Originally Posted by BigJames
The difference between concentrate and isolate is in how it is filtered. Whey concentrate is filtered a couple of times to remove as much lactose and fat as possible through filtration, then it is kiln dried to a powder form. The pros: it is cheaper, it takes longer to digest so it stays in your system longer. The cons: as it is kiln dried ,the protein can become "burned" and there is a school of thought that it loses some of its bio-availablility. Whey Isolate is filtered the same as concentrate and then it is run through a ionization filter that uses a technical process (I cannot remember the name) to pull the fat and lactose molecules out of the mix leaving only pure protein isolate powder behind. Pros: it absorbs faster and some argue, more completely, it mixes better without clumping.
I use concentrate due to cost, but I have heard several arguements that the slower digestion of concentrate may actually have benefits. If I could, I would use a concentrate for most of my shakes in a day and save the isolate for post-workout shake due to the faster absorbtion.