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  1. #1
    mmaximus25 is offline Senior Member
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    Long R3 IGF-1....better than GH? very interesting

    Long R3 IGF-1

    My friend is working with this right now in a supposed research capacity I assume... A buddy that just used in a cycle sent me this article. My friends all have proclaimed this as the drug to surpass GH... I have two friends that have used this and for starters it is not something everyone will have access to an will not be greatly attainable in any near future... (FDA sucks cock…. F%ck Little b!tches) sorry for that…
    The only fear is the unknown.... I believe IGF-1 long R3 with heavy doses of AAS, insulin and growth is the danger... but alone or with moderate doses of AAS would be the safer health conscience method.

    I must say one of the two friends is not exactly health conscience and already has an enlarged heart but the other a more moderate user of designer BBing drugs is much more health conscience... I am currently trying to milk information as to their health and well being while using IGF-1 Long R3

    IGF-1 Long R3

    1. IGF stands for insulin-like growth factor. It is a

    natural substance that is produced in the human body

    and is at its highest natural levels during puberty.

    During puberty IGF is the most responsible for the

    natural muscle growth that occurs during these few

    years. There are many different things that IGF does

    in the human body; I will only mention the points that

    would be important for physical enhancement. Among the

    effects the most positive are increased amino acid

    transport to cells, increased glucose transport,

    increased protein synthesis, decreased protein

    degradation, and increased RNA synthesis.



    When IGF is active it behaves differently in different

    types of tissues. In muscle cells proteins and

    associated cell components are stimulated. Protein

    synthesis is increased along with amino acid

    absorption. As a source of energy, IGF mobilizes fat

    for use as energy in adipose tissue. In lean tissue,



    IGF prevents insulin from transporting glucose across

    cell membranes. As a result the cells have to switch

    to burning off fat as a source of energy.



    IGF also mimic's insulin in the human body. It makes

    muscles more sensitive to insulin's effects, so if you

    are a person that currently uses insulin you can lower

    your dosage by a decent margin to achieve the same

    effects, and as mentioned IGF will keep the insulin

    from making you fat.



    Perhaps the most interesting and potent effect IGF has

    on the human body is its ability to cause hyperplasia,

    which is an actual splitting of cells. Hypertrophy is

    what occurs during weight training and steroid use , it

    is simply an increase in the size of muscle cells.

    See, after puberty you have a set number of muscle

    cells, and all you are able to do is increase the size

    of these muscle cells, you don't actually gain more.

    But, with IGF use you are able to cause this

    hyperplasia which actually increases the number of

    muscle cells present in the tissue, and through weight

    training and steroid usage you are able to mature

    these new cells, in other words make them grow and

    become stronger. So in a way IGF can actually change

    your genetic capabilities in terms of muscle tissue

    and cell count. IGF proliferates and differentiates

    the number of types of cells present. At a genetic

    level it has the potential to alter an individuals

    capacity to build superior muscle density and size.



    There is a lot of talk about the similarity between

    IGF and growth hormone . The most often asked question

    is simply which is more effective. GH doesn't directly

    cause your muscles to grow, it works very indirectly

    by increasing protein synthesis capabilities,

    increasing the amount of insulin a person can use

    effectively, and increasing the amount of anabolic

    steroids a person can use effectively. GH also

    indirectly causes muscle growth by stimulating the

    release of IGF when it (the GH) is destroyed in the

    human body. So one way you could look at it as GH

    being a precursor to IGF. So to put it simple IGF is

    more effective at directly causing muscle growth and

    density increases. IGF is also much more cost

    effective.



    IGF can also be effectively used by itself and gains

    will still be easily noticeable. With growth hormone

    you need to use high amounts of anabolics and often

    insulin to see any gains at all, this is not the case

    with IGF. IGF can be used by itself and is often used

    by bodybuilders who bridge between cycles, during this

    bridge is a good time to use IGF since it has no

    effect on natural testosterone production so it will

    therefore allow you to return to normal in terms of

    hormone levels. A stack of IGF, PGF2a, HCG , and clomid

    would be a good bridge stack and would allow your body

    to return to normal and still allow you to retain and

    make new gains.

