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Thread: Chemistry of Testosterone enanthate

  1. #1
    BrockBadger is online now Junior Member
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    Chemistry of Testosterone enanthate

    Hi there,

    I'm just curious of how the chemical structure of testosterone enanthate is? If someone could describe it in terms of hydrogen etc that would be great.

  2. #2
    jstone is offline Knowledgeable Member
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    Just google testosterone enanthate and you will find all the info you need.
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  3. #3
    BrockBadger is online now Junior Member
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    I'm not too good with chemistry. Looks like C26H40O3. Got this from wikipedia. I'm not sure of the bonding. Which are hydrogen and which are covalent bonds? I would assume covalent but am not sure how the structure operates. Why is the shape that it is? And how does this molecule fit into where in the human body for men?

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    Kidding?

    First it follows a standard "steroid skeleton" ring structure,
    4 rings where 3 are 6C rings, and one is a 5C ring.
    (None of the rings are aromatic, unless when T is converted to estradiol and the A ring becomes aromatic.

    While there are some double bonds in the testosterone molecule,
    it's mostly single bonds. Covalent bonds... fuck it.
    Google it.

    And the enanthate ester is attached at the C17 carbon (in a beta configuration)
    It has to be removed for the testosterone to become active.
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  5. #5
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    And it is derived from cholesterol, so naturally it's gonna look pretty similar.
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    Quote Originally Posted by DocToxin8 View Post
    Kidding?

    While there are some double bonds in the testosterone molecule,
    it's mostly single bonds. Covalent bonds... fuck it. Google it.

    Cracked me up doc.
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    Quote Originally Posted by BrockBadger View Post
    I'm not too good with chemistry. Looks like C26H40O3. Got this from wikipedia. I'm not sure of the bonding. Which are hydrogen and which are covalent bonds? I would assume covalent but am not sure how the structure operates. Why is the shape that it is? And how does this molecule fit into where in the human body for men?
    Then why the question regarding the chemical structure?
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  8. #8
    BrockBadger is online now Junior Member
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    Quote Originally Posted by DocToxin8 View Post
    Kidding?

    First it follows a standard "steroid skeleton" ring structure,
    4 rings where 3 are 6C rings, and one is a 5C ring.
    (None of the rings are aromatic, unless when T is converted to estradiol and the A ring becomes aromatic.

    While there are some double bonds in the testosterone molecule,
    it's mostly single bonds. Covalent bonds... fuck it.
    Google it.

    And the enanthate ester is attached at the C17 carbon (in a beta configuration)
    It has to be removed for the testosterone to become active.
    No I'm not kidding. I genuinely appreciate the response on this. I feel like I should be more educated on a tough topic like this. So, far I see the 4 rings. 3 are 6C. Does 6C mean cyclohexane? I think this is correct. And the 5C ring is cyclopentane? Got ya, most are covalent single bonds. It looks like enanthate ester is the part thats not attached to the ring structure in the diagram? Is the A ring the first ring where the oxygen is attached it looks like?
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  9. #9
    BrockBadger is online now Junior Member
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    Quote Originally Posted by Sicko View Post
    Then why the question regarding the chemical structure?
    It's good to be informed.

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    BrockBadger is online now Junior Member
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    Well thats ok we got some of it out of the way.

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    Its quite simple structurally. It has atoms of different shit, chemical bonds, some shit about rings as doc said, molecule... carbons and such...
    Other fancy words...

    The interesting part is whe you jam it into your receptors and lift heavy objects.

    Sorry to be so scientific, I know I am throwing a lot at you at once. You may have to read this a few times before you fully understand.

    Do not forget that part about jamming it into your receptors! This is vital info!

    You are welcome sir!

