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  1. #1
    Breetai's Avatar
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    Estrogen is Not so much a bad thing.

    by William Llewellyn

    Can estrogen work to augment muscle growth? Is this hormone always unwanted when we are taking anabolic steroids ? Anecdotal reports from athletes suggest that the use of estrogen maintenance drugs such as tamoxifen (anti-estrogen) or aminoglutethimide (anti-aromatase) may slightly hinder muscle mass gains during steroid therapy. An explanation or even clarification for this observation has not been easy to come by. Here I would like to take a look at the comparative effectiveness of certain aromatizable and non-aromatizable drugs, as well as the possible mechanism in which estrogen can play a beneficial role to the athlete.

    The Androgen Receptor
    All anabolic/androgenic steroids promote muscle growth primarily via the cellular androgen receptor (abbreviated as AR in this article). The steroid attaches to and activates the androgen receptor, which ultimately gives the cell an order to increase protein synthesis. This process is well understood. But it has been suggested that other mechanisms may foster muscle growth during steroid therapy as well, which lie outside of the androgen receptor. One way this is evidenced is by the fact that steroids displaying a high affinity for the AR in muscle tissue do not always promote an equally high level of muscle growth. In other words, anabolic potency does not always correspond perfectly to receptor affinity. Clearly there are some disparities that lead into question whether or not the androgen receptor is the only thing at work concerning growth.

    Testosterone , Nandrolone and Methenolone
    Testosterone is without question one of the most effective steroids for building muscle mass available to athletes. However it does not have the highest affinity for the androgen receptor compared to some other steroids. For example, it has been shown that by eliminating the 19-methyl group (nandrolone) the affinity of the steroid for the androgen receptor is greatly enhanced[i]. Nandrolone thus displays approximately 2-3 times greater affinity for the androgen receptor compared to testosterone, yet its ability to promote muscle growth seems to be considerably lower than testosterone at an equal dosage. One discussed possibility for this occurrence is the reduced androgenic potency of nandrolone. While testosterone converts to the more active steroid dihydrotestosterone (3-4 times greater AR affinity) upon interaction with the 5-alpha reductase enzyme in various androgenic target tissues such as the skin, scalp, prostate, CNS and liver, nandrolone drops to a third of its original potency by converting to the weak steroid dihydronandrolone[ii]. However this action is very site specific, and in muscle tissue nandrolone dominates as the active form of the steroid. Therefore this explanation may not suffice.

    Nandrolone also differs from testosterone in its ability to be converted by the aromatase enzyme to estradiol (an active estrogen). In comparison, nandrolone aromatizes at approximately 20% of the rate testosterone does, and as such is not known as a very estrogenic steroid. It is likewise favored when reduced estrogenic side effects such as water retention, fat deposition and gynecomastia are desired. However athletes know that there is a trade off with the reduced tendency for nandrolone to promote side effects, in that it is a less anabolic steroid. With its known high affinity for the AR in muscle tissue, could this suggest that estrogen may also be a key mediator of muscle growth?

    When we look at Primobolan ® (methenolone) we see a similar trend. Methenolone is at least as good a binder of the androgen receptor as testosterone. By some accounts it is on par with nandrolone[iii]. However it is known to be much weaker than both steroids at promoting muscle growth. We know that methenolone does not interact with 5-alpha reductase, and as such its affinity for the AR does not increase or decrease in androgen target tissues. This would logically seem like a more favorable trait for anabolism over the weakening we see with nandrolone. However methenolone is a markedly weaker anabolic, and requires relatively high doses to promote growth. This also brings into question the role of 5-alpha reductase in promoting an anabolic state. Perhaps the fact that Primobolan® is a non-aromatizable steroid is more relevant.

