Lets Forget AR
10-12-2005, 11:37 PM
Omnadren
(Testosterone)
[4-androsten-3-one-17beta-ol]
17beta-hydroxy-androst-4-en-3-one
Molecular Weight (of Base): 288.429
Molecular Weight (esters)
Propionate: 362.5082
Phenylpropionate: 438.6058
Isocaproate: 404.5886
Caproate:116.16
Formula (of Base): C19 H28 O2
Formula (esters)
Propionate:C3 H6 O2
Phenylpropionate:C9 H10 O2
Isocaproate:C6 H12 O2
Caproate:C16 H12 O2
Melting Point: 154-155C
Manufacturer: Jelfa
Effective dose: 250-1,000mgs/week
Active Life: 10 days
Detection Time: 3 months
Anabolic/Androgenic Ratio: 100:100
1 milliliter of Omnadren 250 contains:
30mg testosterone propionate
60mg testosterone phenylpropionate
60mg testosterone isocaproate
100mg testosterone caproate
Omnadren 250 is a combination of the 4 separate test esters listed above.
Older versions of the drug list the final two esters as ‘isohexanoate’
and ‘hexanoate.’ However, it should be noted that hexanoate is simply
another word for caproate so the drug’s esters have not actually been
modified. Most commonly, people will correlate Omnadren 250 with its
cousin Sustanon 250, since they are both a blend of 4 test esters. The
only difference between the two lies in the last –and most concentrated-
ester. Whilst Omnadren contains the caproate ester, Sustanon contains the
decanoate ester in the same concentration. Really, except for price, there’s no difference…and price-wise, you’re going to be paying ½ as much for Omnadren as you would for Sustanon (or $3-4usd/amp). This is a very nice price, and for that reason, I typically advise people to purchase Omnadren over Sustanon, if their source carries it.
It is also not uncommon to hear people refer to Omnadren as a superior version
of testosterone since it boasts 4 esters instead of 1 (or none). This
should be taken with a grain of salt. All testosterone’s produce very
similar effects while the ester simply delays the release of
the compound into the body which has two immediate consequences. The first
being less important; injection frequency. This has become a hotly debated
issue recently… on the one side are those who advocate injections only
once or twice per week. Frequently their arguments are supported with
cycle results which have yielded ‘good gains.’ On the other side –and
perhaps the more scientific side- are those who advocate injections at
least every other day (EOD) or ever day (ED). One has only to glance at
the ester constitution in Omnadren to understand why this may be . Such
small concentrations of the shorter esters (propionate and
phenylpropionate) are rendered practically useless when Omnadren is
injected once or twice per week. Furthermore, when injecting only a few
times per week the ‘peaks and valleys’ of concentration in the blood are
not desirable. We want our blood concentration of the drugs to be as high
as they can be –relative to dose- as long as they can be. Obviously, this
is not the case when fast acting esters are introduced and subsequently
dissipated before another injection is given.
As the longest ester in Omnadren (caproate) is slightly faster acting than the
longest ester in Sustanon (decanoate), users will notice an increase in
their testosterone levels sooner with Omnadren than with Sustanon. This
has a few consequences which we shall examine now. First of all, since
testosterone aromatizes (converts) to estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42), a buildup of this female
hormone will occur more rapidly. With estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42) increase follows the
inevitability of increased water retention. This is significant for 3
reasons: First, the user’s strength will increase. Secondly, the user’s
size will increase, and finally, definition in the muscles will begin to
dissipate. As an obvious result, Omnadren is typically used more for
bulking than cutting. The extent of these effects are highly dictated by
the user’s diet and training habits, although it is also easily controlled
with the proper use of anti-estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42) drugs such as Nolvadex (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=43), Armidex, Proviron, and a myriad of others.
As I previously stated, testosterone is a highly anabolic and androgenic hormone, it has an anabolic (muscle building) rating of 100, making it a good drug to use if one is in pursuit of more size and strength. And if you aren’t in pursuit of more size and strength, then why would you be reading this, right? Well, let’s get on with it and look at exactly what makes testosterone a good mass builder. Firstly, testosterone promotes nitrogen retention in the muscle(6) the more nitrogen the muscles holds the more protein (http://www.allsportsnutrition.com/) the muscle stores. Testosterone can also increase the levels of the highly anabolic hormone, IGF-1, in muscle tissue(7)(9). Even the aromatized part of testosterone that turns into estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42) may increase levels of IGF, and sensitivity to it. Testosterone’s actions come mostly from it’s binding to the androgen receptor to promote A.R dependant mechanisms for both muscle gain and fat (http://www.allsportsnutrition.com/) loss (5). Thankfully, it also significantly increases the concentrations of the A. R in cells critical for muscle repair and growth and A.R in muscle(8 ). Testosterone induces changes in shape, size and also can change the appearance and the number of muscle fibers(7). Androgens like the testosterone(s) found in Omnadren can protect your hard earned muscle from the catabolic hormones(8), whether those hormones occur from exercise or other stress.
