HGH Organ Growth

[dans]

Does anyone know if any studies have been done on the effects of HGH on organ size? I really don't want my organs getting any bigger, it can't be very healthy. Does this only happen at higher dosages or long-term use? Just haven't been able to find much information on this subject. Seems some people say it does, other say it doesn't.

Anyone?

[Pinnacle]

I've haven't seen a study on that specifically.But it's a well known that athletes have larger organs than the average person.

~Pinnacle~

[HumanPerfection1]

gh and insulin is really what cause's organ growth, igf-1 and insulin will do the same, its basically juice, insulin and gh

[JohnnyB]

HGH can increase IGF-II which causes organ growth, at what dose, I'd say that's on an induvidual bases

JohnnyB

[HumanPerfection1]

HGH can increase IGF-II which causes organ growth, at what dose, I'd say that's on an induvidual bases

JohnnyB

perfectly said, In other words its depends on a person's genetic dispostion, your the man johnnyb

[Seattle Junk]

Does anyone know if any studies have been done on the effects of HGH on organ size? I really don't want my organs getting any bigger, it can't be very healthy. Does this only happen at higher dosages or long-term use? Just haven't been able to find much information on this subject. Seems some people say it does, other say it doesn't.

Anyone?

Jumbo sized organs.... Like Johnny said, it's the liver producing IGF-2 that causes "roid gut", enlargement of the small instestines. I've read about this happenning in BBs using larger amounts of GH.

[Gear]

I would say both high doses and long term use can lead to side effects as such.

-Gear

[Pinnacle]

It's well known that high doses of HGH can cause the distended belly via IGF-2,BUT what "dans" is asking is if can cause growth in the heart,liver,kidneys ect...not just the distended belly issue.
I haven't seen any studies that I can recall,but I'm sure they're out there.


~Pinnacle~

[IBdmfkr]

Women have told me I'm heartless, so I guess I don't have to worry bout GH sides.

[simm]

Acromegalic patients have enlarged heart,spleen,liver and kidneys due to excessive hgh being produced at high levels over prolonged periods of time....ie...Long term hgh use at excessive dosages...Excessive for you maybe somewhat moderate for someone else...As johnnyb said,it is individuality with these things!! Good luck..

[Robinson]

I reckon igf-1 will leave you with an enlarged heart. In acromegalic patients this wears partly off after igf-levels are normalized after treatment.

I've seen an study done on athletes where after one month of high dosed GH there was a clear growth in left ventricular mass (0.06 mg/kg/day). Not all heartgrowth is bad but these in acromegalic patients leaves them with less bloodpumpingcapacity

They say 1 IU equates to +/- 5mcgs igf. So 80mcgs = 16 IU.

But we don't know for sure...I wish we did

[Seattle Junk]

I reckon igf-1 will leave you with an enlarged heart. In acromegalic patients this wears partly off after igf-levels are normalized after treatment.

I've seen an study done on athletes where after one month of high dosed GH there was a clear growth in left ventricular mass (0.06 mg/kg/day). Not all heartgrowth is bad but these in acromegalic patients leaves them with less bloodpumpingcapacity

They say 1 IU equates to +/- 5mcgs igf. So 80mcgs = 16 IU.

But we don't know for sure...I wish we did

Where did you get that data/info?

[JohnnyB]

It's well known that high doses of HGH can cause the distended belly via IGF-2,BUT what "dans" is asking is if can cause growth in the heart,liver,kidneys ect...not just the distended belly issue.

~Pinnacle~

Where did he ask that, he said "organs" intestines are an organ and they can grow, I don't see any specific question about liver, heart or kidneys.

JohnnyB

[Robinson]

Where did you get that data/info?

Well, I've read more than once on various places 1 IU of GH roughly compares to 5mcgs of igf strenghtwise but that's nothing scientific (of course it's not possible to completely compare both substances).

[Seattle Junk]

Well, I've read more than once on various places 1 IU of GH roughly compares to 5mcgs of igf strenghtwise but that's nothing scientific (of course it's not possible to completely compare both substances).

On message boards like this? OMG, don't use that info as the truth, please. Info on internet message boards is like test pilot data that may or may not work or be true. Too many factors without controls. Until it's verified by a trusted source or clinical studies, it's make your best judegemnt.

[Robinson]

On message boards like this? OMG, don't use that info as the truth, please. Info on internet message boards is like test pilot data that may or may not work or be true. Too many factors without controls. Until it's verified by a trusted source or clinical studies, it's make your best judegemnt.

