01-17-2004, 07:47 PM #1Senior Member
- Join Date
- May 2002
Long R3 IGF-1....better than GH? very interesting
Long R3 IGF-1
My friend is working with this right now in a supposed research capacity I assume... A buddy that just used in a cycle sent me this article. My friends all have proclaimed this as the drug to surpass GH... I have two friends that have used this and for starters it is not something everyone will have access to an will not be greatly attainable in any near future... (FDA sucks cock…. F%ck Little b!tches) sorry for that…
The only fear is the unknown.... I believe IGF-1 long R3 with heavy doses of AAS, insulin and growth is the danger... but alone or with moderate doses of AAS would be the safer health conscience method.
I must say one of the two friends is not exactly health conscience and already has an enlarged heart but the other a more moderate user of designer BBing drugs is much more health conscience... I am currently trying to milk information as to their health and well being while using IGF-1 Long R3
IGF-1 Long R3
1. IGF stands for insulin-like growth factor. It is a
natural substance that is produced in the human body
and is at its highest natural levels during puberty.
During puberty IGF is the most responsible for the
natural muscle growth that occurs during these few
years. There are many different things that IGF does
in the human body; I will only mention the points that
would be important for physical enhancement. Among the
effects the most positive are increased amino acid
transport to cells, increased glucose transport,
increased protein synthesis, decreased protein
degradation, and increased RNA synthesis.
When IGF is active it behaves differently in different
types of tissues. In muscle cells proteins and
associated cell components are stimulated. Protein
synthesis is increased along with amino acid
absorption. As a source of energy, IGF mobilizes fat
for use as energy in adipose tissue. In lean tissue,
IGF prevents insulin from transporting glucose across
cell membranes. As a result the cells have to switch
to burning off fat as a source of energy.
IGF also mimic's insulin in the human body. It makes
muscles more sensitive to insulin's effects, so if you
are a person that currently uses insulin you can lower
your dosage by a decent margin to achieve the same
effects, and as mentioned IGF will keep the insulin
from making you fat.
Perhaps the most interesting and potent effect IGF has
on the human body is its ability to cause hyperplasia,
which is an actual splitting of cells. Hypertrophy is
what occurs during weight training and steroid use , it
is simply an increase in the size of muscle cells.
See, after puberty you have a set number of muscle
cells, and all you are able to do is increase the size
of these muscle cells, you don't actually gain more.
But, with IGF use you are able to cause this
hyperplasia which actually increases the number of
muscle cells present in the tissue, and through weight
training and steroid usage you are able to mature
these new cells, in other words make them grow and
become stronger. So in a way IGF can actually change
your genetic capabilities in terms of muscle tissue
and cell count. IGF proliferates and differentiates
the number of types of cells present. At a genetic
level it has the potential to alter an individuals
capacity to build superior muscle density and size.
There is a lot of talk about the similarity between
IGF and growth hormone . The most often asked question
is simply which is more effective. GH doesn't directly
cause your muscles to grow, it works very indirectly
by increasing protein synthesis capabilities,
increasing the amount of insulin a person can use
effectively, and increasing the amount of anabolic
steroids a person can use effectively. GH also
indirectly causes muscle growth by stimulating the
release of IGF when it (the GH) is destroyed in the
human body. So one way you could look at it as GH
being a precursor to IGF. So to put it simple IGF is
more effective at directly causing muscle growth and
density increases. IGF is also much more cost
IGF can also be effectively used by itself and gains
will still be easily noticeable. With growth hormone
you need to use high amounts of anabolics and often
insulin to see any gains at all, this is not the case
with IGF. IGF can be used by itself and is often used
by bodybuilders who bridge between cycles, during this
bridge is a good time to use IGF since it has no
effect on natural testosterone production so it will
therefore allow you to return to normal in terms of
hormone levels. A stack of IGF, PGF2a, HCG , and clomid
would be a good bridge stack and would allow your body
to return to normal and still allow you to retain and
make new gains.