  12. #12
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    Quote Originally Posted by BrockBadger View Post
    No I'm not kidding. I genuinely appreciate the response on this. I feel like I should be more educated on a tough topic like this. So, far I see the 4 rings. 3 are 6C. Does 6C mean cyclohexane? I think this is correct. And the 5C ring is cyclopentane? Got ya, most are covalent single bonds. It looks like enanthate ester is the part thats not attached to the ring structure in the diagram? Is the A ring the first ring where the oxygen is attached it looks like?
    Ok, ok, I'm late to the party here but I'll add in as an afterthought;
    Understanding the chemical structure of test ain't gonna help you none regarding its effects in the body, there are some generalizations that can be made though. Like aromatic A rings and estrogen receptor affinity, double bonds in the B ring and androgenic potential and so on,
    but that's really vague shit really.

    But I'll explain a bit further;
    Yes the 6C rings are cyclohexane rings, and the 5C ring a cyclopentene ring.
    Doesn't really tell you anything at all; except that means it's a steroid ;
    All steroids follow this rule as a skeleton frame.

    The Oxygen atom is in the A ring, and is a ketone in testosterone ; a double bond, while it's a single bond to it thus being a hydroxyl group (OH) in estrogen.
    The D ring is were the enanathate or any fatty acid is attached,
    Or a methyl group is placed in "oral" steroids. (C17 methylated)

    All this doesn't really mean jack shit at this level of chemistry though,
    but I figure learning is always a good thing.
    Just DO NOT extract any knowledge from this that isn't there.
    L
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    Quote Originally Posted by BrockBadger View Post
    Hi there,

    I'm just curious of how the chemical structure of testosterone enanthate is? If someone could describe it in terms of hydrogen etc that would be great.
    If you're "not to good with chemistry" what does this matter to you? Please don't take this as me being a jerk, as it is a legitimate question. I did chuckle a little bit, I'm not going to lie. But I don't want to come off as a jerk because I really am not one.

  14. #14
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    You don't come across as a jerk PT, never seen you do actually.
    And my bad for answering an old thread, I've been away for the summer;
    (Code; I drank heavily and lost my bearings, and ended up in Ireland)
    and someone had liked my response so I clicked and responded further.

    The OP is probably long gone.
    Nice to "see" you btw!

  15. #15
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    Quote Originally Posted by DocToxin8 View Post
    You don't come across as a jerk PT, never seen you do actually.
    And my bad for answering an old thread, I've been away for the summer;
    (Code; I drank heavily and lost my bearings, and ended up in Ireland)
    and someone had liked my response so I clicked and responded further.

    The OP is probably long gone.
    Nice to "see" you btw!
    Thanks buddy! When I was asking the OP as to why he was wondering the chemistry behind test e, I thought it might have came across as a smart a$$ comment. But it does perplex me as to why the question was asked. Lol. And the post isn't very old. I'm glad you bumped it so I could see it!
    It is great to be back. I know that. I'm still not in the gym yet, as my current health issues aren't fixed, but I'm getting there. Slowly but surely. I have 6 weeks of physical therapy scheduled and an appointment with a rheumatologist. Once it's all figured out, I'm going to run a BIG, fat blast and hammer down in the gym to make up for these lost 6 months! Lol
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  16. #16
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    Quote Originally Posted by DocToxin8 View Post
    Ok, ok, I'm late to the party here but I'll add in as an afterthought;
    Understanding the chemical structure of test ain't gonna help you none regarding its effects in the body, there are some generalizations that can be made though. Like aromatic A rings and estrogen receptor affinity, double bonds in the B ring and androgenic potential and so on,
    but that's really vague shit really.

    But I'll explain a bit further;
    Yes the 6C rings are cyclohexane rings, and the 5C ring a cyclopentene ring.
    Doesn't really tell you anything at all; except that means it's a steroid ;
    All steroids follow this rule as a skeleton frame.

