Anabolics
Search More Than 6,000,000 Posts
Results 1 to 15 of 15
  1. #1
    Psycoswole's Avatar
    Psycoswole is offline Member
    Join Date
    Oct 2001
    Location
    Vegas, NV
    Posts
    957

    GHRP (growth hormone release peptide-2)

    These are supposedly sublingual growth hormone tabs. Anyone ever tried them, heard more about them or know how to take them (5on 2off?). Im getting my hands on some and will be runnin it with my cycle, any feed back helps.
    Last edited by Psycoswole; 11-04-2001 at 01:03 PM.

  2. #2
    gearedup is offline RETIRED VET R.I.P.
    Join Date
    Sep 2001
    Posts
    651
    I have heard from a bunch of people that they aren't any better than taking a pez! I don't know if its true... it might be like the people that do 2iu's of GH for 4 weeks then go around saying its worthless!

  3. #3
    Roid Rogers is offline Junior Member
    Join Date
    Sep 2001
    Location
    tx
    Posts
    81
    ghrp is shit , if your looking for something that will boost your gh naturally there is some stuff called MGF-1 forgot who its buy but i took it and it worked pretty well but i did have moon face from the mixing of carnitine and therine but i got cut up

  4. #4
    silverfox's Avatar
    silverfox is offline Retired Moderator
    Join Date
    Nov 2001
    Posts
    1,911

    GHRP2

    They are not bad, the key is to let them desolve under your tounge for at least 15min. I space them out about every 3-4 hours during the day/night. I have pasted some sticking points, BUT, also using slin/test/deca /winny

  5. #5
    CYCLEON Guest
    gh bosters are a scam - growth hormone releasing peptides are not however. I dont know how well they work in the field and im sure a few vets will come spit on my post but the real scientific studies do show that the substance does work. Thats also why you dont see Muscletek selling any either.


    The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs
    D Wu, C Chen, J Zhang, C Y Bowers(1) and I J Clarke
    Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia and (1) Department of Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112, USA
    (Requests for offprints should be addressed to C Chen)

    Abstract
    The mechanism of action of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on GH release was investigated in ovine and rat pituitary cells in vitro. In partially purified sheep somatotrophs, GHRP-2 and GH-releasing factor (GRF) increased intracellular cyclic AMP (cAMP) concentrations and caused GH release in a dose- dependent manner; GHRP-6 did not increase cAMP levels. An additive effect of maximal doses of GRF and GHRP-2 was observed in both cAMP and GH levels whereas combined GHRP-6 and GHRP-2 at maximal doses produced an additive effect on GH release only. Pretreatment of the cells with MDL 12,330A, an adenylyl cyclase inhibitor, prevented cAMP accumulation and the subsequent release of GH that was caused by either GHRP-2 or GRF. The cAMP antagonist, Rp-cAMP also blocked GH release in response to GHRP-2 and GRF. The cAMP antagonist did not prevent the effect of GHRP-6 on GH secretion whereas MDL 12,330A partially reduced the effect. An antagonist for the GRF receptor, [Ac- Tyr(1) ,d- rg(2) ]-GRF 1-29, significantly diminished the effect of GHRP-2 and GRF on cAMP accumulation and GH release, but did not affect GH release induced by GHRP-6. Somatostatin prevented cAMP accumulation and GH release responses to GHRP-2, GRF and GHRP-6. Ca(2+) channel blockade did not affect the cAMP increase in response to GHRP-2 or GRF but totally prevented GH release in response to GHRP-2, GRF and GHRP-6. These results indicated that GHRP-2 acts on ovine pituitary somatotrophs to increase cAMP concentration in a manner similar to that of GRF; this occurs even during the blockade of Ca(2+) influx. GHRP-6 caused GH release without an increase in intracellular cAMP levels. GHrelease in response to all three secretagogues was reduced by somatostatin and was dependent upon the influx of extracellular Ca(2+) . The additive effect of GHRP-2 and GRF or GHRP-6 suggested that the three peptides may act on different receptors. In rat pituitary cell cultures, GHRP-6 had no effect on cAMP levels, but potentiated the effect of GRF on cAMP accumulation. The synergistic effect of GRF and GHRP-6 on cAMP accumulation did not occur in sheep somatotrophs. Whereas GHRP-2 caused cAMP accumulation in sheep somatotrophs, it did not do so in rat pituitary cells. These data indicate species differences in the response of pituitary somatotrophs to the GHRPs and this is probably due to different subtypes of GHRP receptor in rat or sheep.
    --------------------------------------------------------------------------------
    New test offers advantages over insulin tolerance test for diagnosis of growth hormone deficiency
    Print Email