There are strong androgenic side effects, which are pronounced with
Omnadren (as with all testosterones). Oily skin, acne, increased body/facial hair, and depending on the individual an increase in aggressiveness can
occur. Omnadren can also be hard on the hairline. This is partly due to
the conversion of the testosterone into dihydrotestosterone (DHT). Test is
converted to DHT via the 5-alpha reductase enzyme. While DHT is more
potent than test at the androgen receptor (the double bond is removed from
the carbon4-carbon5 bond and replaced with a hydrogen atom on each)
and is responsible for some growth. It can also cause some negative side
effects as well. Testosterone, because of this bond is actually much more anabolic, in practical terms, because it For example: DHT formation in the scalp is suspected of
causing/expediting male pattern baldness. To possibly combat this, one can
use finasteride (Proscar (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=44)®). This drug will inhibit the conversion of
testosterone to DHT but many users will report that since DHT is more
potent at the androgen receptor than test, gains in muscle mass as well as
strength will diminish. On the other hand, a lack of DHT caused by blocking 5-AR can sometimes cause gynocomastia (4)(5).
Typically cycles which contain Omnadren 250 will be around 12-16
weeks. The idea is that it will take at least 2 weeks for the compound to
become fully ‘active’ in the body, and most users will report an
additional 1-3 weeks until the effects of Omnadren are truly felt. As a
result, gains from Omnadren are not typically noticed for about 1 month
after the first injection. What most people mean by this is that although the actual drug is already active, gains aren’t realized immediately. The majority of users willsupplement a fast acting oral drug such as Dianabol or Anadrol in the first 4 weeks of a
cycle which is thought of as a ‘kickstart’ until the effects of the
Omnadren are fully felt. As mentioned above a typical weekly dose of
Omnadren can range from 500mg-1000mg per week. Those who are new to
steroids and cycling should generally start with a minimal dose so as to better
judge how their own bodies will react to the synthetic testosterone. I’d suggest beginners sitck with 2 amps per week, if they’re inclined to use this preparation.
Omnadren has always been manufactured by Polfa© which has since changed
their name to Jelfa©. The company is based in Poland, and as one might
obviously conclude, the availability and price of Omnadren 250 there is
much different than many other places. Often, fake Sustanon in the 80’s would actually turn out to be Omnadren, which was much less highly prized (nonsensically).
References:
1. Hypothalamic sites of action for testosterone, dihydrotestosterone, and estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42) in the regulation of luteinizing hormone secretion in male sheep. Endocrinology. 1997 Sep;138(9):3686-94.
2. Inhibition of LH Secretion by Localized Administration of Estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42), but not Dihydrotestosterone, Is Enhanced in the Ventromedial Hypothalamus During Feed Restriction in the Young Wether.
Biol Reprod. 2005 Jun 22; [Epub ahead of print]
3. Crystalline dihydrotestosterone implants in the lateral septum of male rats. A positive effect on LH and FSH.
Endocr Res. 2001 Feb-May;27(1-2):35-40.
4. Significant role of 5 alpha-reductase on feedback effects of androgen in rat anterior pituitary cells demonstrated with a nonsteroidal 5 alpha-reductase inhibitor ONO-3805. J Androl. 1994 Nov-Dec;15(6):521-7.
5. Case report: finasteride-induced gynecomastia in a 62-year-old man.
Am J Med Sci. 1995 Jun;309(6):322-5.
6. J Clin Endocrinol Metab. 1997 Feb;82(2):407-13.
7. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7.
8. Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7.
9. Comparison of effects of the rise in serum testosterone by raloxifene and oral testosterone on serum insulin-like growth factor-1 and insulin-like growth factor binding protein (http://www.allsportsnutrition.com/)-3.
Maturitas. 2005 Jul 16;51(3):286-93.