    Estrogen and GH/IGF-1
    To date the most common explanation for why anti-estrogens may be slightly counterproductive to growth in the sports literature has been the suggestion that estrogen plays a role in the production of growth hormone and IGF-1. IGF-1 (insulin like growth factor 1, formerly known as somatomedin C) is of course an anabolic product released primarily in the liver via GH stimulus. IGF-1 is responsible for the growth promoting effects (increased nitrogen retention, cell proliferation) we associate with growth hormone therapy. We do know that women have higher levels of growth hormone than men, and also that GH secretion varies over the course of the menstrual cycle in direct correlation with estrogen levels[iv]. Estrogen is likewise often looked at as a key trigger in the release of GH in women under normal physiological situations.

    It is also suggested that the aromatization of androgens to estrogens in men plays an important role in the release and production of GH and IGF-1. This was evidenced by a 1993 study of hypogonadal men, comparing the effects of testosterone replacement therapy on GH and IGF-1 levels with and without the addition of tamoxifen[v]. When the anti-estrogen tamoxifen was given, GH and IGF-1 levels were notably suppressed, while both values were elevated with the administration of testosterone enanthate alone. Another study has shown 300mg of testosterone enanthate weekly (which elevated estradiol levels) to cause a slight IGF-1 increase in normal men, whereas 300mg weekly of nandrolone decanoate (a poor substrate for aromatase that caused a lowering of estradiol levels in this study) would not elevate IGF-1 levels[vi]. Yet another study shows that GH and IGF-1 secretion is increased with testosterone administration on males with delayed puberty, while dihydrotestosterone (non-aromatizable) seems to suppress GH and IGF-1 secretion, presumably due to its strong anti-estrogenic/gonadotropin suppressing action[vii]. All of these studies seem to support a direct, estrogen-dependant mechanism for GH and/or IGF-1 release in men. It is difficult to say at this point just how important estrogen is to IGF-1 production as it relates to the promotion of anabolism in the steroid using athlete, however it remains an interesting subject to investigate.

    Glucose Utilization and Estrogen
    Estrogen may play an even more vital role in promoting an anabolic state by affecting glucose utilization in muscle tissue. This occurs via an altering the level of available glucose 6-phosphate dehydrogenase. G6PD is an important enzyme in the support anabolism, as it is directly tied to the use of glucose for muscle growth and recuperation[viii] [ix]. During the period of regeneration after skeletal muscle damage, levels of G6PD are shown to rise dramatically. G6PD enzyme plays a vital role in what is known as the pentose phosphate pathway, and as such this rise is believed to enhance the PPP related process in which nucleic acids and lipids are synthesized in cells; fostering the repair of muscle tissue.

    A 1980 study at the University of Maryland has shown that levels of glucose 6-phosphate dehydrogenase rise after administration of testosterone propionate , and further that the aromatization of testosterone to estradiol is directly responsible for this increase.[x] In this study neither dihydrotestosterone nor fluoxymesterone could mimic the affect of testosterone propionate on levels of G6PD, an affect that was also blocked by the addition of the potent anti-aromatase 4-hydroxyandrostenedione to testosterone. 17-beta estradiol administration caused a similar increase in G6PD, which was not noticed when its inactive estrogen isomer 17-alpha estradiol (unable to bind the estrogen receptor) was given. An anti-androgen could also not block the positive action of testosterone. This study provides one of the first palatable explanations for a direct and positive effect of estrogen on muscle tissue.

    What does this all mean?
    It is a long held belief among athletes that estrogen maintenance drugs can slightly hinder muscle gains during steroid therapy with a strong aromatizable steroid such as testosterone. Whether or not we have plausibly explained this remains to be seen, however the above evidence certainly does provide strong support for a direct and positive affect of estrogen on growth. Does this mean we should abandon estrogen maintenance drugs? I don’t think that should be the case. It is important to remember that estrogen can deliver many unwanted effects such as increased water retention, fat deposition and the development of female breast tissue when it becomes too active in the male body. Clearly if we plan a high-dose cycle with an aromatizable steroid, anti-estrogens will be an important inclusion. However we cannot ignore the suggestion of using estrogen maintenance drugs only when they are necessary to combat visible side effects during mild to moderately dosed cycles, especially if bulk is the ultimate goal of the athlete.



    ill found it on the web, just wanted to share... hope it helped someone

  2. #2
    Iron_body03 is offline New Member
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    Great post Breetai, very educational.