    IGF is a research drug, it hasn't been approved by the

    FDA for use as a pharmaceutical and it is currently

    being researched for nerve tissue repair, possible

    burn victims, and also as a possible aid in muscle

    wasting for AIDS patients. There are many different

    analogs of IGF available, instead of mentioning them

    all, I will simply mention the two most common and the

    most effective. Regular recombinant IGF is one of the

    two, it is also the more expensive and the least

    effective. Regular IGF only has a half-life of about

    10-20 minutes in the human body and is quickly

    destroyed, it can be combined with certain binding

    proteins to extend the half-life, but it is not a very

    simple procedure and there is a more effective and

    less expensive version available. The most effective

    form of IGF is Long R3 IGF-1, it has been chemically

    altered and has had amino acid changes which cause it

    to avoid binding to proteins in the human body and

    allow it to have a much longer half life, around 20-30

    hours. "Long R3 IGF-1 is an 83 amino acid analog of

    IGF-1 comprising the complete human IGF-1 sequence

    with the substition of an Arg(R) for the Glu(E) at

    position three, hence R3, and a 13 amino acid

    extension peptide at the N terminus. This analog of

    IGF-1 has been produced with the purpose of increasing

    the biological activity of the IGF peptide."



    "Long R3 IGF-1 is signifacantly more potent than

    IGF-1. The enhanced potency is due to the decreased

    binding of Long R3 IGF-1 to all known IGF binding

    proteins. These binding proteins normally inhibit the biological actions of IGF's."



    It is also not as expensive since a media grade

    version is available which is sufficient for

    bodybuilding use. There is also a receptor grade

    available but it is VERY expensive and the only

    noticeable difference between the two would only be

    able to be noticed in a laboratory setting. The price

    on the black market for Long R3 IGF-1 can be seen

    anywhere from $300-$500 per milligram depending on the

    source, be wary of black market dealers of any IGF

    since it is a VERY difficult item to obtain. As

    mentioned IGF is a research product and is only

    available from a few laboratories in the world and is

    only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.



    Any form of IGF is ONLY supplied in a lyphosized form,

    which means a dry powder state. NEVER PUCHASE

    PRE-DILUTED LIQUID IGF!!!! There is no such product

    made anywhere in the world and even if there were real

    IGF ever present in the vial it would all be dead by

    the time you receive it. IGF is a very delicate

    peptide and must be diluted by yourself, where you

    have access to a refrigerator and freezer. There has

    also been a lot of talk by certain sources claiming to

    have IGF made by the Eli Lilly company, to clear

    things up Lilly is a pharmaceutical company and as

    stated IGF is a research drug and has not yet been

    approved, Lilly does not and never has manufactured

    research drugs for retail sale.



    The dilutents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer(sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the dilutents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary dilutents.



    The most effective length for a cycle of IGF is 50

    days on and 20-40 days off. The most controversy

    surrounding Long R3 IGF-1 is the effective dosage. The

    most used dosages range between 20mcg/day to

    120+mcg/day. IGF is only available by the milligram,

    one mg will give you a 50 day cycle at 20mcg/day, 2mg

    will give you a 50 day cycle at 40mcg/day, 3mg will

    give you a 50 day cycle at 60mcg/day, 4mg will give

    you a 50 day cycle at 80mcg/day and so on. The dosage

    issue mainly revolves around how much money you have

    to spend, plenty of people use the minimum dosage of

    20mcg/day and are happy with the results, and in fact

    several top bodybuilders use the 20mcg/day dosage and

    are pleased with the results. IGF is most effective

    when administered subcutaneously and injected once or

    twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training.



    Another frequently asked question of IGF refers to the

    real world results, in terms of pure weight gain don't

    expect to gain 5 lbs. a week like you may off of

    anadrol or a similar steroid. The only weight you will

    gain from IGF use is pure lean muscle tissue, with

    steroids most of the weight gained is water weight.