Written by symatech, Edited by hooker
(Testosterone)
[4-androsten-3-one-17beta-ol]
17beta-hydroxy-androst-4-en-3-one
Molecular Weight (of Base): 288.429
Molecular Weight (esters)
Propionate: 362.5082
Phenylpropionate: 438.6058
Isocaproate: 404.5886
Caproate:116.16
Formula (of Base): C19 H28 O2
Formula (esters)
Propionate:C3 H6 O2
Phenylpropionate:C9 H10 O2
Isocaproate:C6 H12 O2
Caproate:C16 H12 O2
Melting Point: 154-155C
Manufacturer: Jelfa
Effective dose: 250-1,000mgs/week
Active Life: 10 days
Detection Time: 3 months
Anabolic/Androgenic Ratio: 100:100
1 milliliter of Omnadren 250 contains:
30mg testosterone propionate
60mg testosterone phenylpropionate
60mg testosterone isocaproate
100mg testosterone caproate
Omnadren 250 is a combination of the 4 separate test esters listed above.
Older versions of the drug list the final two esters as ‘isohexanoate’
and ‘hexanoate.’ However, it should be noted that hexanoate is simply
another word for caproate so the drug’s esters have not actually been
modified. Most commonly, people will correlate Omnadren 250 with its
cousin Sustanon 250, since they are both a blend of 4 test esters. The
only difference between the two lies in the last –and most concentrated-
ester. Whilst Omnadren contains the caproate ester, Sustanon contains the
decanoate ester in the same concentration. Really, except for price, there’s no difference…and price-wise, you’re going to be paying ½ as much for Omnadren as you would for Sustanon (or $3-4usd/amp). This is a very nice price, and for that reason, I typically advise people to purchase Omnadren over Sustanon, if their source carries it.
It is also not uncommon to hear people refer to Omnadren as a superior version
of testosterone since it boasts 4 esters instead of 1 (or none). This
should be taken with a grain of salt. All testosterone’s produce very
similar effects while the ester simply delays the release of
the compound into the body which has two immediate consequences. The first
being less important; injection frequency. This has become a hotly debated
issue recently… on the one side are those who advocate injections only
once or twice per week. Frequently their arguments are supported with
cycle results which have yielded ‘good gains.’ On the other side –and
perhaps the more scientific side- are those who advocate injections at
least every other day (EOD) or ever day (ED). One has only to glance at
the ester constitution in Omnadren to understand why this may be . Such
small concentrations of the shorter esters (propionate and
phenylpropionate) are rendered practically useless when Omnadren is
injected once or twice per week. Furthermore, when injecting only a few
times per week the ‘peaks and valleys’ of concentration in the blood are
not desirable. We want our blood concentration of the drugs to be as high
as they can be –relative to dose- as long as they can be. Obviously, this
is not the case when fast acting esters are introduced and subsequently
dissipated before another injection is given.
As the longest ester in Omnadren (caproate) is slightly faster acting than the
longest ester in Sustanon (decanoate), users will notice an increase in
their testosterone levels sooner with Omnadren than with Sustanon. This
has a few consequences which we shall examine now. First of all, since
testosterone aromatizes (converts) to estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42), a buildup of this female
hormone will occur more rapidly. With estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42) increase follows the
inevitability of increased water retention. This is significant for 3
reasons: First, the user’s strength will increase. Secondly, the user’s
size will increase, and finally, definition in the muscles will begin to
dissipate. As an obvious result, Omnadren is typically used more for
bulking than cutting. The extent of these effects are highly dictated by
the user’s diet and training habits, although it is also easily controlled
with the proper use of anti-estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42) drugs such as Nolvadex (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=43), Armidex, Proviron, and a myriad of others.
As I previously stated, testosterone is a highly anabolic and androgenic hormone, it has an anabolic (muscle building) rating of 100, making it a good drug to use if one is in pursuit of more size and strength. And if you aren’t in pursuit of more size and strength, then why would you be reading this, right? Well, let’s get on with it and look at exactly what makes testosterone a good mass builder. Firstly, testosterone promotes nitrogen retention in the muscle(6) the more nitrogen the muscles holds the more protein (http://www.allsportsnutrition.com/) the muscle stores. Testosterone can also increase the levels of the highly anabolic hormone, IGF-1, in muscle tissue(7)(9). Even the aromatized part of testosterone that turns into estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42) may increase levels of IGF, and sensitivity to it. Testosterone’s actions come mostly from it’s binding to the androgen receptor to promote A.R dependant mechanisms for both muscle gain and fat (http://www.allsportsnutrition.com/) loss (5). Thankfully, it also significantly increases the concentrations of the A. R in cells critical for muscle repair and growth and A.R in muscle(8 ). Testosterone induces changes in shape, size and also can change the appearance and the number of muscle fibers(7). Androgens like the testosterone(s) found in Omnadren can protect your hard earned muscle from the catabolic hormones(8), whether those hormones occur from exercise or other stress.
