all natural muscle builders!?!?

[Rip it]

well i'v been looking around alittle and i learned some neat things and some all natural herbs. take garlic for example did you know that it helps with the NOS production. i didn't. also i L-Arginine is a big part of the NOS production. My question is what herbs, amino acids and other natural stuff helps with build muscle.

[Rip it]

NOS is a heme-containing enzyme with some sequences similar to cytochrome P-450 reductase. Several isoforms of NOS exist, two of which are constitutive and one of which is inducible by immunological stimuli. The constitutive NOS found in the vascular endothelium is designated eNOS and that present in the brain, spinal cord and peripheral nervous system is designated nNOS. The form of NOS induced by immunological or inflammatory stimuli is known as iNOS. iNOS may be expressed constitutively in select tissues such as lung epithelium. All the nitric oxide synthases use NADPH (reduced nicotinamide adenine dinucleotide phosphate) and oxygen (O2) as cosubstrates, as well as the cofactors FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide), tetrahydrobiopterin and heme. Interestingly, ascorbic acid appears to enhance NOS activity by increasing intracellular tetrahydrobiopterin. eNOS and nNOS synthesize NO in response to an increased concentration of calcium ions or in some cases in response to calcium-independent stimuli, such as shear stress.
In vitro studies of NOS indicate that the Km of the enzyme for L-arginine is in the micromolar range. The concentration of L-arginine in endothelial cells, as well as in other cells, and in plasma is in the millimolar range. What this means is that, under physiological conditions, NOS is saturated with its L-arginine substrate. In other words, L-arginine would not be expected to be rate-limiting for the enzyme, and it would not appear that supraphysiological levels of L-arginine^which could occur with oral supplementation of the amino acid^would make any difference with regard to NO production. The reaction would appear to have reached its maximum level. However, in vivo studies have demonstrated that, under certain conditions, e.g. hypercholesterolemia, supplemental L-arginine could enhance endothelial-dependent vasodilation and NO production.
The discordance between the in vivo results^increased NO production under certain conditions^and the in vitro enzyme studies described above is known as the "arginine paradox." There are a few explanations for the "arginine paradox." NOS may be inhibited by asymmetric dimethylarginine or ADMA, which is known to be elevated in hypercholesterolemia and which increases mononuclear cell (monocyte and T-lymphocyte) adhesiveness in hypercholesterolemics. ADMA is formed by post-translational methylation of L-arginine residues in proteins and is released from the proteins following their hydrolysis. The "arginine paradox" may be explained in part by increasing levels of L-arginine overcoming the inhibition of NOS by ADMA. In addition to hypercholesterolemia, elevated levels of ADMA are associated with hypertension, diabetes, preeclampsia, smoking and aging. Elevation of ADMA may be due to altered metabolism of this substance by dimethylarginine dimethylaminohydrolase or DDAH. DDAH is the major enzyme involved in ADMA catabolism. Decreased levels of DDAH have been found in diabetic and hypercholesterolemic animal models.

[Rip it]

GARLIC AND NOS

results suggest that garlic can increase NOS activity both in cells and in cell-free systems. The activity of caNOS increases several-fold upon addition of garlic extract to freshly prepared cell-free homogenates of placental villi. Although arginine (the precursor of NO) is present in garlic, the activation of caNOS is independent of this substrate. The activation is partially abolished when garlic is heated but is unaffected by perchloric acid treatment. Both NOS and GTPCH-1 activities are increased by incubation of choriocarcinoma cells with garlic, and this effect is probably due to activation of the inducible isoforms. Low concentrations of garlic can also increase polyamines (which are also produced from arginine via the enzyme ornithine decarboxylase)(5) within these cells and these substances promote growth and cellular differentiation. When pieces of placental tissue were incubated with extracts of garlic, this also caused increased NOS activity.

[taiotosh7]

Stimulants and high doses of glutamine hinder vasodilation

[IBdmfkr]

BCAA's are essential IMO. As well as a well-rounded dietary approach for a user or a drug-free athelete.

[copenhagen]

proper diet=best natural muscle builder