I know. Yes it is userinformation. But it's the only info available. And if you look at the results you get from igf it might be a quite good estimation. Still they remain different compounds...

[oswaldosalcedo]

Well, I've read more than once on various places 1 IU of GH roughly compares to 5mcgs of igf strenghtwise but that's nothing scientific (of course it's not possible to completely compare both substances).

this way is scientific:

"High Dose Growth Hormone Exerts an Anabolic Effect at Rest and during Exercise in Endurance-Trained Athletes
M. L. Healy, J. Gibney, D. L. Russell-Jones, C. Pentecost, P. Croos, P. H. Sönksen and A. M. Umpleby
Department of Diabetes and Endocrinology, GKT School of Medicine, St. Thomas Hospital, London, United

r-hGH-treated

------------------ Baseline --------- 1wk-----------4 wk--------- /Placebo-
IGF-I (nmol/liter) 24.6 ± 3.0 / 89.6 ± 12.21-- 106.3 ± 16.41/ 25.8 ± 2.7-- 25.4 ± 2.7-- 25.2 ± 2.6
fT3 (pmol/liter) 5.1 ± 0.3 6.0 ± 0.12 6.1 ± 0.22 4.8 ± 0.2 4.9 ± 0.2 4.8 ± 0.1
fT4 (pmol/liter) 15.5 ± 1.5 11.5 ± 1.02 10.6 ± 0.92 15.8 ± 1.6 15.6 ± 1.7 15.8 ± 1.5
Testosterone (nmol/liter) 18.3 ± 3.2 18.5 ± 3.4 18.5 ± 3.3 16.7 ± 2.6 16.3 ± 2.6 16.4 ± 2.2
Glucose (mmol/liter) 4.7 ± 0.3 5.5 ± 0.5 5.3 ± 0.2 4.5 ± 0.4 4.2 ± 0.2 4.4 ± 0.3
Insulin (mU/liter) 7.9 ± 1.6 22.6 ± 3.92 16.0 ± 9.32 6.0 ± 0.3 5.6 ± 1.9 9.3 ± 2.4
HOMA IR 1.4 ± 0.2 5.1 ± 1.02 3.3 ± 0.62 1.1 ± 0.4 1.0 ± 0.3 1.6 ± 0.5
Total cholesterol (mmol/liter) 4.3 ± 0.3 4.0 ± 0.5 4.1 ± 0.3 3.4 ± 0.3 3.3 ± 0.3 3.5 ± 0.6
Triglyceride 1.1 ± 0.2 2.0 ± 0.5 1.3 ± 0.1 0.6 ± 0.1 0.7 ± 0.1 0.5 ± 0.1
LDL cholesterol (mmol/liter) 2.6 ± 0.3 2.2 ± 0.3 2.3 ± 0.3 1.6 ± 0.4 1.6 ± 0.3 1.6 ± 0.5
HDL cholesterol (mmol/liter) 1.2 ± 0.1 1.0 ± 0.1 1.1 ± 0.1 1.5 ± 0.1 1.5 ± 0.1 1.7 ± 0.2
Body weight (kg) 74.4 ± 1.1 76.5 ± 1.72 77.9 ± 1.62 74.9 ± 3.4 74.9 ± 3.4 74.7 ± 3.3
Lean body mass (kg) 57.6 ± 1.1 61.0 ± 1.22 61.6 ± 2.5 61.8 ± 2.4
Total body fat (kg) 11.4 ± 1.4 11.6 ± 1.7 9.8 ± 1.9 10.1 ± 2.0
Trunk fat (kg) 4.7 ± 0.7 4.5 ± 0.9 2.8 ± 0.9 2.8 ± 0.9

There was no change in IGF-I levels in the placebo-treated group throughout the observation period. In contrast, in the r-hGH-treated group, IGF-I levels rose markedly, reaching levels outside the physiological range (P < 0.001; Table 2 ). These changes occurred within 7 d of commencing r-hGH administration and did not change further over the remaining 21-d period of r-hGH administration


and:
organ growth from igf1,igf2 any.............:


BODY GROWTH, CARCASS COMPOSITION, AND ENDOCRINE
CHANGES IN LAMBS CHRONICALLY TREATED WITH
RECOMBINANTLY DERIVED INSULIN-LIKE GROWTH FACTOR-1