    The Oxygen atom is in the A ring, and is a ketone in testosterone ; a double bond, while it's a single bond to it thus being a hydroxyl group (OH) in estrogen.
    The D ring is were the enanathate or any fatty acid is attached,
    Or a methyl group is placed in "oral" steroids. (C17 methylated)

    All this doesn't really mean jack shit at this level of chemistry though,
    but I figure learning is always a good thing.
    Just DO NOT extract any knowledge from this that isn't there.
    L

    I'm just hoping there's not a test at the end of this thread.....
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    Quote Originally Posted by kelkel View Post
    I'm just hoping there's not a test at the end of this thread.....
    Can you believe Doc is a "knowledgable member"
    I mean really...
    What a flunky.
    My explanation was way more in depth.
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  18. #18
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    Quote Originally Posted by DocToxin8 View Post
    Ok, ok, I'm late to the party here but I'll add in as an afterthought;
    Understanding the chemical structure of test ain't gonna help you none regarding its effects in the body, there are some generalizations that can be made though. Like aromatic A rings and estrogen receptor affinity, double bonds in the B ring and androgenic potential and so on,
    but that's really vague shit really.

    But I'll explain a bit further;
    Yes the 6C rings are cyclohexane rings, and the 5C ring a cyclopentene ring.
    Doesn't really tell you anything at all; except that means it's a steroid ;
    All steroids follow this rule as a skeleton frame.

    The Oxygen atom is in the A ring, and is a ketone in testosterone ; a double bond, while it's a single bond to it thus being a hydroxyl group (OH) in estrogen.
    The D ring is were the enanathate or any fatty acid is attached,
    Or a methyl group is placed in "oral" steroids. (C17 methylated)

    All this doesn't really mean jack shit at this level of chemistry though,
    but I figure learning is always a good thing.
    Just DO NOT extract any knowledge from this that isn't there.
    L
    You lost me at A rings...My mind instantly went to those chewy green & white apple flavored gummy candy.
    Impressive though.
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  19. #19
    BrockBadger is online now Junior Member
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    Quote Originally Posted by DocToxin8 View Post
    Ok, ok, I'm late to the party here but I'll add in as an afterthought;
    Understanding the chemical structure of test ain't gonna help you none regarding its effects in the body, there are some generalizations that can be made though. Like aromatic A rings and estrogen receptor affinity, double bonds in the B ring and androgenic potential and so on,
    but that's really vague shit really.

    But I'll explain a bit further;
    Yes the 6C rings are cyclohexane rings, and the 5C ring a cyclopentene ring.
    Doesn't really tell you anything at all; except that means it's a steroid ;
    All steroids follow this rule as a skeleton frame.

    The Oxygen atom is in the A ring, and is a ketone in testosterone ; a double bond, while it's a single bond to it thus being a hydroxyl group (OH) in estrogen.
    The D ring is were the enanathate or any fatty acid is attached,
    Or a methyl group is placed in "oral" steroids. (C17 methylated)

    All this doesn't really mean jack shit at this level of chemistry though,
    but I figure learning is always a good thing.
    Just DO NOT extract any knowledge from this that isn't there.
    L

    Nice way cool. Let me look over this in more detail it's explained pretty clear. There will be a test at the end of this. I thought this thread was going to die but I'm back.
    Last edited by BrockBadger; 08-25-2017 at 08:52 PM.

  20. #20
    BrockBadger is online now Junior Member
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    Quote Originally Posted by PT1982 View Post
    If you're "not to good with chemistry" what does this matter to you? Please don't take this as me being a jerk, as it is a legitimate question. I did chuckle a little bit, I'm not going to lie. But I don't want to come off as a jerk because I really am not one.
    I admire chemistry. That is the reason. Were you always good at weight lifting? Maybe I'm not good at it but just like it. You guys thought I just bailed out on the thread huh.
    Last edited by BrockBadger; 08-25-2017 at 08:58 PM.

  21. #21
    Couchlockd's Avatar
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    He wants a test tattoo...

  22. #22
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    Quote Originally Posted by obspowerstroke View Post
    its quite simple structurally. It has atoms of different shit, chemical bonds, some shit about rings as doc said, molecule... Carbons and such...
    Other fancy words...

    The interesting part is whe you jam it into your receptors and lift heavy objects.

    Sorry to be so scientific, i know i am throwing a lot at you at once. You may have to read this a few times before you fully understand.

    Do not forget that part about jamming it into your receptors! This is vital info!

