Can you successfully run IGF alone or with AASs? I read that it greatly lowers GH production and so exogenous GH is needed...
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Can you successfully run IGF alone or with AASs? I read that it greatly lowers GH production and so exogenous GH is needed...
no need for hgh while on lr3. i've run it by it self,with aas, with hgh and with both of them and i can honostly say that you will see some nice gains from running it alone if diet is in check(high protein).ofcourse when combined you will def notice some synergie.
-rodge
thanks bro. Have you noticed any gut enlargement due to intestinal growth? I read that the intestines have the most IGF receptors of anything else.Quote:
Originally Posted by rodge nl.
I read a study that said LR3 IGF-1 did not cause negative feedback on the HGH pulse, but as all the studies on LR3 IGF-1 it was done on an animal, so it's only a possibility for humans, not solid proof.
JohnnyB
It's IGF-II that causes the growth and HGH will raise IGF-IIQuote:
Originally Posted by powerliftmike
JohnnyB
dear powerliftmikeQuote:
Originally Posted by powerliftmike
facts for you:
"IGF-1 establishes a negative feedback loop in inhibiting the secretion of growth hormone . This, in turn, reduces the secretion of GHRH (growth hormone releasing hormone ) and stimulates the release of Somatostatin in the hypothalamus. Serum levels of IGF-1 are also modulated by Prolactin , placental lactogen, thyroid hormones and steroids which act, at least in part, by influencing growth hormone levels. IGF-1 is therefore responsible for many, if not all, growth-promoting activities ascribed to Growth hormone . "
gh gut?
------------------------------------
at:
http://www.copewithcytokines.de/cope.cgi?004961
Bro that study is on IGF-1, not LR3 IGF-1 which I'm talking about.Quote:
Originally Posted by oswaldosalcedo
JohnnyB
I want to add, that I did say it was done in animals and wasn't solid eveidence that it wouldn't happen in humans.
JohnnyB
Quote:
Originally Posted by JohnnyB
he asked for igf .....lol......... (just kidding).
relax johnny!
Haha. I guess I meant to say LR3 since it would provide a slow bloodstream release. So no gut growth from IGF-I, just from IGF-II which is enhanced by rhGH administration? Can you buy IGF-II?Quote:
Originally Posted by oswaldosalcedo
i stated that any variant of igf produces belly at:Quote:
Originally Posted by powerliftmike
Roid gut from LR3 IGF1, IGF 1, IGF 2.
http://forums.steroid.com/igf-1-lr3-hgh-insulin-questions/192437-roid-gut-lr3-igf1-igf-1-igf-2-a.html
and
post 19 at:
By using IGF-1 will it make my brain release IGF-2?
http://forums.steroid.com/igf-1-lr3-hgh-insulin-questions/191323-using-igf-1-will-make-my-brain-release-igf-2-a.html
and:
IGF-2 causes small intenstinal growth?
http://forums.steroid.com/igf-1-lr3-hgh-insulin-questions/190948-igf-2-causes-small-intenstinal-growth.html
neither hgh converts in igf1 nor igf 2
and gut growth is from any variant,but no human studies yet.
"BODY GROWTH, CARCASS COMPOSITION, AND ENDOCRINE
CHANGES IN LAMBS CHRONICALLY TREATED WITH
RECOMBINANTLY DERIVED INSULIN-LIKE GROWTH FACTOR-1
YVETTE H. COTTAM, HUGH T. BLAIR, BRIAN W. GALLAHER,
ROGER W. PURCHAS, BERNHARD H. BREIER, STUART N. MCCUTCHEON, AND PETER D. GLUCKMAN
male sheeps were treated for 8 weeks with either 50 mcg/kg body wt/8 hourly SC insulin-like growth factor-I (IGF-I) (n = 10) or with saline (n = 9). IGF-I treatment increased plasma IGF-I from 235 + 17 to 347 + 16 rig/ml (P < 0.001).
suggesting that in the well fed animal with an intact somatotropic
axis IGF-I treatment at doses which double plasma IGFI
does not enhance somatic growth performance. However, the
marked splenomegaly shows the sensitivity of splenic growth to
systemic IGF-I. The suppression of insulin with chronic IGF-I
treatment was accompanied by hyperglycaemia-this may explain
in part the lack of a significant anabolic response and may
limit the utility of IGF-I therapy unless higher doses with
insulin-like effects are used. (Endocrinology 130: 2924-2930)….
