Thread: Nolvadex or Proviron
04-02-2004, 08:43 AM #1
04-02-2004, 09:04 AM #2
Well, that's a tricky answer, they're different.
If money was "no issue" I would run them both.
Nolva is an ER Blocker, and Proviron is basically an Androgen (I think it's half Viagra if ya ask me!)
04-02-2004, 12:15 PM #3
04-02-2004, 01:12 PM #4Originally Posted by SaTyR
Nolva is an ER Blocker, Proviron is an Estrogen Antagonist.
Nolva Blocks, where Proviron eliminates the aromatisation all together (theoretically)
Therfore, with Proviron, Gyno and Water retention never get a start, as where Nolva let's it start, then Blocks it.
Also, Proviron will give you a hard look if ran high enough (maybe 50mg ED), you won't get that effect from Nolva obviously.
Nolva has the "possibility" of rebounding somewhat, sincce it does allow aromitization to take place, where as Proviron does not.
This is the best I can do not knowing exactly what you want to know about the drugs...hope this helps.
04-02-2004, 05:54 PM #5Registered User
- Join Date
- Dec 2002
Iam running both, and have not gained any water-weight, good combo IMO
04-02-2004, 06:15 PM #6
I like provirion. It prevents test from converting to estrogen whereas Nolva just blocks estrogen from binding to receptors. Because of that you have more test in your body at any given time if you use provirion. Also since it is an androgen, Provirion has the capacity to give your muscles that dense look and feel. It will also help keep lead in your "pencil" if you are running other compounds besides test.
04-02-2004, 06:31 PM #7Originally Posted by SGFuryZ
04-03-2004, 01:21 AM #8Originally Posted by TheSevnthWarrior
04-03-2004, 08:26 AM #9
I think that Proviron can affect your lipids (cholesterol), but I'm not sure. Femara is what I would go with, but I think Proviron is better than Nolva. Everyone has their own personal preference. As long as you are taking SOME kind of anti-e, you should be set. Search through Phedno's old posts on anti-e. He knows all about the topic, and the info is out there to be found (I think it's one of my old threads).
04-03-2004, 10:42 AM #10Originally Posted by SaTyR
04-03-2004, 10:52 AM #11
Proviron will have, assumedly, similar actions to DHT, considering the similar structure. This is the only paper I've ever been able to find to actually even imply proviron may be an AI.
J Clin Endocrinol Metab. 1984 Mar;58(3):467-72. Related Articles, Links
The intracellular control of aromatase activity by 5 alpha-reduced androgens in human breast carcinoma cells in culture.
Perel E, Stolee KH, Kharlip L, Blackstein ME, Killinger DW.
Four cell lines, each derived from a primary tumor from a patient with breast carcinoma, were grown to confluence in alpha-Minimum Essential Medium with 15% fetal calf serum and incubated for 24 h with [3H]androstenedione. The two lines (SA and PP) with the lowest formation of estrone and estradiol (less than 0.1% conversion) were the most active in the formation of the 5 alpha-reduced androgen metabolites androsterone (AND), 5 alpha-androstanedione (5 alpha-A-dione), and dihydrotestosterone (DHT). The two lines with the highest aromatase activity (DM and MD) had the lowest formation of 5 alpha-reduced metabolites. To determine if the 5 alpha-reduced androgen metabolites formed within the breast carcinoma cells could influence aromatase activity, the MD line was further studied. After 24-h preincubation with AND, DHT, or 5 alpha-A-dione at concentrations of 10(-6), 10(-7), and 10(-8) M, [3H]androstenedione was added to the culture medium, and aliquots were removed at 0, 4, 8, and 24 h. An 8-h incubation period was found to be optimum for inhibition studies. In comparison to control levels of estrone (2.5%) and estradiol (0.35%) formation, inhibition of aromatization was evident with all three compounds at 10(-8) M, with 5 alpha-A-dione producing the greatest inhibition (50%). At 10(-7) M, inhibition ranged from 45% (AND) to 70% (5 alpha-A-dione), and at 10(-6) M, inhibition was greater than 90% for each compound. 5 alpha-A-dione produced slightly greater inhibition than AND or DHT at each concentration tested. Since each of these compounds was capable of inhibiting aromatization, the cumulative effect of these 5 alpha-reduced metabolites could be an important factor in the intracellular regulation of aromatase activity.
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