IGF is a research drug, it hasn't been approved by the
FDA for use as a pharmaceutical and it is currently
being researched for nerve tissue repair, possible
burn victims, and also as a possible aid in muscle
wasting for AIDS patients. There are many different
analogs of IGF available, instead of mentioning them
all, I will simply mention the two most common and the
most effective. Regular recombinant IGF is one of the
two, it is also the more expensive and the least
effective. Regular IGF only has a half-life of about
10-20 minutes in the human body and is quickly
destroyed, it can be combined with certain binding
proteins to extend the half-life, but it is not a very
simple procedure and there is a more effective and
less expensive version available. The most effective
form of IGF is Long R3 IGF-1, it has been chemically
altered and has had amino acid changes which cause it
to avoid binding to proteins in the human body and
allow it to have a much longer half life, around 20-30
hours. "Long R3 IGF-1 is an 83 amino acid analog of
IGF-1 comprising the complete human IGF-1 sequence
with the substition of an Arg(R) for the Glu(E) at
position three, hence R3, and a 13 amino acid
extension peptide at the N terminus. This analog of
IGF-1 has been produced with the purpose of increasing
the biological activity of the IGF peptide."
"Long R3 IGF-1 is signifacantly more potent than
IGF-1. The enhanced potency is due to the decreased
binding of Long R3 IGF-1 to all known IGF binding
proteins. These binding proteins normally inhibit the biological actions of IGF's."
It is also not as expensive since a media grade
version is available which is sufficient for
bodybuilding use. There is also a receptor grade
available but it is VERY expensive and the only
noticeable difference between the two would only be
able to be noticed in a laboratory setting. The price
on the black market for Long R3 IGF-1 can be seen
anywhere from $300-$500 per milligram depending on the
source, be wary of black market dealers of any IGF
since it is a VERY difficult item to obtain. As
mentioned IGF is a research product and is only
available from a few laboratories in the world and is
only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.
Any form of IGF is ONLY supplied in a lyphosized form,
which means a dry powder state. NEVER PUCHASE
PRE-DILUTED LIQUID IGF!!!! There is no such product
made anywhere in the world and even if there were real
IGF ever present in the vial it would all be dead by
the time you receive it. IGF is a very delicate
peptide and must be diluted by yourself, where you
have access to a refrigerator and freezer. There has
also been a lot of talk by certain sources claiming to
have IGF made by the Eli Lilly company, to clear
things up Lilly is a pharmaceutical company and as
stated IGF is a research drug and has not yet been
approved, Lilly does not and never has manufactured
research drugs for retail sale.
The dilutents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer(sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the dilutents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary dilutents.
The most effective length for a cycle of IGF is 50
days on and 20-40 days off. The most controversy
surrounding Long R3 IGF-1 is the effective dosage. The
most used dosages range between 20mcg/day to
120+mcg/day. IGF is only available by the milligram,
one mg will give you a 50 day cycle at 20mcg/day, 2mg
will give you a 50 day cycle at 40mcg/day, 3mg will
give you a 50 day cycle at 60mcg/day, 4mg will give
you a 50 day cycle at 80mcg/day and so on. The dosage
issue mainly revolves around how much money you have
to spend, plenty of people use the minimum dosage of
20mcg/day and are happy with the results, and in fact
several top bodybuilders use the 20mcg/day dosage and
are pleased with the results. IGF is most effective
when administered subcutaneously and injected once or
twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training.
Another frequently asked question of IGF refers to the
real world results, in terms of pure weight gain don't
expect to gain 5 lbs. a week like you may off of
anadrol or a similar steroid. The only weight you will
gain from IGF use is pure lean muscle tissue, with
steroids most of the weight gained is water weight.
With an effective dosage you can expect to gain 1-2
lbs of new lean muscle tissue every 2-3 weeks and
these effects can be increased with the use of
testosterone, anabolic steroids , and insulin use.
