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    abcde is offline Female Member
    Join Date
    Sep 2005

    HGH= high blood pressure=coronary probs?

    I just changed to EOD because of HGH water/swelling sides, hoping that EOD will minimize this problem. I also check my blood pressure, so I'm hoping this (potential heart attack) is not a problem. Because I found this at AnabolicMinds, posted byFullyBuilt:

    Why the hell do so many people hold tremendous amount of water while on GH. Especially in doses of 4iu's+ i've noticed its too much water. I've tried cabergoline to reduce prolactin and nolva for estro, but there is another reason why some of us hold so much damn water. Check this article out. Maybe it makes sense. Anyone know whats up. Im thinking the water is potassium related. Maybe there is a way to stop this. Check this article out. Maybe it might make sense.
    Join Date: Nov 2005
    Posts: 16

    I had a discussion on another board about what causes the water retention from HGH and what can be done about it. Doctor Speer thinks that it is caused by ADH and be controlled with Clonidine. "Rager 2500" thinks the water retention is caused by Renin Angiotenisen Aldesterone and can be controlled by using captopril in combination with a mild thiazide.

    Originally Posted by dr. livingstone

    Doctor David Speer thinks the water retention from HGH is caused by an increased release of ADH:

    "The water retension from HGH is due to increased secretion of ADH (anti- diuretic hormone) from the posterior pituitary.
    This hormonal relationship is not in any medical literature. However, it must be true, because the water retension and hypertension are easily controlled by .2mg of clonidine q 12 hours (personal experience). Clonidine's primary action is retarding ADH secretion."

    "Growth hormone , however, causes A.D.H. (Anti-Diuretic Hormone) to go up. ADH is a very potent coronary constrictor which also constricts veins. It is produced starting in the hypothalamus. The nerve endings of certain neurons in the hypothalamus reach into the posterior pituitary, and ADH and oxicitocin come from the posterior pituitary. ADH can go up to 20 times normal levels with fear, or anger, and stress. This can cause coronary constriction within minutes, and this can cause a massive heart attack.
    Growth hormone makes ADH go up, and as a direct effect of this, water retention goes up, which causes higher blood pressure. ADH is dose dependent of GH, which is why you have to drop the dose if blood pressure goes up too high, until your circulatory system adjusts to handle it. This is the only bad side effect of an otherwise very good dose of growth hormone.
    "Clonidine" is the safest high blood pressure medicine. It causes no side effects, and no impotency of any kind. It is indicated if you have high blood pressure due to ADH."

    Rager 2500:

    I found his article as well when I was searching. The thing is, he has no medical research behind it to support his theory. I found 3 articles to support the idea of Renin Angiotenisen Aldesterone is responsible for HGH water bloat. They general idea was to take a blood pressure medication like clonidine, diovan, etc to ensure the blockage of the Angiotensin receptor. The only problem is, blood pressure meds are classified differently such as clonidine and diovan being ARB blockers and captopril being an ACE blocker. Well, it works out that we need the ACE blocker which blocks the Angiotensin Converting Enzyme. Anyways the studies show that you need an ACE blocker with something that blocks the aldesterone pathway like a thiazide dierutic. We had clonidine on hand first, but couldnt figure out why it wasnt working. Thats when we did a further search and found what I posted above. I've tried dostinex (prolactin), clonidine, diovan, and cozzar(all ARB blockers). The only thing that has dried my training partner and I are the captopril with a mild thiazide. I dont try to come off as a HGH guru, just trying to help some bros out here that have been experiencing the problems. Dr. Speer was on the right track, just never did any studies to back it up. Hope this helps Livingstone. I always loved Jins cause of the price and quality, but never wanted to deal with the water bloat.
    Last edited by abcde; 12-11-2005 at 01:00 AM.

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