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  1. #1
    Rickson's Avatar
    Rickson is offline AR-Hall of Famer
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    Jul 2002

    A look at effects of test and deca on Muscle and Bone Density

    Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment.

    Crawford BA, Liu PY, Kean MT, Bleasel JF, Handelsman DJ.

    Department of Endocrinology, ANZAC Research Institute, Royal Prince Alfred Hospital and University of Sydney, Sydney, New South Wales, Australia.

    Long-term glucocorticoid therapy in men is associated with loss of bone and muscle mass as well as a decrease in serum testosterone . We tested the effect of two androgens, testosterone and its minimally aromatizable analog nandrolone , on muscle mass (dual x-ray absorptiometry), muscle strength (knee flexion and extension by isokinetic dynamometry), bone mineral density (BMD), and quality of life (Qualeffo-41 questionnaire) in 51 men on a mean daily prednisone dose of 12.6 +/- 2.2 mg. Men were randomized, double blind, to testosterone (200 mg mixed esters), nandrolone decanoate (200 mg), or placebo given every fortnight by im injection for 12 months. At 12 months, both androgens increased muscle mass (mean change from baseline +3.5%, +5.8%, and -0.9% in testosterone, nandrolone, and placebo groups, respectively, P < 0.0001) and muscle strength (P < 0.05). Lumbar spine BMD increased significantly only in men treated with testosterone (4.7 +/- 1.1%, P < 0.01). There was no significant change in hip or total body BMD. Testosterone, but not nandrolone or placebo, improved overall quality of life (P < 0.001). These results suggest that androgen therapy may have a role in ameliorating adverse effects of glucocorticoid therapy such as muscle and bone loss and aromatization is necessary for androgen action on bone but not on muscle.

    Publication Types:
    Clinical Trial
    Randomized Controlled Trial

  2. #2
    Rookiejay's Avatar
    Rookiejay is offline Member
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    Jul 2003
    They were getting 100 mg / week (200mg eow) for 12 months - that's a hell of a long cycle - I wonder if they did PCT?

    So Deca patients got more muscle....
    Test patiens got some muscles and improved their quality of life.....

    Uh, sometimes my life sucks - I think I'll add some more test to my cycle........

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