08-27-2005, 03:57 PM #1
IGF-2 causes small intenstinal growth?
I'm going by memory from what I've read over the past month or so. Now the main reason why people get "roid gut" is from the liver producing IGF-2 (or it's converted from IGF-1?)? Since the small intestines have many IGF-2 receptors, it grows larger? Is this correct? So how would a high amounts of l3 IGF-1 cause this undesirable side effect, if it all?
I'm a few weeks away from starting a month run of l3 IGF-1 with test prop. I'm thinking 60mcgs PWO (split morn/eve on off days). I just want to cover everything and get stuff settled in my mind.
08-27-2005, 04:48 PM #2Originally Posted by Seattle Junk
08-27-2005, 04:54 PM #3Originally Posted by Captain Fantastic
08-27-2005, 07:23 PM #4Originally Posted by Seattle Junk
I do 15 per muscle side per day. either PWO or in the PM about the same time. I got the roid gut. lasted at least a month PC before I started 30/day on 2nd cycle and it has subsided. I throw a shake in bed with me so in the AM I can take a drink and go back to sleep. The first run was with european AAS-primobolan -300 mg/wk, equipose 200 mg/wk, sustanon 200 mg/wk. Going to throw in some tren . on the next one and will be on HGH which I just started, 1st time. I see limited use of the Long R. once per cycle, once PC, max. Do you know what to do about the roid gut? how permanent is it? is it a sympton of hypo ? thankx
Last edited by Captain Fantastic; 08-27-2005 at 07:31 PM.
08-27-2005, 07:34 PM #5
I wouldn't split doses until I was using 80mcg and as most of you already know, injecting into the worked muscles bilaterally, is not needed with LR3 IGF-1.
08-27-2005, 08:11 PM #6Originally Posted by JohnnyB
08-27-2005, 08:15 PM #7Originally Posted by Seattle Junk
08-28-2005, 08:34 AM #8Originally Posted by Seattle Junk
The best way I can describe it is it feels like hunger panes. No anti-inflamatories, just finesteride and some herbs and vitamins - milk thistle, aritichoke, mult. vitamin-no iron, vit. e, cranberry extract, calcium, zinc, chrom pic., mult. amino acid, and saw pawmetto. I come off the finesteride while taking a nandrolene derivative: ie: tren .
Does anyone see anything incompatible with the above?
Does anyone know the symptoms of hypo? what it is?
All response's kindly appreciated.
Last edited by Captain Fantastic; 08-28-2005 at 08:38 AM.
08-28-2005, 05:14 PM #9
oops, i did it again
08-28-2005, 05:58 PM #10
I bet roid gut puts a few extra pounds on your squat?
08-29-2005, 02:03 AM #11Associate Member
- Join Date
- Mar 2005
08-29-2005, 02:49 PM #12Originally Posted by seatle junk
the liver does not produce igf 2
nor is transformed from igf 1.
IGF-1 is secreted by the liver
IGF-2 is secreted by the brain, kidney, pancreas and muscle.
The IGF-2 receptor only binds IGF-2 and acts as a "clearance receptor" - it activates no intracellular signalling pathways, functioning only as an IGF-2 sequestering agent and preventing IGF-2 signalling.
"Insulin -like growth factor (IGF)-2 is overexpressed in hepatocellular carcinoma and accompanying dysplastic lesions. IGF-2 signalling is mediated through IGF-1 receptor (IGF-1R), while mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF-2R) controls pericellular levels of free IGF-2"
British Journal of Cancer (2003) 88, 733-739.
focal overexpression of insulin-like growth factor 2.
N Sedlaczek1,2, A Hasilik3, P Neuhaus4, D Schuppan5 and H Herbst1
1.-Institute of Pathology, University of Muenster, Muenster, D-48129, Germany
2.-Department of Gastroenterology and Hepatology, Klinikum Benjamin Franklin, Free University of Berlin, Berlin, Germany
3.-Institute of Physiological Chemistry, Philipps-University, Marburg, Germany
4.-Department of Surgery, Charitè, Campus Virchow-Klinikum, Humboldt-University, Berlin, Germany
5.-Department of Gastroenterology and Hepatology, Friedrich-Alexander-University, Erlangen, Germany
Cohen, Pinchas, et al. "Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial". Journal of Clinical Endocrinology and Metabolism, Vol. 73, No. 2, 1991, pp. 401-07
08-29-2005, 02:58 PM #13
There’s a trainer at my gym(says he’s going for his pro card) that has the biggest GH/IGF Gut.
This freak is about 5’8” 275 lbs and about 6% but he looks pregnant. It’s horrible. This guy is a mess. He wears tank tops and you can see the lumps where he just injected his biceps, Delts and triceps. To top it off, the big bicep vein on both arms are completely scarred up. I mean fresh red scares. He must be injecting
something into his veins. Don’t get me wrong, this guy is a monster but the dude need to clean his act up…
I bet this nut never cycles IGF.
Yo Freak, You Cycle? No, I don’t own a bike man….ha!
08-29-2005, 03:40 PM #14Originally Posted by oswaldosalcedo
08-30-2005, 03:31 PM #15
thank you seattle.
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