    You are welcome sir!
    awesome!

  23. #23
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    Prediction of next post by BadBadger:
    "During gyno surgery, the doctor promised to cut my heart out. I don't think I'll need it. What would be the ramifications?"
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  24. #24
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    Just google "steroid skeleton" and you'll get an explanation of what we call ;
    A, B, C and D rings. It's just nomenclature since there's 4 rings in a steroid skeleton.

    Now that's something a steroid only mean that it has this skeleton structure.
    So examples of steroids can be;
    -cholesterol (from which the body makes other steroids)
    -testosterone (and other androgens)
    -estrogen (all natural estrogens have a steroid skeleton,
    you then got phytosteroids from plants, and you got chemicals with "steroid-like" effects, f.ex estrogen mimickers. These does not need to have steroid skeleton.
    -cortisol and other glucocorticoids; inflammation and blood sugar, etc
    -mineralcorticoids; affect the kidneys, blood pressure

    So a "steroid" can mean quite a lot.

    In medicine, the term "steroid" applies to glucocorticoids like cortisol (or its pre drug cortisone),
    while you'd say "anabolic (androgenic ) steroid" if you mean AAS.
    or simply "sex steroids" for estrogens, progesterone, androgens..

    If you delve into chemistry you can sometimes say some very general stuff just from looking at the structure, but will often be suprised.
    But an aromatic A ring would make me think "that looks estrogenic"
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  25. #25
    BrockBadger is online now Junior Member
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    Quote Originally Posted by Couchlockd View Post
    He wants a test tattoo...
    Yeah, I'm kind of a testosterone worshipper.

  26. #26
    charger69 is online now Member
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    Quote Originally Posted by Obspowerstroke View Post
    Can you believe Doc is a "knowledgable member"
    I mean really...
    What a flunky.
    My explanation was way more in depth.
    I agree Obs- no disrespect Doc. LOL
    I wish that I had teachers like you.
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  27. #27
    Nogbad the bad is offline Associate Member
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    I had a chemistry set,when i was a kid,but once i'd learned to make stink bombs,my interest waned.

  28. #28
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    Quote Originally Posted by charger69 View Post
    I agree Obs- no disrespect Doc. LOL
    I wish that I had teachers like you.
    We will learn him.
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  29. #29
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    Quote Originally Posted by Nogbad the bad View Post
    I had a chemistry set,when i was a kid,but once i'd learned to make stink bombs,my interest waned.
    Wrap a ping pong ball in tinfoil. Wrap it such that you get a handle of sorts on one side, the tinfoil right around the ball.
    Ignite lighter 2 cms under ball while holding the tinfoil handle,
    do not come close to where the tinfoil is just a thin layer over the ball.

    Hold lighter ignited for about 10-30sec,
    when it's say "pssshhhhhhh" and smoke bellows out throw it. (Not cool to throw into somebody's house, shit is toxic.)
    Easy peasy.

    (And if you feel one doesn't give enough bang,
    be inventive: they are very small after all)
    Last edited by DocToxin8; 09-02-2017 at 03:15 PM.

  30. #30
    charger69 is online now Member
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    Quote Originally Posted by DocToxin8 View Post
    Wrap a ping pong ball in tinfoil. Wrap it such that you get a handle of sorts on one side, the tinfoil right around the ball.
    Ignite lighter 2 cms under ball while holding the tinfoil handle,
    do not come close to where the tinfoil is just a thin layer over the ball.

    Hold lighter ignited for about 10-30sec,
    when it's say "pssshhhhhhh" and smoke bellows out throw it. (Not cool to throw into somebody's house, shit is toxic.)
    Easy peasy.

    (And if you feel one doesn't give enough bang,
    be inventive: they are very small after all)
    Come on doc...... don't provoke Obs.


    Sent from my iPhone using Tapatalk
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  31. #31
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    Quote Originally Posted by charger69 View Post
    Come on doc...... don't provoke Obs.