    NEW YORK, Oct 2 (Praxis Press) The insulin tolerance test (ITT) used to diagnose growth hormone (GH) deficiency in adults has several drawbacks, including limited reproducibility, absence of a normal range, and contraindication in certain clinical situations. Popovic and colleagues studied the safety, convenience, and reliability of a new provocative test in 125 adult patients with known organic pituitary disease and severe GH deficiency (GH peak after ITT of !U?3 micrograms/L) and 125 healthy adult controls. The test entailed intravenous administration of GH-releasing hormone (GHRH, 1 micrograms/kg) plus GH-releasing peptide-6 (GHRP-6, 1 micrograms/kg) followed by tracking of GH levels for 120 minutes. The GH peaks triggered by the GHRH/GHRP-6 test did not produce any side effects, differ between men and women, correlate with age or body mass index, or vary with the use of different GH assays. Mean GH peaks after the GHRH/GHRP-6 test were 59.2 !A` 2.2 micrograms/L in controls and 4.1 !A` 0.3 micrograms/L in patients; corresponding mean GH peaks after the ITT were 14.3 !A` 1.7 micrograms/L and 0.5 !A` 0.06 micrograms/L. The difference between patient and control GH peaks was greater when using the GHRH/GHRP-6 test than when using the ITT (P < 0.001). Although GH peaks using the GHRH/GHRP-6 test spanned a continuum for both patients and controls, a cut-off value of 15 micrograms/L largely differentiated between the two groups. For the GHRH/GHRP-6 test, the authors propose that GH peak values of 20.00 micrograms/L and greater be considered normal and values of 10.00 micrograms/L and less be considered an indication of GH deficiency. The accompanying commentary notes that the GHRH/GHRP-6 test may be better for patients with pituitary disease, whereas the ITT may be better for patients with hypothalamic disease; it also argues for continued efforts toward global standardization of GH immunoassays.
    ________________________________________

    Authors
    Frieboes RM, Murck H, Antonijevic IA, Steiger A.
    Title
    Effects of growth hormone-releasing peptide-6 on the nocturnal secretion of GH, ACTH and cortisol and on the sleep EEG in man: Role of routes of administration
    Source
    Journal of Neuroendocrinology. 11(6):473-478, 1999 Jun.
    Author Keywords
    Growth hormone, Growth hormone-releasing peptides, Corticotropins, Clinical neuroendocrinology, Sleep.
    KeyWords Plus® by ISI®
    Normal men, Factor-i, Secretagogue, Receptor, Hexarelin, Pituitary, Insulin, Intranasal, Prolactin, Efficacy.

    Abstract
    After repeated intravenous (i.v.) boluses of growth hormone-releasing peptide-6 (GHRP-6) we found recently increases of growth hormone (GH), corticotropin (ACTH) and cortisol levels and of the amount of stage 2 sleep, In clinical use, oral (p.o.), intranasal (i.n.) and sublingual (s.l.) routes of administration have advantages over i.v. administration, We compared the sleep-endocrine effects of 300 mu g/kg of body weight (b.w.) GHRP-6 in enteric-coated capsules given p.o. at 21.00 h and of 30 mu g/kg GHRP-6 i.n. or 30 mu g/kg GHRP-6 st. given at 22.45 h in normal young male controls with placebo conditions. After GHRP-6 p.o. secretion of GH, ACTH and cortisol remained unchanged. The only effect of GHRP-6 s.l. was a trend toward an increase in GH in the first half of the night. GHRP-6 i.n. prompted a significant increase in GH concentration during the total night and a trend toward an increase in ACTH secretion during the first half of the night, whereas cortisol secretion remained unchanged. Furthermore, after GHRP-6 i.n., sleep stage 2 increased in the second half of the night by trend, and spectral analysis of total night non-rapid eye movement (REM) sleep revealed a decrease of delta power by trend. In contrast sleep stage 2 decreased during the second half of the night after GHRP-6 p.o. Our data demonstrate that GHRP-6 is capable of modulating GH and ACTH secretion as well as sleep. However, the effects depend upon dosage, duration and route of administration. [References: 41]
    -------------------------------------------------------------------------------

    The secretion of growth hormone (GH) from the pituitary gland is regulated by the central nervous system. At the hypothalamic level, two peptides, growth hormone releasing hormone (GHRH) and somatostatin modulate the secretion of GH. GHRH stimulates GH secretion while somatostatin exhibits an inhibitory influence.

    Other peptides of different size and structure are able to influence GH secretion in man and several other animal species. Amongst these, a synthetic hexapeptide (GHRP-6), derived from an enkephalin analogue, specifically stimulates GH release both after parenteral and oral administration. The oral activity of GHRP-6 has opened up new perspectives in the treatment of several conditions associated to hypothalamic growth hormone deficiency. It has also prompted the development of new synthetic peptides, possessing greater potency, a longer duration of action and an increased oral bioavailability.

