09-30-2005, 09:44 AM #1Associate Member
- Join Date
- May 2005
which would produce better results.
IGF/SLin together for 4 weeks OR
IGF for 4 weeks then SLin for 4 weeks
09-30-2005, 10:43 AM #2
Have you done either one? You really need to try them alone first so you know how your body will react. To answer your question doing both at the same time is better. But you need to get your diet down first so you can figure out how to adjust your food intake for the slin. IGF is easy to deal with, slin can be tricky..
This is like your 2nd question about this. You need to get busy brother
Last edited by Puffader; 09-30-2005 at 10:45 AM.
09-30-2005, 10:53 AM #3Originally Posted by Puffader
09-30-2005, 11:12 AM #4Associate Member
- Join Date
- May 2005
My last thread asked about the combination of IGF/slin and how to time them if taken together..THis thread is asking which would yield better results, because I have read threads on both and instead of taking advice from other threads I rather some direct input from some of the vets who use these compounds together. YEs I have used slin numerous times. But this is my first experience with the IGF..So any input on which 2 scenarios is best would be greatly appreciated. I take this stuff seriously like many of you and Im trying to be smart about things instead of diving head first like some..
09-30-2005, 03:59 PM #5
when used together it will give you more results then either one alone. but by running it after each other and repeating this for quite some time you will constant have an anabolic substance in your body and thus give you more results in the long run.
10-02-2005, 05:44 PM #6Originally Posted by rodge nl.
10-02-2005, 05:55 PM #7
Something to think about
Insulin-like growth factor-I and more potent variants restore growth of diabetic rats without inducing all characteristic insulin effects.
Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Ballard FJ
Cooperative Research Centre for Tissue Growth and Repair, Adelaide, Australia.
The effects of graded doses of insulin -like growth factor-I (IGF-I) and two variants which bind poorly to IGF-binding proteins were investigated in 160 g streptozotocin-induced diabetic rats. The two variants were the truncated form, des(1-3)IGF-I, and another with arginine at residue 3 and an N-terminal extension, termed LR3-IGF-I. The peptides were infused via mini-osmotic pumps. Reference groups received either vehicle or insulin (30 i.u. per day). Treatment led to a marked dose-dependent increase in growth rate and nitrogen balance. The highest dose (695 micrograms/day) of IGF-I increased body weight by 48.1 +/- 1.7 g/7 days, compared with 11.0 +/- 2.8 g/7 days for the vehicle-treated group. The two variants were 2.5-3 times more potent than IGF-I in restoring growth. The insulin-treated group gained more weight (64.5 +/- 1.6 g/7 days), but the added gain was fat (92.5 +/- 4.8 g of fat/kg carcass wet wt., compared with 32.2 +/- 2.1 for all other groups) rather than protein. All peptides increased muscle protein-synthesis rates and RNA levels by up to 50%, with IGF-I the least potent. These high doses of IGFs did not decrease either the glucosuria or the daily excretion rate of N tau-methyl-histidine (N tau-MH). On the other hand, insulin treatment markedly decreased both glucosuria (from 82.7 +/- 5.4 to 4.5 +/- 3.3 mmol/day) and N tau-MH excretion (from 9.3 +/- 0.3 to 7.1 +/- 0.4 mumol/day per kg). This experiment shows that, although IGF-I and variants can restore growth in diabetic rats, other insulin-dependent metabolic processes in liver, muscle and adipose tissue are not restored.
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