09-06-2005, 09:53 AM #1Member
- Join Date
- Jan 2005
IGFBP-3 is it better then lr3 igf-1?
09-06-2005, 10:02 AM #2
I doubt it.
Human Insulin -Like Growth Factor Binding Protein-3 (hIGFBP-3) is a 264 amino acid protein that is one of the six classical IGF binding proteins that play an important role in stabilizing and regulating the activity of IGFs in vivo. Human IGFBP-3 is a 40-44 kDa glycoprotein that is the most abundant IGFBP in serum and milk. It is produced by non-parenchymal hepatic cells and circulates in serum, binding IGF-I or IGF-II in conjunction with an acid labile subunit (ALS) to form a 150 kDa circulating complex at a serum concentration of about 100 nM. Free IGF-I has a half-life of ~10 min in serum. This can be increased to ~25 min if bound to IGFBP-3 and to ~15 h if complexed with IGFBP-3 and ALS (Rechler, MM & Clemmons, DR (1998) TEM 9, 176-183).
09-06-2005, 12:00 PM #3
LR3 binds poorly to IGF-1 BP, that's why it's half-life is around 6 hours
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