    Hexarelin (INN:Examorelin, MF 6003, EP 23905) is a new synthetic peptide formed by 6 aminoacids. Its chemical structure is His-DTrp(2-Me)-Ala-Trp-DPhe-Lys-NH2. Compared to GHRP-6, hexarelin is more resistant to proteolytic degradation.

    An extensive package of toxicological studies has been performed. No organ specific toxicity was observed. No toxic effects were recorded on the cardiovascular system, renal function and CNS. Pharmacokinetic studies are available in rats and dogs. The drug is absorbed by the subcutaneous and oral routes. The half-life of hexarelin is 2 hours in dogs after bolus iv administration.

    Hexarelin stimulates GH secretion following intravenous, subcutaneous, intranasal and oral administration. In man, a bolus intravenous dose of 1 mg/kg induces peak plasma GH concentrations of around 70 ng/mL within 15 minutes. The mechanism of action of hexarelin has still not been fully elucidated. The peptide seems to act on pituitary binding-sites and to modulate intracellular messenger pathways different from those associated with GHRH. Its low toxicity, marked and specific stimulation of GH secretion along with its rapid absorption after oral administration, strongly indicate that it could be employed as a diagnostic and therapeutic tool in GH secretory disorders.

    High-affinity binding sites for hexarelin have been identified in human cardiac and vascular tissues. Various animal models have evidenced a strong protective effect of hexarelin in post-ischemic ventricular dysfunction. Hexarelin improves cardiac function in rats with experimentally induced congestive heart failure. These cardiovascular effects have also been observed in hypophysectomized animals and occur at doses far lower than those required to elicit GH secretion.

    Hexarelin has been administered to about 1,000 subjects. Phase 1 studies have shown that the drug is well tolerated after i.v. administration of doses up to 2 mg/kg. Chronic intranasal administration of hexarelin has been shown to accelerate growth in short children. Endocrine effects have been demonstrated after chronic oral administration in elderly subjects.

  6. #6
    Psycoswole's Avatar
    Psycoswole is offline Member
    Join Date
    Oct 2001
    Location
    Vegas, NV
    Posts
    957
    Vewy vewy intewesting. Where did you find those studies at? Good post CYC

  7. #7
    CYCLEON Guest
    I was looking into it a few months ago myself - did the research and so far it looks good - of course its not going to be like injecting 4iu a day but its much cheaper. thought the eye_candy post about letting them dissolve might be key.

  8. #8
    CYCLEON Guest
    well - much like GH, it is not scheduled - it may be a prescription only product but I doubt this, as it is still experimental, I believe. If this is the case then obtaining it would be perfectly legal.

  9. #9
    Psycoswole's Avatar
    Psycoswole is offline Member
    Join Date
    Oct 2001
    Location
    Vegas, NV
    Posts
    957
    Originally posted by CYCLEON
    of course its not going to be like injecting 4iu a day but its much cheaper.
    Thats an understatement, ill be paying twice as much just for my armidex. Thanks for the help CYC

  10. #10
    marky is offline New Member
    Join Date
    Nov 2001
    Location
    JOCO, Ks
    Posts
    10

    GEREF

    Heres a real GH releaser. Far cheaper than recombinant GH, its
    an injectable pituitary stimulator of HGH.

    http://www.howkidsgrow.com/serono_G/reimburs.html

  11. #11
    samoth's Avatar
    samoth is offline Member
    Join Date
    Sep 2001
    Location
    Kadath
    Posts
    678

    Check out Vox's newsletter


  12. #12
    JY28Newguy is offline New Member
    Join Date
    Mar 2002
    Location
    aventura
    Posts
    3
    What do you guys think about using Nutropin or Serastin?

    Is it worth the money?

  13. #13
    bigedd3105's Avatar
    bigedd3105 is offline New Member
    Join Date
    Jan 2002
    Location
    London
    Posts
    19
    bump

  14. #14
    dtdionne's Avatar
    dtdionne is offline Junior Member
    Join Date
    Jun 2002
    Posts
    112
    Anyone tried humagro?

  15. #15
    Syr's Avatar
    Syr
    Syr is offline New Member
    Join Date
    Mar 2005
    Posts
    45
    Quote Originally Posted by Roid Rogers
    ghrp is shit , if your looking for something that will boost your gh naturally there is some stuff called MGF-1 forgot who its buy but i took it and it worked pretty well but i did have moon face from the mixing of carnitine and therine but i got cut up
    Where do u can get it? Mechano Grow Factor is like IGF-1 but affect muscle tissue only and its damn powerful.

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •