what can supress igf-1 during pct (letro)

**dogfight** · 09-04-2005, 09:30 PM

do you know if letro will supress your igf-1 levels? of any other anti -estrogens

can any thing elese?

***JohnnyB*** · 09-04-2005, 10:01 PM

Yes it will as with all drugs that are made for breat cancer

JohnnyB

**Slic4788** · 09-04-2005, 10:56 PM

Not letro but nolva, yes.

**HumanPerfection1** · 09-04-2005, 11:18 PM

nolva deff

**rodge** · 09-05-2005, 05:10 AM

letro and aromasin are actually raising igf-1 levels.

-rodge

**dogfight** · 09-05-2005, 07:12 AM

ok so thats the good thing about it but i dont understand if letro is a anti-aromatise why is there a rebound affect? an if i take Ldex to fight the rebound will that lower my igf-1 or just not affect it??
thanx all!!

**reveremuscle** · 09-05-2005, 10:08 AM

Going to start IGF tuesday, last dose of 50mg clomid was friday, should I be all set?

**Slic4788** · 09-05-2005, 06:20 PM

Originally Posted by dogfight

ok so thats the good thing about it but i dont understand if letro is a anti-aromatise why is there a rebound affect? an if i take Ldex to fight the rebound will that lower my igf-1 or just not affect it??
thanx all!!

taper off the letro slowly to avoid the rebound effect.

supersteve · 09-05-2005, 10:45 PM

There's really no consensus either way.
In one study letro raised igf-1 (older women) and in another (teenage boys) it was lowered slightly.
Arimidex also shows conflicting results.

Tamoxifen certainly seems to lower igf-1. But it does this by suppressing your endogenous GH release. So if you're injecting GH this really isn't of any concern.