…..In conclusion, exogenous IGF-I administered at physiological
doses did not exert marked effects on body wt
gain, carcass dimensions, or body composition in intact,
growing, and well-fed yearling sheep. It had some marked
endocrine and metabolic effects, however, including
suppression of plasma insulin, IGFBP-2, and induced
hyperglycaemia. Marked splenomegaly was also noted.
These changes must be borne in mind in considering any
possible therapeutic use of IGF-I. While IGF-I treatment
in this study did not cause a major somatogenic response
in well fed normally growing animals, higher doses of
IGF-I may be more effective. However, under more severe
conditions such as undernutrition, when GH resistance
occurs (44) IGF-I is a more effective anabolic agonist…..
Organ- control- igf 1 treated
Heart 232.0 +/- 11.0 ------- 230.4 +/ 10.4
Liver 1005.9 +/- 48.5 ----- 1027.0 +/- 45.9
Spleen 78.8 +/- 4.6 ------ 114.6 +/- 4.4 (50 %)
Lungs 502.6 +/- 29.9 ------ 515.1+/- 28.3
Kidneys 131.8 +/- 5.3 ------ 145.6 +/- 5.0"
and:
Am J Physiol Gastrointest Liver Physiol 266: G1090-G1098
Prolonged administration of IGF peptides enhances growth of gastrointestinal tissues in normal rats
C. B. Steeb, J. F. Trahair, F. M. Tomas and L. C. Read
Cooperative Research Center for Tissue Growth and Repair, North Adelaide, South Australia.
To investigate the effect of insulin-like growth factor (IGF) peptide infusion on the gastrointestinal tract, female rats (115 g, 6/group) were treated for 14 days with IGF-I or long R (LR3IGF-I; 0, 44, 111, or 278 micrograms/day) delivered by osmotic minipumps. Both peptides induced a dose-dependent increase in gastrointestinal tissue weight. Total gut weight, small intestinal weight, and small intestinal length increased by 43, 47, and 13%, respectively, after treatment with 278 micrograms/day of LR3IGF-I. Crypt depth and villus height increased after peptide treatment with an associated increased crypt cell population (+33%), cells per villus column (+34%), and villus cell density (+20%). Proportional increments in proliferating cell nuclear antigen labeling and an unaltered crypt growth fraction indicated that the balance between the proliferative and maturation compartment of the crypt was maintained. Fecal nitrogen excretion was significantly reduced in rats treated with LR3IGF-I, suggesting an increased absorptive capacity of the duodenum. The enhanced potency of LR3IGF-I supports previous findings that the gut is especially responsive to analogues with reduced binding affinity to IGF-binding proteins.
and yes you can buy igf2, but is senseless.
see
igf classes:
http://forums.steroid.com/anabolic-steroids-questions-answers/19867-hardgainers-part-2-must-read-skinny-bastard-diet.html
Thanks bro. Has anyone here had problems with gut growth?
I'm using IGF LR3 right now and its helped a lot in my powerlifting stage right now. Squats and deadlifts and be pretty hard on your joints so the extra cushioning is really helping. No roid gut. IGF-II is sometimes called fetal growth factor because its primarily experienced during and after birth. Normally, adults will experience little or no IGF-II and experience only IGF-I. Oh, and yes you can buy IGF-II online... there are a lot of labs that sell growth factors.
Ok, thanks man.Quote:
Originally Posted by Muscle_4_Hire
You're right Bro, that is the problem, people say IGF-1 when they mean LR3 IGF-1, that's where a lot of confusion comes in. So I see your point, he said IGF-1, you post a study on IGF-1. I interpreted it to say LR3 IGF-1 and answered from that interpretation.Quote:
Originally Posted by oswaldosalcedo
I don't know anyone on this board or any others that actually use rhIGF-1 or IGF-1. I've only seen a handful of question on those, but no one has actually used it that I know of
I'm always relaxed, well most of the time :wg:
JohnnyB