    Sent from my iPhone using Tapatalk
    Lol its too late

  32. #32
    BrockBadger is online now Junior Member
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    Quote Originally Posted by DocToxin8 View Post
    Just google "steroid skeleton" and you'll get an explanation of what we call ;
    A, B, C and D rings. It's just nomenclature since there's 4 rings in a steroid skeleton.

    Now that's something a steroid only mean that it has this skeleton structure.
    So examples of steroids can be;
    -cholesterol (from which the body makes other steroids)
    -testosterone (and other androgens)
    -estrogen (all natural estrogens have a steroid skeleton,
    you then got phytosteroids from plants, and you got chemicals with "steroid-like" effects, f.ex estrogen mimickers. These does not need to have steroid skeleton.
    -cortisol and other glucocorticoids; inflammation and blood sugar, etc
    -mineralcorticoids; affect the kidneys, blood pressure

    So a "steroid" can mean quite a lot.

    In medicine, the term "steroid" applies to glucocorticoids like cortisol (or its pre drug cortisone),
    while you'd say "anabolic (androgenic ) steroid" if you mean AAS.
    or simply "sex steroids" for estrogens, progesterone, androgens..

    If you delve into chemistry you can sometimes say some very general stuff just from looking at the structure, but will often be suprised.
    But an aromatic A ring would make me think "that looks estrogenic"
    I understand the chemistry so far of your knowledge... very Cool

    Speaking of jamming the testosterone into the receptors. How is this molecule used in the body? Where does it bind to or which receptors does it attach. Basically, how is the molecule used by the body.

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    This a really cool graphic that explains how chemists modified testosterone to make all the derivatives we see on the market. Many steroids and prohormones start as test, and then are modified by one or more of these ways. For example, 19-nor steroids like Deca and tren, all remove the angular methyl group(carbon 19). All orals add an alpha methyl group on 17 to enhance bioavailability. Both EQ and Dbol add a double bond between carbon 1-2. Stanazolol attaches a pyrazole ring to the A-ring. Halodrol added a chlorine atom to carbon 4 to protect against conversion to DHT. All injectables add an ester on the OH in carbon 17 to change the delivery time. Attaching a 7alpha methyl group has been shown to greatly enhance anabolic ratio. Superdrol and anadrol add a group to carbon 2 to help protect the crucial C=O on carbon 3 needed for binding. Trestolone added the 7a methyl group to prevent DHT and SHBG binding. There are literally 100s of modifications you can make to change the effects by changing the binding affinity to the AR. I just thought this was cool and maybe can give a little insight on why certain anabolics act the way they do in the body.


    REF: https://www.instagram.com/p/BYZHgYEjWRz/?hl=en

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    BrockBadger is online now Junior Member
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    Quote Originally Posted by tarmyg View Post
    Good one. These are the modifications to the testosterone molecule. I don't know what "AR" means. And what if I just want to know how the testosterone with no modifications is used in the body, what it binds to, how it works. This is a pretty cool pic though and description. Way to go tarmyg.

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    Quote Originally Posted by BrockBadger View Post
    Good one. These are the modifications to the testosterone molecule. I don't know what "AR" means. And what if I just want to know how the testosterone with no modifications is used in the body, what it binds to, how it works. This is a pretty cool pic though and description. Way to go tarmyg.
    dude... testosterone is a natural occuring hormone inthe body. if u wanna know how it works, then id recommend a book. "Testosterone: Action, Deficiency, Substitution". explains all u want to know..
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    Quote Originally Posted by Lemonada8 View Post
    dude... testosterone is a natural occuring hormone inthe body. if u wanna know how it works, then id recommend a book. "Testosterone: Action, Deficiency, Substitution". explains all u want to know..
    Well look who showed up!

    Op, another book of interest would be Testosterone for Life by Abraham Morgantaler. He's probably the top doc in the country when it comes to understanding testosterone. He's been researching it for about 40 years.
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  37. #37
    BrockBadger is online now Junior Member
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    Ok guys that sounds good. I'll check those books out. But I definitely want to hear what Doctoxin has to say. He is very clear in his explanation. Plus its fun.

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