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  1. #1
    Mr. Sparkle's Avatar
    Mr. Sparkle is offline Slinabolic Vet / Retired
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    Talking case study... IGF increases insulin sensitivity.

    Insulin -like growth factor I and impaired glucose tolerance.

    Dunger D, Yuen K, Ong K.

    University Department of Paediatrics, University of Cambridge, Cambridge, UK. [email protected]

    The effects of circulating insulin-like growth factor I (IGF-I) on glucose metabolism are well recognized. IGF-I is also important in maintaining beta-cell mass and regulating endogenous growth hormone (GH) levels. Low IGF-I levels could explain links between small birth size and the risk of developing type 2 diabetes mellitus in short, obese adults. In a recent prospective study, childhood insulin secretion was related to IGF-I levels and statural growth, whereas insulin sensitivity was related to early post-natal weight gain. Common genetic polymorphisms in the IGF1 gene have been linked to small birth size, post-natal growth and future diabetes risk, but these results have been inconsistent. Recent adult studies have demonstrated that lower baseline IGF-I levels predict the subsequent development of impaired glucose tolerance (IGT), type 2 diabetes and cardiovascular disease. Administration of low-dose GH therapy, at a dose that minimizes the lipolytic effects of GH and has the ability to increase IGF-I levels, enhances insulin sensitivity in young healthy adults and in GH-deficient adults and increases insulin secretion in individuals with IGT. Whether the administration of low-dose GH, recombinant IGF-I or combined IGF-I/IGF-binding protein 3 therapy prevents future development of IGT or type 2 diabetes in high-risk normoglycaemic and GH-deficient individuals merits further long-term studies. Copyright 2004 S. Karger AG, Basel.

    PMID: 15761241 [PubMed - in process]


    This is good, very good!!!!

  2. #2
    Mr. Sparkle's Avatar
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    Role of insulin-like growth factor iin maintaining normal glucose homeostasis.

    Role of insulin -like growth factor iin maintaining normal glucose homeostasis.

    Clemmons DR.

    Department of Medicine, UNC School of Medicine, Chapel Hill, NC 27599, USA. [email protected]

    Insulin-like growth factor I (IGF-I) has significant structural homology with insulin. IGF-I has been shown to bind to insulin receptors to stimulate glucose transport in fat and muscle, to inhibit hepatic glucose output and to lower blood glucose while simultaneously suppressing insulin secretion. However, the precise role of IGF-I in maintaining normal glucose homeostasis and insulin sensitivity is not well defined. Studies in patients with diabetes have shown that in insulin-deficient states, serum IGF-I concentrations are low and increase with insulin therapy. Similarly, administration of insulin via the portal vein results in optimization of plasma IGF-I concentrations. A patient with an IGF1 gene deletion was shown to have severe insulin resistance that improved with IGF-I therapy. Studies conducted in experimental animals have shown that if IGF-I synthesis by the liver is deleted, the animals become insulin-resistant, and this is improved when IGF-I is administered. Likewise, deletion of the IGF-I receptor in muscle in mice induces severe insulin resistance. Administration of IGF-I to patients with type 2 diabetes mellitus has been shown to result in an improvement in insulin sensitivity and a reduction in the requirement for exogenously administered insulin to maintain glucose homeostasis. A polymorphism in the IGF1 gene that has been shown to reduce serum IGF-I results in an increased prevalence of type 2 diabetes. Taken together, these findings support the conclusion that IGF-I is necessary for normal insulin sensitivity, and impairment of IGF-I synthesis results in a worsening state of insulin resistance. Copyright 2004 S. Karger AG, Basel.

    PMID: 15761237 [PubMed - in process]

  3. #3
    symatech's Avatar
    symatech is offline Retired Moderator
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    It is interesting to say the least. I'm curious mr. sparkle as to what your thoughts are on the evidence that increased igf-1 levels lead to prostate cancer. For those who choose to use these drugs, where does the balance lie for igf-1 dosing? hard to explain what I'm thinking really, but if we consider that lower than baseline levels of igf-1 not only lead to IGT but advanced metastatic disease (spreading of cancer cells) yet high levels lead to prostate cancer, where is the medium? I'm just trying to learn as much about this as I can. thanks for the input

  4. #4
    Mr. Sparkle's Avatar
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    That is a good question..... id like to know too....

  5. #5
    Tuggy's Avatar
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    Excellent post. Definetly good info. I guess you should truly be careful if combining slin w/IGF.

  6. #6
    Mr. Sparkle's Avatar
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    IGF-1 and prostate cancer.

    IGF-1 and prostate cancer.