Increased vascularity is also very common, people
report seeing veins appear where they never have
before. And yet another effect reported is the ability
to stay lean while bulking with heavy dosages of
steroids and TONS of food while on an IGF cycle, this
is perhaps the most pleasing effect. Increased pumps
are also noticeable almost immediately, the pumps can
almost become painful, pumps are even noticeable when
Overall, IGF is a very exciting drug due to its
ability to alter ones genetic capabilities. If you can
find a trustworthy source and you use it correctly it
can be a VERY useful tool in your bodybuilding drug arsenal.
01-17-2004, 08:20 PM #2
good read.....bayou mike you read this?
01-17-2004, 08:54 PM #3
on the MC board there is a whole forum dedicated to IGF-1, with most of it referring to IGF-1 LR3. I can't post a link to that forum, but if you don't know what MC is, you can pm me. It's hard to compare GH and IGF-1, since most of the welcomed effects of GH are from GH stimulating increased IGF-1 production. Dollar for dollar, IGF-1 LR3 is the way to go. As far as prices, those above are way high. If you pay more than $200/mg, you're getting screwed. There are a few companies that I know of that sell 3mg for $550.
01-17-2004, 10:39 PM #4
I finished my first cycle of IGF a few weeks ago. Definetly can feel a change when I was on it and off.
01-18-2004, 07:16 PM #5
Same here..loved it
05-29-2004, 03:00 PM #6
Now since I've never done IGF and Insuline there's one thing I don't understand...
Your article says the most effective duration of a cycle is 50 days on and
20-40 days off
(while most people on this board advocate a 20-30 day cycle, but that may well be cost-related --> I personally with any cycle always do MINIMUM of Time "on" is Time "off" so 50 days on would mean a minimum of 50 days off!)
But since IGF-L3 is most effective when used in conjunction with Insuline (so to longer its effects due to otherwise BP3 binding to it and other "nasty processes") wouldn't 50 days of consecutive use of Insuline be a bit risky for a healthy person (so a non-diabetic)?
Also I want to know; I always train 4-5 days a week, so if I use IGF-L3 and Insuline I should also take it on my "non training days" but when would be the best time of day for that then?
And what would be more effective?
Shooting twice a day (and at what subjective times --> e.g. first thing in the morning, post-workout, before bed, with meals... You get the point!)
Shooting once (probably post-workout)...
Thanks for the input on these questions
05-29-2004, 03:23 PM #7Originally Posted by kingofmasters
Resistance training causes upregulation of IGF receptors in the muscles worked, so shooting post workout into the muscles just worked creates, statistically/kinetically, the best opportunity for effects in that/those muscles. it's not clear for how long IGF receptors are upregulated, so shootin gin the AM on an off day into the muscles worked the previous workout is what I do. Alternatively, you could JUST shoot the combo ob workout days. LR3 is also going to cause feedback inhibition and suppress endogenous GH release, so 2x/day administration provides nearly a 24 hour suppressive effect on GH release.
The article above is also a bit dated.
05-29-2004, 03:39 PM #8Originally Posted by einstein1905
But just to summarize (what you say) best is:
1) Once a day Post Work-out (better then injecting twice a day)
2) On "off" days shooting First thing in the Morning
3) Optional: Only shooting on Work-out days
Did I understand it right?
If so, what is your theory on Option 3
--> Wouldn't a consecutive adminstration of IGF
every day during entire IGF-cycle
be much more effective than this "on"/"off" aproach?
(so shooting on work-out days and not shooting on weekends for instance)
Last edited by kingofmasters; 05-29-2004 at 03:41 PM.
05-29-2004, 04:14 PM #9
Shooting ED is what I do. the only good reason to just inject on workout days would be financial reasons IMO.
Originally Posted by kingofmasters
06-24-2004, 09:49 PM #10Junior Member
- Join Date
- May 2004
How do you do a 20mcg injection? Isn't that microscopic?
06-25-2004, 10:40 AM #11
use a slin pin bro
06-25-2004, 09:29 PM #12
****...I'm really interested in this stuff now!
07-04-2004, 09:40 PM #13
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