    With an effective dosage you can expect to gain 1-2

    lbs of new lean muscle tissue every 2-3 weeks and

    these effects can be increased with the use of

    testosterone, anabolic steroids , and insulin use.

    Increased vascularity is also very common, people

    report seeing veins appear where they never have

    before. And yet another effect reported is the ability

    to stay lean while bulking with heavy dosages of

    steroids and TONS of food while on an IGF cycle, this

    is perhaps the most pleasing effect. Increased pumps

    are also noticeable almost immediately, the pumps can

    almost become painful, pumps are even noticeable when

    doing cardio.



    Overall, IGF is a very exciting drug due to its

    ability to alter ones genetic capabilities. If you can

    find a trustworthy source and you use it correctly it

    can be a VERY useful tool in your bodybuilding drug arsenal.

  2. #2
    asymmetrical1's Avatar
    asymmetrical1 is offline Respected Member
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    good read.....bayou mike you read this?

  3. #3
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    on the MC board there is a whole forum dedicated to IGF-1, with most of it referring to IGF-1 LR3. I can't post a link to that forum, but if you don't know what MC is, you can pm me. It's hard to compare GH and IGF-1, since most of the welcomed effects of GH are from GH stimulating increased IGF-1 production. Dollar for dollar, IGF-1 LR3 is the way to go. As far as prices, those above are way high. If you pay more than $200/mg, you're getting screwed. There are a few companies that I know of that sell 3mg for $550.

  4. #4
    dizzle's Avatar
    dizzle is offline Respected Member
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    I finished my first cycle of IGF a few weeks ago. Definetly can feel a change when I was on it and off.

  5. #5
    Da Bull's Avatar
    Da Bull is offline Banned
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    Same here..loved it

  6. #6
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    Now since I've never done IGF and Insuline there's one thing I don't understand...

    Your article says the most effective duration of a cycle is 50 days on and
    20-40 days off
    (while most people on this board advocate a 20-30 day cycle, but that may well be cost-related --> I personally with any cycle always do MINIMUM of Time "on" is Time "off" so 50 days on would mean a minimum of 50 days off!)

    But since IGF-L3 is most effective when used in conjunction with Insuline (so to longer its effects due to otherwise BP3 binding to it and other "nasty processes") wouldn't 50 days of consecutive use of Insuline be a bit risky for a healthy person (so a non-diabetic)?

    Also I want to know; I always train 4-5 days a week, so if I use IGF-L3 and Insuline I should also take it on my "non training days" but when would be the best time of day for that then?

    And what would be more effective?
    Shooting twice a day (and at what subjective times --> e.g. first thing in the morning, post-workout, before bed, with meals... You get the point!)
    or
    Shooting once (probably post-workout)...

    Thanks for the input on these questions
    Kingofmasters

  7. #7
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    Quote Originally Posted by kingofmasters
    Now since I've never done IGF and Insuline there's one thing I don't understand...

    Your article says the most effective duration of a cycle is 50 days on and
    20-40 days off
    (while most people on this board advocate a 20-30 day cycle, but that may well be cost-related --> I personally with any cycle always do MINIMUM of Time "on" is Time "off" so 50 days on would mean a minimum of 50 days off!)

    But since IGF-L3 is most effective when used in conjunction with Insuline (so to longer its effects due to otherwise BP3 binding to it and other "nasty processes") wouldn't 50 days of consecutive use of Insuline be a bit risky for a healthy person (so a non-diabetic)?

    Also I want to know; I always train 4-5 days a week, so if I use IGF-L3 and Insuline I should also take it on my "non training days" but when would be the best time of day for that then?

    And what would be more effective?
    Shooting twice a day (and at what subjective times --> e.g. first thing in the morning, post-workout, before bed, with meals... You get the point!)
    or
    Shooting once (probably post-workout)...

