Anabolics
Search More Than 6,000,000 Posts
Results 1 to 5 of 5

Thread: tamoxifen

  1. #1
    billyg68 is offline Junior Member
    Join Date
    Nov 2002
    Posts
    68

    tamoxifen

    Is tamoxifen a safe buy? I'm being offered 30 tabs. They have Barr written in one side and 446 on the other.

    Thanks.

  2. #2
    Big "D" Daddy's Avatar
    Big "D" Daddy is offline Junior Member
    Join Date
    May 2002
    Location
    Daytona Beach
    Posts
    127
    Tamoxifen Citrate is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, tamoxifen appears to exert its antitumor effects by binding the estrogen receptors.

    In cytosols derived from human breast adenocarcinomas, tamoxifen competes with estradiol for estrogen receptor protein.

    Tamoxifen is extensively metabolized after oral administration. Studies in women receiving 20 mg of 14C tamoxifen have shown that approximately 65% of the administered dose is excreted from the body over a period of 2 weeks with fecal excretion the primary route of elimination. The drug is excreted mainly as polar conjugates, with unchanged drug and unconjugated metabolites accounting for less than 30% of the total fecal radioactivity.

    N-desmethyl tamoxifen is the major metabolite found in patients' plasma. The biological activity of N-desmethyl tamoxifen appears to be similar to that of tamoxifen. 4-Hydroxytamoxifen and a side chain primary alcohol derivative of tamoxifen have been identified as minor metabolites in plasma.

    Following a single oral dose of 20 mg tamoxifen, an average peak plasma concentration of 40 ng/mL (range 35 to 45 ng/mL) occurred approximately 5 hours after dosing. The decline in plasma concentrations of tamoxifen is biphasic with a terminal elimination half-life of about 5 to 7 days. The average peak plasma concentration of N-desmethyl tamoxifen is 15 ng/mL (range 10 to 20 ng/mL). Chronic administration of 10 mg tamoxifen given twice daily for 3 months to patients results in average steady-state plasma concentrations of 120 ng/mL (range 67-183 ng/mL) for tamoxifen and 336 ng/mL (range 148-654 ng/mL) for N-desmethyl tamoxifen. The average steady-state plasma concentrations of tamoxifen and N-desmethyl tamoxifen after administration of 20 mg tamoxifen once daily for 3 months are 122 ng/mL (range 71-183 ng/mL) and 353 ng/mL (range 152-706 ng/mL), respectively. After initiation of therapy, steady state concentrations for tamoxifen are achieved in about 4 weeks and steady state concentrations for N-desmethyl tamoxifen are achieved in about 8 weeks, suggesting a half-life of approximately 14 days for this metabolite.

    In a 3-month crossover steady-state bioavailability study with Tamoxifen Citrate 10 mg twice a day vs. Tamoxifen Citrate 20 mg given once daily, Tamoxifen Citrate 20 mg taken once daily had similar bioavailability to Tamoxifen Citrate 10 mg taken twice a day.

  3. #3
    desert rat is offline Junior Member
    Join Date
    Aug 2002
    Location
    Arizona
    Posts
    52
    If you're asking about whether its fake or not I don't think there's any fakes. What you have is the generic form of Nolvadex .

  4. #4
    desert rat is offline Junior Member
    Join Date
    Aug 2002
    Location
    Arizona
    Posts
    52
    By the way what mg tabs are they? One should always have Nolva on hand for any cycle so if you don't have many options I would grab it while you can

  5. #5
    billyg68 is offline Junior Member
    Join Date
    Nov 2002
    Posts
    68
    Thanks for replying, D. They are 10mg. I'm planning on doing my first cycle around the middle of January and I'm trying to gather as much Nolvadex as I can. I grabbed some clomid too.

    Thanks

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •