08-03-2005, 03:39 PM #1
IGF1 - Using a virus as a genetic vehicle
This part is interesting to me because it talks about using a virus as a vehicle to deliver IGF1 over long periods. It's working in mice so far.
The results of this study are similar to other studies where IGF-1 was injected directly into muscle tissue, resulting in increases in size and strength of experimental animals. Using a virus as a genetic vehicle has an advantage over simply injecting the growth factor. The effects of a single viral treatment last significantly longer (months if not years) because the muscle cell itself is constantly overproducing its own IGF-1 from injected DNA.
The fact that the IGF-1 produced by the muscle of these mice did not reach the blood stream is interesting. Systemic injections of IGF-1 have not been successful in inducing this kind of anabolic effect in humans. In addition, IGF-1 produced by the liver is genetically different than that produced by muscle tissue. It could be that providing additional DNA for the muscle to produce it’s own IGF-1 is the key to achieving anabolic and rejuvenative effects specifically in skeletal muscle.
08-03-2005, 05:04 PM #2
Sounds pretty interesting, I just wonder how controllable it is - seeing as viruses are quite often hard to treat........
08-03-2005, 08:56 PM #3supersteve Guest
they are talking about igf-1 though not lr3 right?
08-04-2005, 12:13 AM #4Originally Posted by supersteve
08-04-2005, 12:18 AM #5Originally Posted by Duke of Earl
08-04-2005, 01:13 AM #6Associate Member
Originally Posted by Seattle Junk
- Join Date
- Apr 2005
08-04-2005, 06:20 AM #7
Its called gene doping, and I dont believe the virus works exactly like a standard retrovirus where it encodes itself in the host's DNA and causing it to make viral DNA + viral proteins. I am pretty sure with gene doping it just delivers the target gene to the cells and your immune system eventually destroys the virus.
08-04-2005, 08:52 AM #8immune system eventually destroys the virus.
08-04-2005, 09:30 AM #9
I am pretty sure your white blood cells eat the virus and digest it. Once you have a virus does not mean that you always have it, you dont become "immune" to it but your body produces antibodies that bind to a site on the virus so macrophages and phagocytes and eat it.
08-04-2005, 11:16 AM #10Originally Posted by vestax
I can't wait for this technology to finally become usable for humans! I would love to take one shot a year and be jacked as hell...
08-04-2005, 01:37 PM #11
man I wouldnt ever **** around with this shit. imagine the consequences if something went wrong
08-04-2005, 01:50 PM #12Junior Member
Originally Posted by vestax
- Join Date
- May 2005
yea you will become like Ronnie
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