My Detailed Nebido Log

[markwilliams]

Hello!

First of all, Happy New Year to everyone.

I'd like to thank you for your support, and give back to the community by attaching my detailed Nebido log, from March 2018.

I'm 30 y/o, 6', 220 lbs, 40% body fat.



SYMPTOMS

I felt pretty much like garbage the whole time, especially during the first three injections. Mood swings, sexual desire coming back only for a week, I gained weight (fourteen pounds, mostly abdominal fat), always tired, anxiety in the first weeks of injection n°4 and 5 (I never experienced anxiety in my life).

PROTOCOL

Three different endos made me skip the booster shot. Injection went from every twelve weeks to eight.

If you have any questions, feel free to ask. I'm currently trying to decide what is best now, what should I do next. If you could help, I'll appreciate it greatly.

Thanks for your time and ongoing support,
M.

[Quester]

Thanks for posting, I'd like to know more about this as it is the likely end goal for TRT.

[kelkel]

Not sure why they would skip the booster shot as it seems to be a successful protocol for getting T levels where they need to be.
Libido may be related, then again maybe not. So many things can cause libido issues that you just can't directly point at T levels.
Optimized T levels normally improve body composition. Low T levels are associated with obesity. Sorry to say I'd have to point toward diet as the issue here. Read this as well:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154787/

Maybe consider sticking this out a while as it takes time to dial things in. Improve your nutrition and training and set some short term goals for yourself. You'll get there! Plus, the holidays never make it easy!

[markwilliams]

Thanks for posting, I'd like to know more about this as it is the likely end goal for TRT.

Thanks. What would you like to know, exactly?

[markwilliams]

Not sure why they would skip the booster shot as it seems to be a successful protocol for getting T levels where they need to be.
Libido may be related, then again maybe not. So many things can cause libido issues that you just can't directly point at T levels.
Optimized T levels normally improve body composition. Low T levels are associated with obesity. Sorry to say I'd have to point toward diet as the issue here. Read this as well:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154787/

Maybe consider sticking this out a while as it takes time to dial things in. Improve your nutrition and training and set some short term goals for yourself. You'll get there! Plus, the holidays never make it easy!

Thanks for your honesty, I appreciate it. Since last September I started dieting and lifting again after a year and a half of letting myself go. I need to cultivate patience since I'm probably looking at a year of dieting, at least.

I have a question. From the data I have, Nebido peaks at around 600 ng/dL. Is this optimal or does it usually peak at higher levels? (for ex. 700/800).

[kelkel]

The peak will be different for everyone depending on how you individually metabolize testosterone . It's why some guys need shots every 8 weeks and others can go 10 plus. Main thing to look at though is your free T level. Total T doesn't really mean anything as FT is what works for us. Be sure you always check it on blood work. You could have a 5K total T level but if not enough of it is free then you will still have issues. Never a bad idea to know your shbg value as well.

[markwilliams]

Bloods on the second week show
Test 6.46 ng/mL /
Free Test 146.0 pg/mL
Estradiol: 57 pg/mL.

This is supposed to be my peak. Is estradiol too high?

[markwilliams]

Hello!

Some updates.

Bloods taken 9 days after my 6th Nebido injection, interval now reduced to 8-9 weeks.

Total Testosterone: 11.70 ug/L (interv. 2.49-8.36) -
Estradiol : 86 ng/L (interv. 11-43)

Is my estradiol dangerously high? I'm not taking any AI.

[kelkel]

Not necessarily. The standard estradiol test is really an incorrect assessment in men as it tends to read higher than normal due to mens E2 being lower and the test not being sensitive enough to provide accurate readings. Ask your doc to re-evaluate with a Sensitive E2-Assay and use this from this point forward for accuracy.

Dangerously high? No, even if it is accurate it's not in any way dangerous. E2 is always better a little higher than lower.

[markwilliams]

Not necessarily. The standard estradiol test is really an incorrect assessment in men as it tends to read higher than normal due to mens E2 being lower and the test not being sensitive enough to provide accurate readings. Ask your doc to re-evaluate with a Sensitive E2-Assay and use this from this point forward for accuracy.

Dangerously high? No, even if it is accurate it's not in any way dangerous. E2 is always better a little higher than lower.

Thanks. I emailed my endo and he basically agrees, also my E2 levels are half those in just a week, so that one are just relative to the peak.

It's weird though, because at nine weeks, before injecting, I felt fine (sex drive/libido) but after injecting and the following three weeks I've felt a considerable drop in libido and spontaneous erections.