · 06-22-2003, 06:06 PM

i did help u out, and nolva does not hinder gains!

**OverDrive** · 06-22-2003, 07:21 PM

Chevy ... yeah bro didn't mean to exclude you I appreciate that response. Having said that ... I've read soooo many damn different opinions on the two anti-e's .. the only solid repetitive piece of advice is taking clomid 3 weeks after the cycle 300/100/50.

**kazual** · 06-22-2003, 07:43 PM

as for post cycle use clomid unless you have side effects, in that case switch to nolva. Nolva has the possibility of hindering gains when taken while on cycle, however everybody has a different level of reaction based on body chemistry. unless bloat is a concern save the nolva until needed. just my .02

***JohnnyB*** · 06-22-2003, 08:24 PM

With test E you would go 2 weeks after last injection.

Here's a study comparing nolva and clomid it might help.

Disparate effect of clomiphene and tamoxifen on pituitary gonadotropin release in vitro.

Adashi EY, Hsueh AJ, Bambino TH, Yen SS.

The direct effects of clomiphene citrate (Clomid), tamoxifen, and estradiol (E2) on the gonadotropin-releasing hormone (GnRH)-stimulated release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were studied in cultured anterior pituitary cells obtained from adult ovariectomized rats. Treatment of pituitary cells with Clomid or enclomid (10(-8) M) in vitro for 2 days resulted in a marked sensitization of the gonadotroph to GnRH as reflected by a 6.5-fold decrease in the ED50 of GnRH in terms of LH release from 2.2 x 10(-9) M in untreated cells to 3.6 x 10(-10) M. Treatment with E2 or Clomid also increased the sensitivity of the gonadotroph to GnRH in terms of FSH release by 4.3- and 3.3-fold respectively. Tamoxifen, a related antiestrogen, comparable to Clomid in terms of its ability to compete with E2 for pituitary estrogen receptors, was without effect on the GnRH-stimulated LH release at a concentration of 10(-7) M. Furthermore, tamoxifen, unlike Clomid, caused an apparent but not statistically significant inhibition of the sensitizing effect of E2 on the GnRH-stimulated release of LH. Our findings suggest that Clomid and its Enclomid isomer, unlike tamoxifen, exert a direct estrogenic rather than an antiestrogenic effect on cultured pituitary cells by enhancing the GnRH-stimulated release of gonadotropin.

JohnnyB