    Thanks for the input on these questions
    Kingofmasters
    IGF-1 LR3 is IGF-1 with a point mutation to increase binding affinity and also an additional stretch of amino acids, which do not affect its binding to IGF receptors but which renders it unsusceptible to being bound by IGFBPs, so the insulin to increase IGFBPs and therefore half-life is really only for regular IGF-1, which is obsolete in the days of LR3 availability. However, since insulin and IGF-1 share much homology, as do their receptors, the use of the two together has the effect of upregulation of their own and each other's receptors (initially) when introduced at supraphysiological levels, which then increases the potency of each, per se. For that reason, if no other, a 30 day cycle is best suited for using the two together.
    Resistance training causes upregulation of IGF receptors in the muscles worked, so shooting post workout into the muscles just worked creates, statistically/kinetically, the best opportunity for effects in that/those muscles. it's not clear for how long IGF receptors are upregulated, so shootin gin the AM on an off day into the muscles worked the previous workout is what I do. Alternatively, you could JUST shoot the combo ob workout days. LR3 is also going to cause feedback inhibition and suppress endogenous GH release, so 2x/day administration provides nearly a 24 hour suppressive effect on GH release.

    The article above is also a bit dated.

  8. #8
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    Quote Originally Posted by einstein1905
    IGF-1 LR3 is IGF-1 with a point mutation to increase binding affinity and also an additional stretch of amino acids, which do not affect its binding to IGF receptors but which renders it unsusceptible to being bound by IGFBPs, so the insulin to increase IGFBPs and therefore half-life is really only for regular IGF-1, which is obsolete in the days of LR3 availability. However, since insulin and IGF-1 share much homology, as do their receptors, the use of the two together has the effect of upregulation of their own and each other's receptors (initially) when introduced at supraphysiological levels, which then increases the potency of each, per se. For that reason, if no other, a 30 day cycle is best suited for using the two together.
    Resistance training causes upregulation of IGF receptors in the muscles worked, so shooting post workout into the muscles just worked creates, statistically/kinetically, the best opportunity for effects in that/those muscles. it's not clear for how long IGF receptors are upregulated, so shootin gin the AM on an off day into the muscles worked the previous workout is what I do. Alternatively, you could JUST shoot the combo ob workout days. LR3 is also going to cause feedback inhibition and suppress endogenous GH release, so 2x/day administration provides nearly a 24 hour suppressive effect on GH release.

    The article above is also a bit dated.
    Thanks Einstein --> You da Man!

    But just to summarize (what you say) best is:

    1) Once a day Post Work-out (better then injecting twice a day)
    2) On "off" days shooting First thing in the Morning
    3) Optional: Only shooting on Work-out days

    Did I understand it right?

    If so, what is your theory on Option 3
    --> Wouldn't a consecutive adminstration of IGF
    every day during entire IGF-cycle
    be much more effective than this "on"/"off" aproach?
    (so shooting on work-out days and not shooting on weekends for instance)

    Greets
    Kingofmasters
    Last edited by kingofmasters; 05-29-2004 at 03:41 PM.

  9. #9
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    Shooting ED is what I do. the only good reason to just inject on workout days would be financial reasons IMO.



    Quote Originally Posted by kingofmasters
    Thanks Einstein --> You da Man!

    But just to summarize (what you say) best is:

    1) Once a day Post Work-out (better then injecting twice a day)
    2) On "off" days shooting First thing in the Morning
    3) Optional: Only shooting on Work-out days

    Did I understand it right?

    If so, what is your theory on Option 3
    --> Wouldn't a consecutive adminstration of IGF
    every day during entire IGF-cycle
    be much more effective than this "on"/"off" aproach?
    (so shooting on work-out days and not shooting on weekends for instance)

    Greets
    Kingofmasters

  10. #10
    mistasmif is offline Junior Member
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    How do you do a 20mcg injection? Isn't that microscopic?

  11. #11
    Mr. Sparkle's Avatar
    Mr. Sparkle is offline Slinabolic Vet / Retired
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    use a slin pin bro

  12. #12
    Rampage Jackson's Avatar
    Rampage Jackson is offline Junior Member
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    ****...I'm really interested in this stuff now!

  13. #13
    georgie24's Avatar
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    yea bump

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