    Roberts CT Jr.

    Department of Pediatrics, NRC5, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

    By virtue of their potent proliferative and anti-apoptotic effects, the insulin -like growth factors (IGFs) have been the subject of long-term scrutiny for their role in tumorigenesis. With regard to prostate cancer in particular, IGF-1 has been shown to stimulate the proliferation of human prostate epithelial cells in culture and to be necessary for normal growth and development of the rat and mouse prostate. Epidemiological studies have established a link between high circulating serum IGF-1 levels and the risk of later developing advanced prostate cancer, and overexpression of IGF-1 in the prostate basal epithelial layer of transgenic mice results in prostate adenocarcinoma that is similar to human disease. Thus, IGF-1 action appears to be important for prostate cancer initiation. On the other hand, decreased IGF action, subsequent to the down-regulation of IGF-1 receptor expression, is associated with advanced, metastatic disease. This decrease in IGF-1 receptor may confer a survival advantage to prostate cancer cells that have entered the circulation by making them resistant to the differentiative effects of IGF-1 at metastatic sites such as bone. The molecular mechanisms that effect IGF-1 receptor down-regulation appear to involve novel oncogenic functions of the Wilms' tumour suppressor, as well as novel actions of the androgen receptor.

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    PMID: 15562830 [PubMed - indexed for MEDLINE]

  7. #7
    Mr. Sparkle's Avatar
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    Quote Originally Posted by Tuggy
    Excellent post. Definetly good info. I guess you should truly be careful if combining slin w/IGF.
    Yes that is for sure....
    plus it looks like IGF will cuase your natural insulin sensitivity to increase, so if you were getting use to slin... IGF might make it work well again...

  8. #8
    Tuggy's Avatar
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    On the other hand, decreased IGF action, subsequent to the down-regulation of IGF-1 receptor expression, is associated with advanced, metastatic disease.
    Seems that you are ****ed if you do and ****ed if you don't. I guess if you must die, you might as well look good.

  9. #9
    jwillfcsl is offline Associate Member
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    there is at least one study claiming that nearly anything will cause some kind of cancer, who can really say, there are people who smoke there entire life and do not get cancer, seems like it is all based on the individual

  10. #10
    abstrack's Avatar
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    interesting study. So this is just IGF1 not igf-1r3?

    also it's kind of weird that igf-1 increases insulin sensitivity but HGH has a negative effect on insulin yet they are both like kissiing cousins
    abstrack@protonmail.com

  11. #11
    JohnnyB's Avatar
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    Quote Originally Posted by Mr. Sparkle
    Yes that is for sure....
    plus it looks like IGF will cuase your natural insulin sensitivity to increase, so if you were getting use to slin... IGF might make it work well again...
    That's why it's good to run slin then LR3 IGF-1 to restore insulin sensitivity

    JohnnyB

  12. #12
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    The key wor(s) in that study are cancer cells, AAS increases IGF-1 as well so the same could apply

    JohnnyB

  13. #13
    Mr. Sparkle's Avatar
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    Very true, all epithelal cells are mytotic, so there is always a chance of irregular growth (cancer)

    One more positive side to IGF, so becoming diabetic is a lot harder

  14. #14
    bluethunder is offline Anabolic Member
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    Quote Originally Posted by symatech
    It is interesting to say the least. I'm curious mr. sparkle as to what your thoughts are on the evidence that increased igf-1 levels lead to prostate cancer. For those who choose to use these drugs, where does the balance lie for igf-1 dosing? hard to explain what I'm thinking really, but if we consider that lower than baseline levels of igf-1 not only lead to IGT but advanced metastatic disease (spreading of cancer cells) yet high levels lead to prostate cancer, where is the medium? I'm just trying to learn as much about this as I can. thanks for the input
    Past Rundman studies showed IGF values of around 350nanograms the amount of a 20-30yr old still showed increased lean muscle, decrease fat and increases of bone density. The bottom line is attempting to keep within a natural level to minimize all those possible sides like cancer. Suprapyhsiological high doses are just not normal in the human body. The doses you take and frequency can only be varified by blood work.

  15. #15
    LB55blitz's Avatar
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    Quote Originally Posted by abstrack
    interesting study. So this is just IGF1 not igf-1r3?

    also it's kind of weird that igf-1 increases insulin sensitivity but HGH has a negative effect on insulin yet they are both like kissiing cousins

    my thoughts exactly. really boggles the mind.

  16. #16
    jgg1221 is offline Member
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    Quote Originally Posted by LB55blitz
    my thoughts exactly. really boggles the mind.
    thats all the chemistry

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