YVETTE H. COTTAM, HUGH T. BLAIR, BRIAN W. GALLAHER,
ROGER W. PURCHAS, BERNHARD H. BREIER, STUART N. MCCUTCHEON, AND PETER D. GLUCKMAN

male sheeps were treated for 8 weeks with either 50 mcg/kg body wt/8 hourly SC insulin-like growth factor-I (IGF-I) (n = 10) or with saline (n = 9). IGF-I treatment increased plasma IGF-I from 235 + 17 to 347 + 16 rig/ml (P < 0.001).

suggesting that in the well fed animal with an intact somatotropic
axis IGF-I treatment at doses which double plasma IGFI
does not enhance somatic growth performance. However, the
marked splenomegaly shows the sensitivity of splenic growth to
systemic IGF-I. The suppression of insulin with chronic IGF-I
treatment was accompanied by hyperglycaemia-this may explain
in part the lack of a significant anabolic response and may
limit the utility of IGF-I therapy unless higher doses with
insulin-like effects are used. (Endocrinology 130: 2924-2930)….

…..In conclusion, exogenous IGF-I administered at physiological
doses did not exert marked effects on body wt
gain, carcass dimensions, or body composition in intact,
growing, and well-fed yearling sheep. It had some marked
endocrine and metabolic effects, however, including
suppression of plasma insulin, IGFBP-2, and induced
hyperglycaemia. Marked splenomegaly was also noted.
These changes must be borne in mind in considering any
possible therapeutic use of IGF-I. While IGF-I treatment
in this study did not cause a major somatogenic response
in well fed normally growing animals, higher doses of
IGF-I may be more effective. However, under more severe
conditions such as undernutrition, when GH resistance
occurs (44) IGF-I is a more effective anabolic agonist…..

Organ- control- igf 1 treated

Heart 232.0 +/- 11.0 ------- 230.4 +/ 10.4
Liver 1005.9 +/- 48.5 ----- 1027.0 +/- 45.9
Spleen 78.8 +/- 4.6 ------ 114.6 +/- 4.4 (50 %)
Lungs 502.6 +/- 29.9 ------ 515.1+/- 28.3
Kidneys 131.8 +/- 5.3 ------ 145.6 +/- 5.0

[Seattle Junk]

Is this saying the lamb's spleen doubled in size?

[oswaldosalcedo]

no, 50 %.
half grow.
example 70 cm to 105 cm.
100 % must be 70 cm to 140 cm.

[Seattle Junk]

no, 50 %.
half grow.
example 70 cm to 105 cm.
100 % must be 70 cm to 140 cm.

Right, I see...Is an enlarged spleen a health problem? I know enlarged organs are usually not good, especially the heart.

[gijoela]

To all you guys who like HGH is da ____!

UCLA just completed a large scale study that compared HGH therapy to Deca or otherwise known as Nandrolone (sp?).

The study included 400 participants. 38% of the people on HGH had to discontinue due to adverse side effects. O% discontinued Deca treatment.

As far as gains are concerned (muscle mass) the results were surprising and should deflate the HGH miracle dream theories.

The muscle mass gains in the study group were nearly identical with NO reported side effects in the DECA group.

The dosage of DECA used in the study was 150 milligrams TWICE weekly.

The bottom line, you can piss away THOUSANDS of dollars and cause yourself permanent disfigurement or you can simply use Deca for about $ 16 bucks a dose. Nobody so far has mentioned that HGH has caused some people to become Diabetic as it throws off your insulin .

There is a much safer growth hormone in clinical trials that really causes fat lose without the dangers of the current HGH.

It's your choice.

[oswaldosalcedo]

I have always thought that hgh is not the holy Grail.

[oswaldosalcedo]

Right, I see...Is an enlarged spleen a health problem? I know enlarged organs are usually not good, especially the heart.

well.............really, i dont know about very big spleen, but who knows?

is no beautiful lol....

beautiful belly !

[Pinnacle]

Where did he ask that, he said "organs" intestines are an organ and they can grow, I don't see any specific question about liver, heart or kidneys.

JohnnyB

Exactly!!The key word is "ORGANS".And yes the intestines are an "ORGAN".Doesn't take much to understand his question.