There are strong androgenic side effects, which are pronounced with
Omnadren (as with all testosterones). Oily skin, acne, increased body/facial hair, and depending on the individual an increase in aggressiveness can
occur. Omnadren can also be hard on the hairline. This is partly due to
the conversion of the testosterone into dihydrotestosterone (DHT). Test is
converted to DHT via the 5-alpha reductase enzyme. While DHT is more
potent than test at the androgen receptor (the double bond is removed from
the carbon4-carbon5 bond and replaced with a hydrogen atom on each)
and is responsible for some growth. It can also cause some negative side
effects as well. Testosterone, because of this bond is actually much more anabolic, in practical terms, because it For example: DHT formation in the scalp is suspected of
causing/expediting male pattern baldness. To possibly combat this, one can
use finasteride (Proscar (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=44)®). This drug will inhibit the conversion of
testosterone to DHT but many users will report that since DHT is more
potent at the androgen receptor than test, gains in muscle mass as well as
strength will diminish. On the other hand, a lack of DHT caused by blocking 5-AR can sometimes cause gynocomastia (4)(5).
Typically cycles which contain Omnadren 250 will be around 12-16
weeks. The idea is that it will take at least 2 weeks for the compound to
become fully ‘active’ in the body, and most users will report an
additional 1-3 weeks until the effects of Omnadren are truly felt. As a
result, gains from Omnadren are not typically noticed for about 1 month
after the first injection. What most people mean by this is that although the actual drug is already active, gains aren’t realized immediately. The majority of users willsupplement a fast acting oral drug such as Dianabol or Anadrol in the first 4 weeks of a
cycle which is thought of as a ‘kickstart’ until the effects of the
Omnadren are fully felt. As mentioned above a typical weekly dose of
Omnadren can range from 500mg-1000mg per week. Those who are new to
steroids and cycling should generally start with a minimal dose so as to better
judge how their own bodies will react to the synthetic testosterone. I’d suggest beginners sitck with 2 amps per week, if they’re inclined to use this preparation.
Omnadren has always been manufactured by Polfa© which has since changed
their name to Jelfa©. The company is based in Poland, and as one might
obviously conclude, the availability and price of Omnadren 250 there is
much different than many other places. Often, fake Sustanon in the 80’s would actually turn out to be Omnadren, which was much less highly prized (nonsensically).
References:
1. Hypothalamic sites of action for testosterone, dihydrotestosterone, and estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42) in the regulation of luteinizing hormone secretion in male sheep. Endocrinology. 1997 Sep;138(9):3686-94.
2. Inhibition of LH Secretion by Localized Administration of Estrogen (http://www.anabolicreview-research.com/shop/product_info.php?cPath=23&products_id=42), but not Dihydrotestosterone, Is Enhanced in the Ventromedial Hypothalamus During Feed Restriction in the Young Wether.
Biol Reprod. 2005 Jun 22; [Epub ahead of print]
3. Crystalline dihydrotestosterone implants in the lateral septum of male rats. A positive effect on LH and FSH.
Endocr Res. 2001 Feb-May;27(1-2):35-40.
4. Significant role of 5 alpha-reductase on feedback effects of androgen in rat anterior pituitary cells demonstrated with a nonsteroidal 5 alpha-reductase inhibitor ONO-3805. J Androl. 1994 Nov-Dec;15(6):521-7.
5. Case report: finasteride-induced gynecomastia in a 62-year-old man.
Am J Med Sci. 1995 Jun;309(6):322-5.
6. J Clin Endocrinol Metab. 1997 Feb;82(2):407-13.
7. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7.
8. Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7.
9. Comparison of effects of the rise in serum testosterone by raloxifene and oral testosterone on serum insulin-like growth factor-1 and insulin-like growth factor binding protein (http://www.allsportsnutrition.com/)-3.
Maturitas. 2005 Jul 16;51(3):286-93.
Written by symatech, Edited by hooker