Thread: Anti-E Confusion PLEASE help!
02-29-2004, 12:50 PM #1
Anti-E Confusion PLEASE help!
Which is worse on your blood lipid profile Arimidex or Femera? I have had numerous ppl tell me that it was Arimidex on another board yet Im almost positive that I read femera was the one to blame for the effect it has on your lipids.
Does anybody know? If you could pease post a reference or study. It would be very much appreciated as it would shut some of those guys up (or me )
02-29-2004, 12:58 PM #2
this was posted by pheedno.. i always look for his posts when it comes to things like this....
The study on this:
Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer.
Dowsett M, Pfister C, Johnston SR, Miles DW, Houston SJ, Verbeek JA, Gundacker H, Sioufi A, Smith IE.
Department of Biochemistry, Royal Marsden Hospital, London, United Kingdom.
This study examined whether the addition of tamoxifen to the treatment regimen of patients with advanced breast cancer being treated with the aromatase inhibitor letrozole led to any pharmacokinetic or pharmacodynamic interaction. Twelve of 17 patients completed the core period of the trial in which 2.5 mg/day letrozole was administered alone for 6 weeks and in combination with 20 mg/day tamoxifen for the subsequent 6 weeks. Patients responding to treatment continued on the combination until progression of disease or any other reason for discontinuation. Plasma levels of letrozole were measured at the end of the 6-week periods of treatment with letrozole alone and the combination and once more between 4 and 8 months on combination therapy. No further measurements were done thereafter. Hormone levels were measured at 2-week intervals throughout the core period. Marked suppression of estradiol, estrone, and estrone sulfate occurred with letrozole treatment, and this was not significantly affected by the addition of tamoxifen. However, plasma levels of letrozole were reduced by a mean 37.6% during combination therapy (P<0.0001), and this reduction persisted after 4-8 months of combination therapy. Letrozole is the first drug to be described in which this pharmacokinetic interaction occurs with tamoxifen. The mechanism is likely to be a consequence of an induction of letrozole-metabolizing enzymes by tamoxifen but was not further addressed in this study. It is possible that the antitumor efficacy of letrozole may be affected. Thus, sequential therapy may be preferable with these two drugs. It is not known whether tamoxifen interacts with other members of this class of drugs or with other drugs in combination.
02-29-2004, 01:02 PM #3
Also posted by pheedno Use L-dex and Nolva(.25mg + 10mg)
Femara not only has stronger adverse effects on lipids than L-dex, but it also cannot be used in conjunction with Nolva, and a SERM should be used throughout
hope this helps Bro
02-29-2004, 01:07 PM #4Originally Posted by powerlifter
Actually correction. Femara can be used with Nolva, but you'll see a reduction in femara blood plasma level. The percentage will rely on Nolva dosing, but 20mg has been shown to produce a 37.6% drop
02-29-2004, 01:09 PM #5Originally Posted by razor67
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