~Pinnacle~

[Robinson]

"------------------ Baseline --------- 1wk-----------4 wk--------- /Placebo-
IGF-I (nmol/liter) 24.6 ± 3.0 / 89.6 ± 12.21-- 106.3 ± 16.41/ 25.8 ± 2.7-- 25.4 ± 2.7-- 25.2 ± 2.6"

Don't know how to convert nmol/liter to mcgs of igf in the whole body. Think it's an substance specific conversion. Also don't know how much liters of blood there are +/- in a bb but that could be found out I guess.

[oswaldosalcedo]

the levels of igf can be 250 mcg/l to 500 mcg/l (post hgh).

[Seattle Junk]

To all you guys who like HGH is da ____!

UCLA just completed a large scale study that compared HGH therapy to Deca or otherwise known as Nandrolone (sp?).

The study included 400 participants. 38% of the people on HGH had to discontinue due to adverse side effects. O% discontinued Deca treatment.

As far as gains are concerned (muscle mass) the results were surprising and should deflate the HGH miracle dream theories.

The muscle mass gains in the study group were nearly identical with NO reported side effects in the DECA group.

The dosage of DECA used in the study was 150 milligrams TWICE weekly.

The bottom line, you can piss away THOUSANDS of dollars and cause yourself permanent disfigurement or you can simply use Deca for about $ 16 bucks a dose. Nobody so far has mentioned that HGH has caused some people to become Diabetic as it throws off your insulin .

There is a much safer growth hormone in clinical trials that really causes fat lose without the dangers of the current HGH.

It's your choice.

I assume none of those guys have gfs or wifes? 300mgs deca only per week....

GH with AAS (+ slin as well) is the key to using GH for max muscle gain. Not GH by itself. It's comparing a AAS against a growth factor only. The synergystic effect is the key. How much GH was used? How was it dosed? That study is stupid IMO.

[oswaldosalcedo]

I assume none of those guys have gfs or wifes? 300mgs deca only per week....

GH with AAS (+ slin as well) is the key to using GH for max muscle gain. Not GH by itself. It's comparing a AAS against a growth factor only. The synergystic effect is the key. How much GH was used? How was it dosed? That study is stupid IMO.

excuse me seattle but imo

hgh is worthless.
t3 more fatless
and aas
more mass

.......................in poem.............lol...........

hgh too much $$$$$$$$$

[Seattle Junk]

excuse me seattle but imo

hgh is worthless.
t3 more fatless
and aas
more mass

.......................in poem.............lol...........

hgh too much $$$$$$$$$

Ok, what's your opinion on r3IGF-1?

[oswaldosalcedo]

Ok, what's your opinion on r3IGF-1?

good question !


...........pondering.

[Sayker]

I keep hearing people say this stuff is useless... Keep in mind that there are alot of fakes out there. Also Ive seen alot of questions on here, from people currently on GH, that they should have researched and answered thereself months before ever startin. Especially when it comes to reconstituting it, I wonder how many people ruin there GH from mis handling it and then bitch that it doesnt give them results.

Deca by itself? lets see how those guys stack up 6 months post cycle, GH is slow, its building new little baby muscle fibers that are molded over months spent in the gym. Ive done 3 cycles of juice and I cant stand comin off the stuff. Who wants to hit there max potential only to lose half of the 15 lbs you put on, yall know the feeling, you're in the gym hardcore PCT trying to save every last bit of that new muscle you can, but week by week you get a little weaker untill your finally left only a wee bit bigger than you were before. Id rather take 6 months of GH and slowly pack on 15 lbs of solid lean muscle that I can hold onto. Each mans choice though we all have are own goals in the gym, mines permanent muscle not water weight.

Only side effects ive seen on jino is that my receding hairline has started to dissappear, my hair is thicker, cant seem to stop losing body fat and Im pretty sure it is playing a huge role in helping to speed up my recovery from two surgeries and a broken back.... ohhh yeah and my eyesight seems to be gettin better too. The other day I walked around all day thinkin I had my contacts got home to take em out and they werent in there, now its not all the way better better but it has def. improved.

I guess I could trade all that for a bottle of deca cuz it is alot cheaper, minus the cost of cialis/viagra. 3 grand even though Im a broke as college kid, doesnt seem like that much money. Shit a year and a half ago I spent 1500 on a primo anabolic cycle only to go from 184 to 193 over a 3 month period. Who hasnt sunk at least 3 grand into a vehicle, why not spend that next 3 on a permanent change to your body. Im severly limited by my genetics, but I think I found the cure. This time when I hit 190 I plan on stayin there.