  3. #3
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    He forgets a few things.


    1) the amount of IGF reduced by anti-es is NOT significant, remeber we are on 500-2000mg+ exengonous hormones!

    2) anti-es will NOT suppres estrogen levels any more than normal, but instead bring them where they are supposed to be! the lowest I have personally got my levels were to 20ug/dl (range 0-50)! That was even on 25mg Aromasin ED and 20mg Nolva ED

    3) the risks of having high estrogen are cerntainly NOT weighed out by having a 10-20% increase of IGF.

  4. #4
    Rickson's Avatar
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    Originally posted by Billy_Bathgate
    He forgets a few things.


    1) the amount of IGF reduced by anti-es is NOT significant, remeber we are on 500-2000mg+ exengonous hormones!

    2) anti-es will NOT suppres estrogen levels any more than normal, but instead bring them where they are supposed to be! the lowest I have personally got my levels were to 20ug/dl (range 0-50)! That was even on 25mg Aromasin ED and 20mg Nolva ED

    3) the risks of having high estrogen are cerntainly NOT weighed out by having a 10-20% increase of IGF.
    Amen. Everytime I have to read an article by Bill I always wonder why he states the obvious and yet never shows anything useful for Bodybuilders.

  5. #5
    daem's Avatar
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    i have never been a fan of his research...as billy and rickson pointed out, key facts are left out and practical application for all of us is minimal at best.

  6. #6
    The Butcher's Avatar
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    Originally posted by daem
    i have never been a fan of his research...as billy and rickson pointed out, key facts are left out and practical application for all of us is minimal at best.
    In this case, I agree with you guys, but I still stand by his post-cycle recovery regimen. It's the only one that has ever worked for me.

    Billy, it's nice to see some practical application (or should I say expiramentation) with the anti-es and how they affect your numbers. I can't recall the thread, and in fact I think it may have been Rickson that pointed this out, but since there really haven't been any studies (at least not that I have seen) that show the actual amount of reduction in estrogen that anti-es have on ones body. Since it's pretty much case-dependent, it's often just a guess as to whether 20mg of Nolva or 1mg of A-dex is needed ed, or if it's just fine to do it eod. Interesting to note that even with 20mg of Nolva/ed you didn't dip into a ridiculously low estrogen level.

  7. #7
    Breetai's Avatar
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    intressting posts guys

  8. #8
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    Very interesting read. However, I do have to tag along with Billy. The amount of IGF reduction that this article implies is nominal compared to the positive suppression of estrogen via an anti-e. My question would be; is it worth risking est complications for such a small effect on IGF levels? Just my .02

  9. #9
    Mudge is offline Junior Member
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    Quote Originally Posted by Billy_Bathgate
    3) the risks of having high estrogen are cerntainly NOT weighed out by having a 10-20% increase of IGF.
    Billy, we need your huge Anti E article while on cycle - have you finished it yet?

  10. #10
    ichabodcrane's Avatar
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    Quote Originally Posted by Billy_Bathgate
    He forgets a few things.


    1) the amount of IGF reduced by anti-es is NOT significant, remeber we are on 500-2000mg+ exengonous hormones!

    2) anti-es will NOT suppres estrogen levels any more than normal, but instead bring them where they are supposed to be! the lowest I have personally got my levels were to 20ug/dl (range 0-50)! That was even on 25mg Aromasin ED and 20mg Nolva ED

    3) the risks of having high estrogen are cerntainly NOT weighed out by having a 10-20% increase of IGF.
    But don't everyone forget the positive effects brought on by having some degree of estrogen levels present, ie. "the heart happy effects". It is not all bad, and in fact can prove beneficial over time, especially for those running longer cycles. I am a firm believer in not decreasing estrogen levels as much as possible, but rather doing so if they are not tolerated.

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