CJC 1295 and pulsatile GH secretion.

[Cravenmorehead]

This study makes me think we might be overcomplicating matters with multiple peptides.

Pulsatile Secretion of Growth Hormone (GH) Persists
during Continuous Stimulation by CJC-1295, a LongActing GH-Releasing Hormone Analog
Madalina Ionescu and Lawrence A. Frohman
Section of Endocrinology, Metabolism, and Diabetes, University of Illinois at Chicago, Chicago, Illinois 60608
Context: Pulsatile GH secretion is considered important for many of
the hormone’s physiological effects. Short-term GHRH infusions enhance GH pulsatility and increase IGF-I, but the short GHRH half-life
limits its therapeutic use. A synthetic GHRH analog (CJC-1295) that
binds permanently to endogenous albumin after injection (half-life

8 d) stimulates GH and IGF-I secretion in several animal species and
in normal human subjects and enhances growth in rats.
Objective: Our objective was to assess GH pulsatility after a single
injection of CJC-1295 and determine which GH secretion parameters
correlated to the increase in IGF-I production.
Methods: GH pulsatility was assessed by 20-min blood sampling
during an overnight 12-h period in healthy 20- to 40-yr-old men before
and 1 wk after injection of either 60 or 90
g/kg CJC-1295.
Results: GH secretion was increased after CJC-1295 administration
with preserved pulsatility. The frequency and magnitude of GH secretory pulses were unaltered. However, basal (trough) GH levels
were markedly increased (7.5-fold; P  0.0001) and contributed to an
overall increase in GH secretion (mean GH levels, 46%; P  0.01) and
IGF-I levels (45%; P  0.001). No significant differences were observed between the responses to the two drug doses. The IGF-I increases did not correlate with any parameters of GH secretion.
Conclusions: CJC-1295 increased trough and mean GH secretion
and IGF-I production with preserved GH pulsatility. The marked
enhan***ent of trough GH levels by continuous GHRH stimulation
implicates the importance of this effect on increasing IGF-I. Longacting GHRH preparations may have clinical utility in patients with
intact pituitary GH secretory capability. (J Clin Endocrinol Metab
91: 4792– 4797, 2006)

[Cravenmorehead]

j***.endojournals.org/content/91/12/4792.full.pdf+html

[Swifto]

F*ck me.

I was just reading this when you posted it!!!!

[Cravenmorehead]

F*ck me.

I was just reading this when you posted it!!!!

Funny. Looks like we might be able to simplify by just using the CJC1295.......sounds like a once a week injection would do the trick. Would up GH baseline, still maintains pulsatile nature, and raises IGF........BINGO!

[Cravenmorehead]

( I do get tired of having bottles of useless gear when I change my mind.....grrrrrrr)

[Swifto]

Funny. Looks like we might be able to simplify by just using the CJC1295.......sounds like a once a week injection would do the trick. Would up GH baseline, still maintains pulsatile nature, and raises IGF........BINGO!

You any good at converting the dose into mcg?

What dose yielded this?

From my understanding, endogenous GH levels rise steeply for 2-3hours, then decline when using peptides like CJC/GHRP.

I will look at this study again in full tomorrow, I'm tired.

[DanB]

this is cjc with dac is what the study refers to if im reading it correctly which causes gh bleed and this is now thought to be what are trying to avoid and some even have studys showing it to be dangerous, dat has a chart that shows the effects of gh pulses from various peptides including cjc with dac and gh and the chart shows a barely elevated reading when using cjc w dac but 3 healthy spikes from the ghrh/ghrp combo

[Cravenmorehead]

this is cjc with dac is what the study refers to if im reading it correctly which causes gh bleed and this is now thought to be what are trying to avoid and some even have studys showing it to be dangerous, dat has a chart that shows the effects of gh pulses from various peptides including cjc with dac and gh and the chart shows a barely elevated reading when using cjc w dac but 3 healthy spikes from the ghrh/ghrp combo

......this study seems to contradict the gh bleed assertion since the pulses were just as vigorous as without the GHRH. Will have to do more digging. Two patients in a CJC-1295 study did suffer myocardial infarcts which ultimately doomed the marketing of the drug.

[DanB]

yes i remember reading that study but i also read that there could of been other factors that contributed to that, ill try dig it up, have you seen the chart i mentioned? i know it isnt to be taken as gospel but i can see the logic behind it and this is first study ive seen to contraindicate it

[Cravenmorehead]

yes i remember reading that study but i also read that there could of been other factors that contributed to that, ill try dig it up, have you seen the chart i mentioned? i know it isnt to be taken as gospel but i can see the logic behind it and this is first study ive seen to contraindicate it

Yeah.....it shows a baseline GH level elevated with no pulsatile action I believe......can't remember where I saw it. I do know I'm starting to retain water so I'm backing off the peptides. Normally I'm dry as a bone. When the veins on the front of the lower leg aren't popping......I know it's time to re-examine the goodies.

[DanB]

pm sent . . . . . . . .

[Cravenmorehead]

CJC GHpulse around 10ng/ml......mod and -2 GH pulse around 100ng/ml......10x......is that good or bad?

[DanB]

i dont really know i guess we will find out in years to come lol

[Razor]

If once a week would work, this is great new for my gf. I just started giving her peptides to help heal some old injuries.
She hates needles so this is idea for her.

What does this mean Swifto? "A synthetic GHRH analog (CJC-1295) that
binds permanently to endogenous albumin after injection ?