07-14-2003, 07:09 AM #1
Simple question- what's the half life of nolva?
What's nolva's half-life?
I'm using 10mg EOD along with Aromasin E3D throughout my cycle to control estrogen. I just want to make sure that by using nolva EOD instead of ED i'm not causing my estrogen levels to bounce around.
07-14-2003, 07:42 AM #2
I got this info from here:
After oral administration, tamoxifen is absorbed rapidly with maximum serum concentrations attained within 4 to 7 hours. Steady state concentrations (about 300 nanogram/mL) are achieved after four weeks treatment with 40mg daily. The medicine is highly protein bound to serum albumin (>99%). Metabolism is by hydroxylation, demethylation and conjugation, giving rise to several metabolites which have a similar pharmacological profile to the parent compound and thus contribute to the therapeutic effect. Excretion occurs primarily via the faeces and an elimination half-life of approximately seven days has been calculated for the medicine itself, whereas that for N-desmethyltamoxifen, the principal circulating metabolite, is 14 days.
07-21-2003, 12:51 PM #3
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