[JohnnyB]

Exactly!!The key word is "ORGANS".And yes the intestines are an "ORGAN".Doesn't take much to understand his question.


~Pinnacle~

Re-read what you said, you make it sound like he only asked about the heart, kidneys and liver. The only studies I've read are about the intestines, so if you have some about the afore mentioned organs. Can you post them? I'd like to read them, cause as far as I know the intestines are the only organ that growing from IGF-II, but if you have other info, don't keep it to yourself, share

JohnnyB

[Pinnacle]

Re-read what you said, you make it sound like he only asked about the heart, kidneys and liver. The only studies I've read are about the intestines, so if you have some about the afore mentioned organs. Can you post them? I'd like to read them, cause as far as I know the intestines are the only organ that growing from IGF-II, but if you have other info, don't keep it to yourself, share

JohnnyB

Apparently you were so overly anxious to attack my post,you haphazardly overlooked my initial post.I urge you to read it.
Why they attack?I didn't quote you or suggest anything of the nature that your post was off.I merely stated dans was looking for info pertaining to growth of ORGANS via HGH usage.Due note at the end of naming organs I used ECT..


Good Evening...


~Pinnacle~

[Puffader]

Moderators are getting evil around here. Evil doers..

[oswaldosalcedo]

Re-read what you said, you make it sound like he only asked about the heart, kidneys and liver. The only studies I've read are about the intestines, so if you have some about the afore mentioned organs. Can you post them? I'd like to read them, cause as far as I know the intestines are the only organ that growing from IGF-II, but if you have other info, don't keep it to yourself, share

JohnnyB

I think that you only hear or read what agrees you (and only you),there is anger in your words,
Get up-to-date !
growth of organsssssss (plural) is from igf1,igf2 and
so on,(or you are in love, only with igf 2?)...............lol.
again.....
the liver does not produce igf 2
nor is transformed from igf 1.
IGF-1 is secreted by the liver
IGF-2 is secreted by the brain, kidney, pancreas and muscle.
The IGF-2 receptor only binds IGF-2 and acts as a "clearance receptor" - it activates no intracellular signalling pathways, functioning only as an IGF-2 sequestering agent and preventing IGF-2 signalling.
IGF-1 and IGF-2 are encoded by two different genes which are expressed differentially in different tissues and at different times of development.

you feel at danger,because pinnacle is raising (lol) here, there is smart people that research,just see dans and others.
Your time has passed.

[marcus300]

there is no set rule when it comes to organ growth,in some people it does and in others in doesnt,it all depends on the individual,,,chemicals react in different ways in everybody there is no set rule,,
ive had my organs measured and my heart is enlarged and ive used hgh for many years, but not at a high level of ius a day,,my friend who also uses hgh had his check out and he was fine no large heart or organs,,,its down to the individual

[Robinson]

there is no set rule when it comes to organ growth,in some people it does and in others in doesnt,it all depends on the individual,,,chemicals react in different ways in everybody there is no set rule,,
ive had my organs measured and my heart is enlarged and ive used hgh for many years, but not at a high level of ius a day,,my friend who also uses hgh had his check out and he was fine no large heart or organs,,,its down to the individual

What did the doc say about your heart? Did they say it's a problem? And did you tell him you used hgh?

[marcus300]

What did the doc say about your heart? Did they say it's a problem? And did you tell him you used hgh?

he said my heart was slightly larger than normal,,he said it was because of my steriod use and hgh over the years,,,he said it wasnt at a dangerous size!!

[Pinnacle]

I think that you only hear or read what agrees you (and only you),there is anger in your words,
Get up-to-date !
growth of organsssssss (plural) is from igf1,igf2 and
so on,(or you are in love, only with igf 2?)...............lol.
again.....
the liver does not produce igf 2
nor is transformed from igf 1.
IGF-1 is secreted by the liver
IGF-2 is secreted by the brain, kidney, pancreas and muscle.
The IGF-2 receptor only binds IGF-2 and acts as a "clearance receptor" - it activates no intracellular signalling pathways, functioning only as an IGF-2 sequestering agent and preventing IGF-2 signalling.
IGF-1 and IGF-2 are encoded by two different genes which are expressed differentially in different tissues and at different times of development.

there is smart people that research,just see dans and others.
Your time has passed.

.................

[oswaldosalcedo]

.................

lol...... beautiful grave!


passed pased pased passed

deceased (r)

in verse lol...........