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Thread: Formestane

  1. #1
    Lozgod's Avatar
    Lozgod is offline Anabolic Member
    Join Date
    Mar 2003
    Philly - Better than you


    I just read an article in MD that this is supposed to be the ultimate Anti_E/PCT drug out there. It increases IGF, inhibits amoratizing, raises natural test levels, also protects from progesterone related sides. However it needs to be made in to an injectable to be effective. Anyone know any recipes. I posted a thread in the lab also.

  2. #2
    ENraged's Avatar
    ENraged is offline Senior Member
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    Aug 2003
    im not sure about haveing to be injectable to work
    everything i have researched has not said that directly:

    Formestane (4-hydroxyandrostenedione) is an aromatase inhibitor which significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer. Objective response rates in heavily pretreated patients with advanced breast cancer generally range between 20 and 30% during treatment with intramuscular formestone 250 or 500mg once every 2 weeks, and a further 20 to 30% of patients experience disease stabilisation. The median duration of response is between 8 and 14 months. Highest response rates are observed in soft tissue metastases, in patients with estrogen-responsive tumours and in those showing a response to previous endocrine therapy. Furthermore, there is some evidence to suggest that higher response rates are achieved with formestane 500 versus 250mg once every 2 weeks. In comparative studies, the clinical efficacy of intramuscular formestane 250mg did not differ significantly from that of oral megestrol when administered as second-line endocrine therapy to patients with advanced disease in whom previous tamoxifen therapy had failed. In addition, formestane produced a response rate, duration of response and overall survival rate that was not significantly different from that of oral tamoxifen when administered as first-line endocrine therapy to patients with advanced disease, but tamoxifen was superior in some measures. Further investigation of these 2 agents, including the higher dosage of formestane (500mg), is necessary to confirm their relative efficacies. Formestane is well tolerated by the majority of patients; adverse events rarely necessitate cessation of therapy. The most common adverse events are local reactions at the injection site and systemic events usually related to the effect of the drug on the hormonal milieu. The systemic tolerability of formestane is similar to that of tamoxifen but better than that of megestrol. Thus, formestane is effective and well tolerated as first-line endocrine therapy for advanced disease. However, at present, it is unlikely to challenge tamoxifen in this indication, based on recent findings from a large comparative study and the fact that formestane requires intramuscular administration. Nonetheless, formestane, which appears to have a better tolerability profile than other currently available second-line agents (including megestrol and the aromatase inhibitor aminoglutethimide), is a valuable drug for the second-line treatment of postmenopausal women with advanced breast cancer.

  3. #3
    NewBreed is offline Associate Member
    Join Date
    Mar 2004
    How about rhe Forrmestane from H.M.Gear?
    It sounds very promising and compared to Arimidex a real alternative.
    Has anyone tried it already?
    I´m courious about it compared to Ari,Clomis and Nolva and the price seems to be OK.-H.M.Gear claims that their gear is safe for injection.


  4. #4
    dumblucky's Avatar
    dumblucky is offline Member
    Join Date
    Nov 2001
    sin city
    If the stuff actually works the way that the article states then it will be the bestway to go and yes you must inject it but it states the half life is four days so every 4 days woudl be awesome
    right now HM gear is the only one selling it as a liquid form
    the instuction say its for oral use but the only way they can sell it is to say its oral not IM use
    same thing with synthol
    Yea the price isnt bad but its a lot more expensive than any of the anti e stuff I can get right now
    (of course my powder source is amazing in price)
    if I was paying full black market prices that I have seen for actuall clomid tabs and nolva tabs
    i would prolly go with Forrmestane from H.M.Gear

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